Immunohistochemistry News and Research

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Immunohistochemistry (IHC) is an imaging technique to visualize antigens in cells. Labeled antibodies bind to target antigens in the cell to image the distribution and localization of specific proteins of interest

AtlasPlex™ brings custom 5-plex IHC on FFPE tissue into a single day

Atlas Antibodies has launched AtlasPlex™, a new ready-to-use multiplex immunohistochemistry kit. It lets researchers build their own 3- or 5-plex panels from more than 17,000 IHC-validated antibodies covering over 12,000 human genes.

From Atlas Antibodies AB 30 Sep 2026

Early-life stress rewires brain epigenetics to heighten sensitivity to future stress

. Early-life stress increased SETD7 and H3K4me1 in the ventral tegmental area of mice, creating an epigenetically primed state that heightened later transcriptional, neuronal, and behavioral responses to stress. Reducing Setd7 during development lowered H3K4me1 and weakened these stress-sensitizing effects, identifying a mechanism that may help explain how early adversity leaves lasting biological effects.

11 Aug 2026

A closer look at Parkinson’s brains finds tau where standard tests saw little

Researchers used single-molecule and super-resolution imaging to profile protein aggregates across six brain regions from 29 post-mortem donors, detecting high-intensity phosphorylated tau aggregates in the Parkinson’s disease putamen despite negligible conventional tau staining. PD cases with dementia showed greater tau burden than those without dementia, while the assay did not detect a PD-specific population of nanoscopic alpha-synuclein aggregates.

29 Jul 2026

Case study shows how accurate diagnosis can guide personalized treatment for renal oncocytoma

A new case report was published in Volume 17 of Oncotarget on July 2, 2026, titled "Renal oncocytoma: Α case report and literature review."

6 Jul 2026

New AI framework outperforms conventional biomarkers in predicting cancer survival

Digestive system cancers, including hepatobiliary and gastrointestinal malignancies, remain a major global oncological burden. Although immune checkpoint inhibitors have changed the treatment landscape for some patients, their overall efficacy remains limited, with only about 15% to 30% of patients achieving durable clinical benefit.

1 Jul 2026

Scientists uncover immune mechanisms driving rare gastrointestinal disorder

A collaborative team led by Dr. Jingnan Li and Dr. Ji Li at Peking Union Medical College Hospital, together with Associate Professor Xiaohuan Guo at Tsinghua University and Academician Ye-Guang Chen at Tsinghua University School of Life Sciences, published a study in Volume 2, article number 28 of the journal Immunity & Inflammation on June 17, 2026.

26 Jun 2026

Skin barrier monitoring predicts necrosis after skin flap surgery

Random-pattern skin flaps (RPSFs) receive blood mainly from small subcutaneous vessels rather than a defined axial vessel, leaving them vulnerable to ischemia and hypoxia after surgery.

23 Jun 2026

Researchers advocate local data strategies for early cancer detection

Researchers are calling for the application of locally driven strategies, supported by stronger regional evidence, to improve early cancer detection and precise care.

22 Jun 2026

Stretchable wound zipper controlled by smartphone app accelerates skin healing

Skin is our protective barrier from the outside world, and it is highly susceptible to damage. To prevent infection, restore protective skin cells, and reduce scarring, it is essential to quickly and robustly close a wound.

11 Jun 2026

New findings highlight risks and therapeutic targets in systemic sclerosis

Systemic sclerosis is a rare connective tissue disorder characterised by autoimmune features with vascular manifestations, causing fibrosis of the skin and internal organs.

7 Jun 2026

Biopsy-driven treatment strategy improves clinical outcomes in psoriatic arthritis

The management of psoriatic arthritis is increasingly focused on the early identification of clinical, immunological, and tissue-based phenotypes predictive of therapeutic response.

5 Jun 2026

Case report highlights diagnostic features of rare eyelid sebaceous adenoma

A new case report was published in Volume 13 of Oncoscience on April 2, 2026, titled "Sebaceous adenoma of the eyelid: A clinical, histopathological, and immunohistochemical perspective."

4 Jun 2026

Three-drug strategy forces pancreatic tumors into lasting regression

A triple-targeted preclinical therapy combining daraxonrasib, afatinib, and SD36 drove durable pancreatic cancer regression by blocking KRAS/RAS, EGFR/HER2, and STAT3 signaling. The approach prevented treatment resistance across mouse and human tumor-derived models, but remains preclinical and requires more clinically suitable drug combinations before human testing.

2 Jun 2026

Novel theranostic approach targets aggressive neuroendocrine prostate cancer

A novel theranostic approach that targets RET -- a newly identified biomarker for neuroendocrine prostate cancer enables high-contrast PET imaging and effective, safe treatment for this highly aggressive malignancy.

2 Jun 2026

New PET tracer offers a powerful tool for kidney cancer staging

A new PET tracer targeting carbonic anhydrase IX (CAIX) has demonstrated exceptional sensitivity and high tumor-to-background contrast in detecting clear cell renal cell carcinoma (ccRCC), according to early clinical research.

1 Jun 2026

How a tiny H5N1 dose triggers massive virus shedding in cow milk

Experimental infection studies in lactating Holstein cows showed that H5N1 B3.13 can infect the bovine mammary gland at doses as low as 10 TCID50, producing extremely high viral loads in milk. However, the virus did not transmit to sentinel cows through repeated exposure to contaminated milking equipment or through close contact under high-biocontainment conditions, suggesting that real-world dairy-farm spread depends on additional cofactors.

25 May 2026

New FUSILLI tool improves gene fusion detection in pediatric leukemia

Researchers have introduced a novel diagnostics method that can more sensitively detect gene fusions in B-cell acute lymphoblastic leukemia (B-ALL), the most common type of pediatric cancer, compared to other publicly available fusion detection algorithms.

15 May 2026

Scientists discover a potential new way to slow ALS disease progression

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes the progressive loss of motor neurons, which in most cases leads to respiratory failure within three to five years after diagnosis.

30 Apr 2026

New biomarker predicts prognosis and treatment response in colorectal cancer

Determining the presence of a protein in non-tumor cells within the cancer microenvironment could be one of the keys to establishing prognosis in patients with colon and rectal cancer.

14 Apr 2026

Xuebijing injection reduces inflammation and ferroptosis in acute lung injury

Using an LPS-induced ALI mouse model and LPS-stimulated alveolar macrophages, they found XBJ reduced inflammatory cytokine surges, preserved alveolar barrier integrity, and limited tissue injury, while probing the molecular pathways and intracellular targets underlying these benefits.

7 Apr 2026