Liquid Chromatography News and Research

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Could the type of fiber children eat matter for their developing gut microbiome?

A recent study found that different dietary fibers can shape the composition and activity of the gut microbiome during early childhood, with xyloglucan, arabinoxylan, and pectin increasing short-chain fatty acid production in laboratory fermentation experiments. Some fibers also supported gut barrier measures and altered inflammatory responses, while observational data linked higher pectin intake with greater microbial diversity in young children.

31 Aug 2026

New framework standardizes selenosugar research and selenium metabolism studies

Selenosugars are the major urinary metabolites responsible for the physiological excretion of selenium. Understanding selenium metabolism relies on accurately detecting and identifying selenosugars.

20 Aug 2026

Early-life stress rewires brain epigenetics to heighten sensitivity to future stress

. Early-life stress increased SETD7 and H3K4me1 in the ventral tegmental area of mice, creating an epigenetically primed state that heightened later transcriptional, neuronal, and behavioral responses to stress. Reducing Setd7 during development lowered H3K4me1 and weakened these stress-sensitizing effects, identifying a mechanism that may help explain how early adversity leaves lasting biological effects.

11 Aug 2026

Voltammetry and machine learning for real-time neurotransmitter detection

Anne Andrews (UCLA) explains how voltammetry and machine learning can track multiple neurotransmitters in real time, even with overlapping signals.

From Pittcon 10 Aug 2026

A common dietary nutrient feeds a gut pathway linked to atrial fibrillation

Researchers linked higher plasma TMAO to prevalent atrial fibrillation in 5,090 people and found that TMAO or choline supplementation accelerated AF onset, progression, atrial remodeling, and electrical dysfunction in mice. Inhibiting gut microbial TMA production lowered circulating TMAO and delayed AF in mice, identifying a potential therapeutic pathway that now requires human testing.

27 Jul 2026

Spermidine boosts key cellular processes linked to aging in early research

This review finds that spermidine supports autophagy, mitochondrial function, and healthspan in experimental models, while observational studies link higher dietary intake to lower mortality. However, human trials have produced limited and mixed results, leaving its clinical role in healthy aging unresolved.

23 Jul 2026

Stuffed toys can release short-chain PFAS into saliva, study finds

Researchers tested 18 stuffed toys and found that all released at least one targeted PFAS into artificial saliva under mouthing-relevant conditions, with PFHxA driving much of the variation between products. Modeled intake of the four PFAS covered by EFSA’s group tolerable weekly intake remained below that benchmark, but some high-PFHxA toys had reduced margins of exposure, and water rinsing produced mixed results.

22 Jul 2026

Novogene Europe launches Untargeted Metabolomics Service at Cambridge Omics Centre

Novogene Europe, a multiomics research services partner, today announced that it has strengthened its position as a multiomics partner with the launch of its Untargeted Metabolomics Service through its Cambridge Omics Centre.

From Novogene Europe 13 Jul 2026

Cold-exposed mothers pass metabolic protection to male rat offspring through milk

Maternal cold exposure during early pregnancy improved glucose control and reduced liver fat in male rat offspring, with benefits persisting into late adulthood. The findings implicate a breast milk LCA, gut microbiota, and Th17 immune pathway, while human cohort data showed an observational link between winter conception and lower MASLD risk.

12 Jul 2026

Smoking shows no major impact on the eye microbiome in small study

A small study found no evidence that smoking causes large or consistent shifts in the ocular surface microbiome or tear proteome. The authors caution that subtle smoking-related effects cannot be ruled out, given the small cohort and the ocular surface's low-biomass, contamination-sensitive microbial niche.

8 Jul 2026

Trial identifies 4 grams a day as the tested safe level for L-tyrosine in healthy men

A randomized, crossover trial in healthy adult men found that 4 weeks of L-tyrosine supplementation at doses up to 4 g/day did not cause clinically meaningful changes in safety markers, diet, blood pressure, or body measures. The highest tested dose, 4 g/day, was identified as the no-observed-adverse-effect level under the study’s four-week conditions, although broader and longer-term studies are still needed.

23 Jun 2026

Optimized proximity labeling platform tracks cellular protein communication networks

The body's organs are in constant communication. Fat tissue tells the liver when to store or release energy, the immune system signals localized inflammation, and thousands of proteins carry these messages to organs throughout the body.

22 Jun 2026

PMOS rethink reframes a common hormone disorder as a whole-body disease

A new review reframes PCOS, now proposed as PMOS, as a systemic endocrine and metabolic disorder shaped by genetic, epigenetic, ovarian, metabolic, and neuroendocrine pathways. It highlights why inconsistent diagnosis and symptom-focused care have limited progress, while targeted therapies, biomarkers, machine learning, and organ-on-chip models may support more personalized treatment.

18 Jun 2026

Gut bacteria may help explain why fatigue appears before illness

A small study of healthy Japanese adults found that fatigue was associated with distinct gut microbiome, microbial gene, and fecal metabolite patterns. The findings suggest fatigue may track with altered microbial energy metabolism and oxidative stress-related functional potential, but larger longitudinal studies are needed to test causality and clinical value.

16 Jun 2026

Urine drug test may boost adherence to blood pressure medications

The largest ever UK trial of a urine test used across the NHS to spot when patients skip their medication has shown it may improve adherence to treatment.

12 Jun 2026

Advancing Cushing's syndrome diagnosis with salivary cortisone testing

Discover expert insights into Cushing's syndrome diagnosis using salivary cortisone testing and LC-MS/MS for improved accuracy.

From Waters Advanced Diagnostics 10 Jun 2026

Untargeted metabolomics approach identifies potential biomarkers for latent tuberculosis diagnosis

Announcing a new article publication in BIO Integration. Latent tuberculosis infection (LTBI) is difficult to diagnose due to the lack of a definitive gold standard.

5 Jun 2026

Southwest Research Institute evaluates NASA's medication handling practices

Southwest Research Institute evaluated NASA's medication handling practices, which currently call for removing medications from their original packaging and storing them in resealable plastic bags.

2 Jun 2026

Urine-based autism screening using gut microbial metabolites

Elevated gut microbe metabolites may distinguish children with autism, paving the way for a non-invasive urine test and a new ASD subtype linked to microbiome.

29 May 2026

Gut changes linger years after polyp removal and may signal colorectal cancer risk

Researchers found that women who had undergone colorectal adenoma resection still showed gut microbiome and fecal metabolome alterations an average of about 12 years later. These persistent changes partly resembled colorectal cancer-associated patterns, suggesting that the host-microbiome axis may remain altered along the adenoma-cancer continuum.

28 May 2026