Ganglion News and Research

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In anatomy, a ganglion (plural ''ganglia'') is a biological tissue mass, most commonly a mass of nerve cell bodies. Cells found in a ganglion are called ganglion cells, though this term is also sometimes used to refer specifically to retinal ganglion cells.

Gene therapy and special goggles help some blind adults detect objects again

In a phase 1 study of 10 adults with advanced retinitis pigmentosa, researchers found that optogenetic gene therapy combined with light-stimulating goggles was generally well tolerated, although one participant experienced a severe but transient ocular adverse event. Seven participants showed improved light sensitivity, while four of eight who completed behavioral testing demonstrated modest gains in visual function, providing preliminary evidence of partial vision restoration that requires confirmation in larger controlled trials.

12 Oct 2026

Optogenetic therapy improves light sensitivity in people with retinitis pigmentosa

An international research team has reported new results from the first clinical cohort of blind people treated with an optogenetic therapy for advanced retinitis pigmentosa.

7 Oct 2026

Novel peptide approach reduces chronic neuropathic pain in mice

Understanding and treating chronic neuropathic pain has remained challenging due to its complex nature. New research from the lab of Clifford Woolf, MB, BCh, PhD, at Boston Children's Hospital's FM Kirby Neurobiology Center describes a novel approach for reducing pain by disrupting interactions within pain-sensing nerve cells called nociceptors

6 Oct 2026

Specialized immune cells bridge the nervous and immune systems

A collaborative team led by Professor Jie Zhou at Tianjin Medical University School of Basic Medicine and Professor Qiang Liu at Tianjin Medical University General Hospital published a comprehensive review in Volume 2 of the journal Immunity & Inflammation on September 8, 2026.

25 Sep 2026

Targeted antibody therapy provides long-lasting relief from neuropathic pain

Pain is a natural protective mechanism that alerts the body to actual or potential injury. But when nerves themselves are damaged, they can generate abnormal pain signals even in the absence of a new injury.

16 Sep 2026

Eye scans detect signs of atrial fibrillation years before diagnosis

People with atrial fibrillation have signs of the condition in the retinas of their eyes that can be detected as early as four years before diagnosis, finds a new study led by University College London (UCL) and Moorfields researchers.

14 Sep 2026

Psilocybin protects sensory nerves from chemotherapy damage in preclinical study

In mouse models, prophylactic psilocybin prevented or reduced multiple features of chemotherapy-induced peripheral neuropathy, with cycle-matched dosing sustaining protection during repeated cisplatin exposure without measurably affecting tumor growth. Experiments in human-derived sensory neurons and ex vivo peripheral nerves linked the effect to 5-HT2A-dependent preservation of mitochondrial trafficking and local axonal energy supply, while a nonhallucinogenic 5-HT2A agonist reproduced protection against mechanical hypersensitivity.

6 Sep 2026

Stanford scientists develop an ultracompact gene activation tool

The ability to precisely adjust the expression of genes inside the human body - ramping up protective ones and tamping down harmful ones - holds enormous potential for treating and preventing disease.

28 Aug 2026

New eye imaging technology captures clearer details of retina

Modern OCT devices can look inside the eye without a scalpel - but they do not always capture everything that matters. Some critical information is simply lost, blurred by scattered photons.

24 Jun 2026

Scientists reveal how cGAS-STING fuels brain inflammation and neurodegeneration

The cGAS-STING pathway is emerging as a key driver of chronic neuroinflammation through its effects on glial activation, neuronal stress, blood-brain barrier integrity, and type I interferon signaling. The review highlights why selective, context-dependent modulation of cGAS-STING could help treat neurodegenerative diseases, while preserving its essential roles in antiviral defense and tumor surveillance.

10 Jun 2026

New AI framework maps systemic obesity damage at cellular resolution

Researchers at Helmholtz Munich, the Ludwig Maximilians University Munich (LMU) and collaborating institutions have developed an artificial intelligence (AI) framework that maps disease-related changes throughout the entire mouse body at cellular resolution.

20 May 2026

Dual approach strengthens recovery for military PTSD

Military service members and veterans frequently experience post-traumatic stress disorder (PTSD), which is linked to a range of psychological challenges and adverse effects.

17 Feb 2026

Engineered vessels boost retinal organoid function, enabling advanced disease modeling

Until now, it has been difficult to maintain retinal ganglion cells deep inside organoids over extended periods. The supply of nutrients and oxygen in the densely packed tissues is limited, leading to cell death.

14 Jan 2026

$Neural pain pathways found to play crucial role in bone fracture healing$

Neural pain pathways found to play crucial role in bone fracture healing

When a house catches on fire, we assume that a smoke alarm inside will serve one purpose and one purpose only: warn the occupants of danger.

8 Jan 2026

Skin and internal organs sense cold through different molecular pathways

A research team led by Félix Viana, co-director of the Sensory Transduction and Nociception laboratory at the Institute for Neurosciences (IN), a joint research centre of the Spanish National Research Council (CSIC) and Miguel Hernández University of Elche (UMH), has demonstrated that the body uses different molecular mechanisms to detect cold in the skin and in internal organs.

19 Dec 2025

Everyday light exposure shapes how alert and mentally sharp we feel outside the lab

This real-world study shows that recent and habitual light exposure are linked to lower subjective sleepiness and faster reaction times in daily life. Brighter and more stable daytime light patterns were associated with better performance on specific cognitive tasks, independent of sleep and time of day.

18 Dec 2025

TRPM1 loss drives rhythmic activity across retinal diseases

Rhythmic electrical activity in the retina (known as pathological oscillations) has been observed in several eye diseases, including congenital stationary night blindness (CSNB) and retinitis pigmentosa (RP).

18 Nov 2025

Two analgesic drugs may one day be repurposed as anti-tumor therapies

Peripheral afferent neurons - nerves that send signals from all areas of the body to the central nervous system (brain and spinal cord) - are known to infiltrate and grow within malignant bone tumors called osteosarcomas, often accompanied by severe pain.

29 Oct 2025

The real resolution limit of the human eye

Findings on human visual resolution reveal that eyes reach detail limits before 8K displays, impacting future display and video coding technologies.

29 Oct 2025

Advancements in organoids could transform treatment of spinal cord injury and peripheral nerve injury

A recent review published in Engineering explores the construction and potential applications of spinal cord and peripheral nerve organoids for regenerative medicine in neurotrauma.

24 Oct 2025