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Faulty cellular recycling may link pulmonary arterial hypertension to brain damage

A commentary in The Journal of Clinical Investigation examines evidence linking pulmonary arterial hypertension (PAH) to cerebellar abnormalities, focusing on impaired lysosomal lipid metabolism, oxysterol accumulation, and microglial inflammation. Findings from human imaging, mouse models, and cultured cells suggest that NCOA7 may help protect against these changes, although the proposed mechanisms and therapeutic implications require further investigation.

4 Nov 2026

Researchers develop method to generate billions of cDC1 immune cells

Conventional type 1 dendritic cells, known as cDC1 cells, are immune cells that help initiate responses against intracellular pathogens and tumors.

4 Nov 2026

Gq-coupled receptors activate cAMP signaling to regulate brain synapses

By studying G protein–coupled receptors (GPCRs) in mouse hippocampal slices, Qi Ding and colleagues provide evidence of unconventional receptor signaling that has implications for the function of synapses in the brain.

3 Nov 2026

New host target identified to block hepatitis E virus

Hepatitis E virus (HEV) is a major cause of acute viral hepatitis, yet antiviral treatment remains largely limited to the off-label use of ribavirin. Ribavirin can cause substantial toxicity, is contraindicated during pregnancy and does not reliably benefit every patient.

29 Oct 2026

Amino acid restores power to last-resort antibiotics

Worldwide, antibiotic resistance is associated with millions of deaths every year, and the World Health Organization warns that the number of resistant infections is rising.

29 Oct 2026

Amyloid fibers help sperm deliver RNA to mouse embryos

Researchers identified RNA-associated amyloid fibrils in human seminal fluid and demonstrated that synthetic PAP fibrils could enter mammalian sperm. In mouse IVF experiments, these fibrils helped sperm deliver RNA to embryos, where the detected reporter-protein signal was at least tenfold higher than without fibril exposure.

27 Oct 2026

The impact of vibration on microscopy

Environmental vibration affects microscopy image quality, experimental accuracy and reproducibility, and how isolation technologies can help.

From TMC Vibration Control 27 Oct 2026

Smart probe makes aggressive breast cancer cells glow during surgery

Surgical removal of a tumor remains the primary defense against most solid cancers. However, for surgeons in the operating room, differentiating between the outer edges of a tumor and healthy tissue is a challenge.

26 Oct 2026

invIOs publishes positive clinical data on CBL-B-silenced autologous cell therapy APN401 in peer-reviewed journal

invIOs GmbH (“invIOs”), a privately held biotechnology company developing innovative cancer immunotherapies, today announced the publication of new clinical data with its autologous PBMC (peripheral blood mononuclear cell) therapy APN401 in the peer-reviewed journal, Molecular Therapy Oncology.

16 Oct 2026

Researchers identify molecular pathway that improves ultrasound-based bone defect healing

Researchers from Capital Medical University, Beijing, China, have identified a CaN/NFATC3/Id3/E2A/Bmp4 signaling pathway that helps explain how low-intensity pulsed ultrasound (LIPUS) promotes bone regeneration.

15 Oct 2026

Molecular regulator CA8 may offer new therapeutic target for type 2 diabetes

Maintaining healthy blood glucose levels involves striking a balance between the glucose produced by the liver during fasting, and the insulin released from pancreatic beta cells after meals.

9 Oct 2026

High expression of CTDNEP1 gene linked to poorer kidney cancer survival

Renal cell carcinoma (RCC) is the most common form of kidney cancer, accounting for about 90% of kidney cancers.

7 Oct 2026

Streamlining CRISPR workflows, from editing to analysis

INTEGRA's automated solutions optimize CRISPR workflows, enhancing gene editing efficiency and accelerating the path to innovative therapeutic developments.

From INTEGRA Biosciences 30 Sep 2026

New study explains how TMEM63B protein regulates cell membranes

An autoinhibitory domain in the C-terminal tail of the TMEM63B, a mechanosensitive lipid scramblase, helps maintain its inactive state under resting conditions, report researchers from Institute of Science Tokyo.

29 Sep 2026

Scientists find new way to overcome cell’s natural defenses against self-amplifying mRNA vaccines

The innovation could enable protection at lower doses, meaning vaccines could be rolled out further and faster than was previously imaginable, and opens new possibilities in gene therapy, cancer immunotherapy, and protein replacement therapies.

28 Sep 2026

Existing drug helps bladder cells destroy hidden urinary tract infections

Urinary tract infections, or UTIs, are among the most common bacterial infections, caused mostly by the uropathogenic bacterium Escherichia coli. But even after antibiotic treatment, a large number of patients experience another UTI.

25 Sep 2026

New project aims to make cellular therapies more accessible through room temperature storage

The Advanced Research Projects Agency for Health, or ARPA-H, has executed an award of up to $36.5 million in support of a University of California, Davis-led project aiming to make cellular therapies cheaper and more accessible through room temperature storage.

25 Sep 2026

Study identifies bile acid that helps reduce excess fat accumulation in the liver

Non-alcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction-associated steatotic liver disease (MASLD), is a common condition that causes excess fat to build up in the liver, affecting about one-quarter of adults worldwide.

17 Sep 2026

KAIST team uncovers how neurons deliver RNA to distant regions

Much like a courier reading an address on a package, neurons must deliver RNA to the precise locations where it is needed.

15 Sep 2026

Gut infection leaves long-lasting immune ‘memories’ at the brain’s borders in mice

In mice, intestinal infections reshaped dural CD4+ T-cell populations and seeded the brain’s outer meningeal border with antigen-specific memory cells that persisted for months and mounted rapid recall responses to bloodborne antigens. Oral priming was associated with reduced Salmonella spread to the brain and modest cross-protection in an engineered shared-antigen Candida model, although the researchers could not definitively prove that dural CD4+ T cells alone caused the protection.

9 Sep 2026

Intracellular News and Research

Faulty cellular recycling may link pulmonary arterial hypertension to brain damage

Researchers develop method to generate billions of cDC1 immune cells

Gq-coupled receptors activate cAMP signaling to regulate brain synapses

New host target identified to block hepatitis E virus

Amino acid restores power to last-resort antibiotics

Amyloid fibers help sperm deliver RNA to mouse embryos

The impact of vibration on microscopy

Smart probe makes aggressive breast cancer cells glow during surgery

invIOs publishes positive clinical data on CBL-B-silenced autologous cell therapy APN401 in peer-reviewed journal

Researchers identify molecular pathway that improves ultrasound-based bone defect healing

Molecular regulator CA8 may offer new therapeutic target for type 2 diabetes

High expression of CTDNEP1 gene linked to poorer kidney cancer survival

Streamlining CRISPR workflows, from editing to analysis

New study explains how TMEM63B protein regulates cell membranes

Scientists find new way to overcome cell’s natural defenses against self-amplifying mRNA vaccines

Existing drug helps bladder cells destroy hidden urinary tract infections

New project aims to make cellular therapies more accessible through room temperature storage

Study identifies bile acid that helps reduce excess fat accumulation in the liver

KAIST team uncovers how neurons deliver RNA to distant regions

Gut infection leaves long-lasting immune ‘memories’ at the brain’s borders in mice

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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