Hyperalgesia News and Research

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NIH’s continued investment fuels TMJ pain research

Chronic pain is one of the most common health conditions worldwide. Back pain is the most frequently reported type, followed closely by head and face pain linked to the jaw joint, in the form of temporomandibular joint (TMJ) disorder.

27 Feb 2026

Sound stress alone induces pain sensitivity and brain inflammation

Pain is an important physiological response in living organisms. While physical pain is an outcome of tissue damage, pain can manifest as diverse unpleasant sensory and emotional experiences. Many studies report that emotional or psychological stress enhances pain responses.

18 Jul 2025

New approach to treating chronic pain without opioids

Chronic pain, a common and debilitating condition, often leads practitioners to prescribe opioids in escalating doses.

22 Apr 2025

Innovative blood testing tech could spell the end of needle phobia

UK-based blood testing company Thriva has joined forces with medical device manufacturer Tasso to use their innovative blood testing technology to tackle needle phobia, a condition that affects at least 1 in 10 adults.

11 Apr 2025

Opioid δ-receptor agonists show promise for treating IBS-like symptoms

Research reveals that δ-receptor agonists like KNT-127 alleviate IBS symptoms by modulating gut-brain interactions and reducing stress-induced hypermotility.

7 Feb 2025

Annona squamosa extracts show promise in treating pain and arthritis

In Brazil, researchers have identified substances with analgesic, anti-inflammatory, anti-hyperalgesic (against persistent pain) and anti-arthritic activity in the leaves of Annona squamosa, a tree popularly known in the country as fruta-do-conde or pinha.

20 Dec 2024

Low-dose ketamine may be an effective adjunct analgesic to morphine for managing acute pain

A new study that investigates low-dose ketamine (LDK) as an adjunct to morphine for treating acute pain has been published in the October issue of Academic Emergency Medicine (AEM), the peer-reviewed journal of the Society for Academic Emergency Medicine (SAEM).

19 Nov 2024

Non-viral gene therapy offers hope for chronic low back pain sufferers

A novel non-viral gene therapy for discogenic back pain (DBP).

20 May 2024

Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems - prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia.

9 Apr 2024

Study unravels molecular basis of chronic pain transition

Researchers from the Center for Translational Immunology at University Medical Center Utrecht (the Netherlands) have identified that a transient inflammatory pain causes mitochondrial and redox changes in sensory neurons that persist beyond pain resolution.

8 Nov 2023

Repeated emotional stress in mice provokes irritable bowel syndrome-like symptoms

The evidence for the interconnection between emotional states and intestinal conditions has grown recently. These findings have led researchers to speculate about the association between the brain and the gut – the "gut-brain axis."

9 Nov 2022

Gut bacterial 'super-producer' of histamine can cause pain flare-ups in some IBS patients

Researchers from McMaster University and Queen's University have discovered a gut bacterial 'super-producer' of histamine that can cause pain flare-ups in some patients with irritable bowel syndrome (IBS).

27 Jul 2022

Researchers receive $1.1 million to study the safety, efficacy of drug combination for chronic pancreatitis

Researchers from Indiana University School of Medicine are studying the safety and efficacy of a drug combination for patients with chronic pancreatitis (CP).

2 Jun 2022

New stimulation method provides effective and personalized pain relief without side effects

Researchers at Lund University in Sweden have developed a completely new stimulation method, using ultra-thin microelectrodes, to combat severe pain.

13 Oct 2021

Finding ways to relieve painful intercourse

Researchers at Flinders University are working to remedy this situation by identifying what triggers this chronic pain in the female reproductive tract.

4 Feb 2021

Regular cannabis use does not appear to increase pain sensitivity, study suggests

A recent study examining pain among cannabis users suggests that--unlike long-term opioid use--regular cannabis use does not appear to increase pain sensitivity.

10 Sep 2020

Back-pain patients taking opioid painkillers produce anti-opioid antibodies

University of Wisconsin-Madison scientists have discovered that a majority of back-pain patients they tested who were taking opioid painkillers produced anti-opioid antibodies.

17 Aug 2020

Scientists identify a novel method for treating chronic pain

Watching immersive 360 videos of icy Arctic scenes helps to relieve intense burning pain and could hold hope for treating chronic pain, a small study has found.

8 Nov 2019

Gulf War Illness and chronic fatigue syndrome are two very distinct diseases of the brain

Gulf War Illness (GWI) and chronic fatigue syndrome (CFS) share symptoms of disabling fatigue, pain, systemic hyperalgesia (tenderness), negative emotion, sleep and cognitive dysfunction that are made worse after mild exertion (postexertional malaise).

23 Oct 2019

Study may help scientists to learn more about the causes of chronic pain

Researchers from North Carolina State University have found that inflammation increases neuronal activity, gene expression and sensory nerve (neurite) outgrowth in neurons involved in thermal - but not physical- sensations in mice.

27 Sep 2019