Metabolic Disorders News and Research

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The Mediterranean diet has a modern problem, and it isn't just about food

A narrative review published in Applied Sciences examined how urbanisation, time constraints, food costs, and changing lifestyles have contributed to declining adherence to the Mediterranean diet. Drawing on 116 references, the authors identified workplace and school interventions, nutrition education, physical activity, and Mediterranean-inspired convenience foods as potential strategies for adapting this dietary pattern to modern life.

5 Nov 2026

Hidden genetic differences in gut bacteria may hold clues to aging

Researchers analyzed approximately 12.8 million gut microbial genetic variants in 10,781 individuals across six cohorts, identifying 940 independent associations with 69 human health characteristics and environmental exposures. Nearly two-thirds of these associations were not accompanied by significant differences in bacterial species abundance, suggesting that microbial genetics can reveal relationships overlooked by conventional microbiome analyses, although causality remains unproven.

5 Nov 2026

Review examines translational bottlenecks for plant-derived anti-inflammatory compounds

A review led by Professor Weidong Zhang at the School of Pharmacy, Naval Medical University, was published in Volume 2 of the journal Immunity & Inflammation on October 27, 2026. The article systematically examines the translational bottlenecks and potential solutions for plant-derived anti-inflammatory compounds.

5 Nov 2026

Faulty cellular recycling may link pulmonary arterial hypertension to brain damage

A commentary in The Journal of Clinical Investigation examines evidence linking pulmonary arterial hypertension (PAH) to cerebellar abnormalities, focusing on impaired lysosomal lipid metabolism, oxysterol accumulation, and microglial inflammation. Findings from human imaging, mouse models, and cultured cells suggest that NCOA7 may help protect against these changes, although the proposed mechanisms and therapeutic implications require further investigation.

4 Nov 2026

Insilico Medicine leader shares AI-driven drug discovery insights in Shanghai and Dubai

Dr. Jue Wang, Head of Global Business Development at Insilico Medicine, has been invited to attend the China Healthcare Summit in Shanghai. On the afternoon of November 3 at 16:45, she will deliver a keynote speech in the panel titled: "THE COMMODITIZATION TRAP: WHO WINS WHEN EVERYONE HAS THE SAME AI?"

30 Oct 2026

Newly discovered protein helps preserve egg chromosome integrity during aging

Eggs follow a very different developmental path from sperm. Once a male hits puberty, sperm cells are produced continuously throughout his life.

29 Oct 2026

Ketones may change sleep patterns, but not always for the better

Researchers reviewed animal and human studies and found that ketone bodies may affect sleep stages through energy metabolism and cellular signaling, with the clearest direct evidence involving acetoacetate in mice. They reported mixed human findings and called for controlled studies to separate ketone-specific effects from changes linked to diet, disease, circadian timing, and physiological stress.

28 Oct 2026

Review highlights essential neurological considerations for gender dysphoria care

Gender dysphoria involves distress caused by a mismatch between a person's gender identity and sex assigned at birth.

28 Oct 2026

Proteins linked to Alzheimer's found to assist sperm cells

Unexpectedly, a kind of protein that is usually linked with diseases in the brain may play a vital role in semen, helping shepherd genetic material into sperm cells, scientists at Columbia's Zuckerman Institute report today in the research journal Molecular Cell.

26 Oct 2026

Modulating GPCR signaling could help delay multiple age-related diseases

Researchers have outlined a bold plan for slowing aging by targeting one of the body's most important cellular communication systems.

22 Oct 2026

Greenwood Genetic Center researcher wins major grant to explore cellular metabolism and glycosylation

Heather Flanagan-Steet, PhD, Associate Director of Research at the Greenwood Genetic Center (GGC), has received a $1.4 million, five-year Maximizing Investigators' Research Award (MIRA) R35 grant from the National Institutes of Health's National Institute of General Medical Sciences.

