Low Testosterone News and Research

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Too little or too much testosterone may matter for heart rhythm

A review of clinical trials, observational studies, genetic analyses, and mechanistic research suggests that atrial fibrillation risk may follow a U-shaped relationship with testosterone, increasing at both low and high levels. Evidence on testosterone replacement therapy remains mixed, with researchers calling for prospective studies to determine whether mid-physiological testosterone targets and treatment formulation influence AF risk.

2 Sep 2026

ReproNovo announces first participant dosed in EU Phase 2 trial of RPN-002 for embryo implantation

ReproNovo, a clinical-stage biopharmaceutical company committed to addressing critical gaps in male and female fertility as well as women’s health, today announced that the first participant has been dosed in the Company’s EU Phase 2 clinical trial of RPN-002, entitled Nolasiban Optimized Regimen Dosing for Inhibition of Uterine Contractility (NORDIC).

6 Jul 2026

GLP-1s may improve testosterone levels and sperm quality in men with obesity

GLP‑1s do not harm male hormones or fertility after long-term use, according to a study being presented Monday at ENDO 2026, the Endocrine Society's annual meeting in Chicago, Ill.

15 Jun 2026

AI-driven hormone tracking could help detect infertility early and improve conception

Men and women who appear hormonally 'normal' may still have undetected disruptions in the timing and coordination of their reproductive hormones that could impair fertility, according to research presented at the 28th European Congress of Endocrinology in Prague.

8 May 2026

As US birth rate falls, feds’ response may make pregnancy more dangerous

The number of babies born in the United States fell again last year.

17 Apr 2026

Testosterone level is not always the key to male wellbeing

The connection between testosterone and well-being is weaker than many people think. Although there are clear health connections, a higher testosterone level is not always the key to well-being, according to a thesis at the University of Gothenburg.

31 Mar 2026

Low testosterone and high fructose intake can worsen fatty liver disease

Low testosterone in itself can cause a variety of health problems, but the addition of a poor diet can exacerbate certain conditions. Metabolic dysfunction-associated steatotic liver disease (MASLD) is one example that approximately 40% of adult men worldwide currently suffer from and has become a global problem.

11 Mar 2026

Low baseline testosterone predicts aggressive prostate cancer progression risk

A new study led by researchers at The University of Texas MD Anderson Cancer Center found that prostate cancer patients with low testosterone levels may have a higher risk of cancer progressing to a more aggressive form while under active surveillance.

10 Mar 2026

Why “low testosterone” has become a profitable masculinity crisis online

Social media's portrayal of low testosterone transforms masculinity into a marketable issue, linking health interventions to male identity and performance.

6 Feb 2026

Indiana University physician joins FDA panel on male hormone therapy

Helen Bernie, DO, MPH, assistant professor of urology at Indiana University School of Medicine, will participate in an expert panel on testosterone replacement therapy and men's health to be held Wednesday, Dec. 10, by the U.S. Food and Drug Administration. Bernie's role on the panel is that of a clinical expert on men's reproductive health, which is the focus of both her practice and academic research.

12 Dec 2025

Lifestyle choices and hormonal imbalances can impact men's reproductive health

A new research paper was published in Volume 12 of Oncoscience on September 30, 2025, titled "Lifestyle and hormonal factors affecting semen quality and sperm DNA integrity: A cross-sectional study."

10 Oct 2025

Study reveals how SARS-CoV-2 hijacks testicular lipid metabolism to replicate

The COVID-19 virus hijacks the machinery of testicular cells that produce the hormone testosterone in order to replicate.

21 Aug 2025

Weight loss drugs can boost testosterone in men with obesity or diabetes

Anti-obesity medications can significantly raise testosterone levels and improve health outcomes for men with obesity or type 2 diabetes, according to a new study being presented Monday at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

14 Jul 2025

Low testosterone linked to higher kidney stone risk in men, study finds

A large cross-sectional study in South Korea found that men with low testosterone levels (below 3.33 ng/mL) were significantly more likely to have kidney stones. This association held even after adjusting for age and metabolic risk factors, suggesting testosterone may play a protective role.

6 May 2025

Exploring the relationship between testosterone and men's health

The review article titled"Testosterone and men's health: An in-depth exploration of their relationship", was published on February 18, 2025 in UroPrecision.

2 Apr 2025

Testosterone treatment can save lives for men with Klinefelter syndrome

Testosterone treatment significantly reduces mortality among men with Klinefelter syndrome. Researcher calls for changes in guidelines to ensure more patients receive the necessary treatment.

13 Feb 2025

The hidden effects of opioid use on the endocrine system

A new Scientific Statement released today by the Endocrine Society highlights research gaps associated with the negative effects of opioid use on the endocrine system.

25 Oct 2024

Insights into testosterone recovery after androgen deprivation therapy for prostate cancer

A study led by researchers from the UCLA Health Jonsson Comprehensive Cancer Center sheds light on testosterone recovery following androgen deprivation therapy (ADT) in men undergoing radiotherapy for prostate cancer, providing key insights for optimizing patient care.

26 Sep 2024

One-third of former professional American football players report a punch-drunk reality - CTE

Study found that one-third of former American football players reported perceived CTE, which was significantly associated with a higher risk of suicidality and mental health problems.

25 Sep 2024