21 Oct 2026

Researchers investigate molecular mechanisms linking high-calorie diets to cognitive decline

The molecular mechanisms linking a high calorie diet to cognitive impairment remain unclear. Researchers at Institute of Science Tokyo, Japan, investigated this association in mice, finding that the diet reduced nuclear protein PQBP1 expression, disrupting the alternative splicing of genes involved in synaptic function.

20 Oct 2026

UCL study reveals broad mortality risks faced by ADHD individuals

For the study, published in JAMA Network Open, the researchers conducted a systematic review and meta-analysis of 19 studies that included data from close to 16 million study participants on three continents.

19 Oct 2026

Novel bioprinting technique successfully replicates mature human fat tissue

A research team has developed a support-bath bioprinting method that enables fragile, mature human adipocytes to be incorporated into geometrically defined three-dimensional (3D) constructs while retaining their viability, characteristic lipid-filled morphology, and metabolic activity.

14 Oct 2026

Women with polyendocrine metabolic ovarian syndrome more likely to have Alzheimer's and dementia

Alzheimer's disease and dementia may be more common in women with polyendocrine metabolic ovarian syndrome (PMOS), formerly known as polycystic ovary syndrome (PCOS), according to a review of existing evidence published in the Journal of the Endocrine Society.

13 Oct 2026

Targeting lipophagy could help treat metabolic and oxidative stress-related diseases

A review published in Genes & Diseases highlights lipophagy, the cellular process that selectively breaks down lipid droplets, as a potentially important therapeutic target for conditions driven by disrupted lipid metabolism and oxidative stress.

12 Oct 2026

Nutritionally similar meals might not affect your body the same way

Ultra-processed foods trigger distinct metabolic and brain responses, influencing insulin release and nutrient processing despite similar nutritional content.

8 Oct 2026

Study uncovers link between inherited blindness and a gene causing rare metabolic disease

Researchers at the Greenwood Genetic Center (GGC) led the discovery of an unexpected connection between inherited blindness and a gene known for causing a rare metabolic disorder.

6 Oct 2026

Fluorescent sensors could help researchers see diabetes in action

Researchers from the University of Bath have developed fluorescent molecular probes that can detect changes in glucose levels inside living animals, giving scientists new ways of visualizing sugar uptake, studying diabetes, cancer and other metabolic diseases in whole organisms in real time.

1 Oct 2026

Researchers found a curious mitochondrial pattern in people who moved more

Researchers found that greater self-reported activity, walking, and accelerometer-measured light activity were associated with higher mitochondrial DNA copy number in 256 healthy middle-aged adults. The cross-sectional findings cannot establish causation, and the very low amount of vigorous activity means they do not show that light movement is more beneficial than higher-intensity exercise.

29 Sep 2026

Metabolic Disorders News and Research

The Mediterranean diet has a modern problem, and it isn't just about food

Hidden genetic differences in gut bacteria may hold clues to aging

Review examines translational bottlenecks for plant-derived anti-inflammatory compounds

Faulty cellular recycling may link pulmonary arterial hypertension to brain damage

Insilico Medicine leader shares AI-driven drug discovery insights in Shanghai and Dubai

Newly discovered protein helps preserve egg chromosome integrity during aging

Ketones may change sleep patterns, but not always for the better

Review highlights essential neurological considerations for gender dysphoria care

Proteins linked to Alzheimer's found to assist sperm cells

Modulating GPCR signaling could help delay multiple age-related diseases

Greenwood Genetic Center researcher wins major grant to explore cellular metabolism and glycosylation

Researchers investigate molecular mechanisms linking high-calorie diets to cognitive decline

UCL study reveals broad mortality risks faced by ADHD individuals

Novel bioprinting technique successfully replicates mature human fat tissue

Women with polyendocrine metabolic ovarian syndrome more likely to have Alzheimer's and dementia

Targeting lipophagy could help treat metabolic and oxidative stress-related diseases

Nutritionally similar meals might not affect your body the same way

Study uncovers link between inherited blindness and a gene causing rare metabolic disease

Fluorescent sensors could help researchers see diabetes in action

Researchers found a curious mitochondrial pattern in people who moved more

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