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Modified zinc finger scaffold suppresses microglial activation in mouse brain

A KAIST-led research team has found that a protein involved in gene regulation can suppress the harmful aggregation of amyloid-beta, a peptide associated with Alzheimer's disease. The approach also reduced the toxicity of protein aggregates that had already formed.

5 Nov 2026

Faulty cellular recycling may link pulmonary arterial hypertension to brain damage

A commentary in The Journal of Clinical Investigation examines evidence linking pulmonary arterial hypertension (PAH) to cerebellar abnormalities, focusing on impaired lysosomal lipid metabolism, oxysterol accumulation, and microglial inflammation. Findings from human imaging, mouse models, and cultured cells suggest that NCOA7 may help protect against these changes, although the proposed mechanisms and therapeutic implications require further investigation.

4 Nov 2026

Scientists may have underestimated how much genes contribute to Alzheimer's risk

A large multi-ancestry genetic analysis identified 127 genomic loci associated with Alzheimer's disease, including 48 previously unreported loci, and implicated microglial and neuronal gene-expression patterns in disease susceptibility. The researchers estimated that common genetic variants account for 16% of Alzheimer's disease liability in European-ancestry populations, substantially higher than previous estimates, while demonstrating improved polygenic risk prediction that remained less reliable in non-European populations.

2 Nov 2026

Study uncovers why pulmonary hypertension patients report symptoms of cognitive decline

University of Pittsburgh and UPMC researcher-clinicians have uncovered why many pulmonary hypertension patients report symptoms of cognitive decline.

2 Nov 2026

Large genetic study uncovers new risk factors for Alzheimer's

A large-scale international study, led by Ole Andreassen at University of Oslo and Oslo University Hospital, in collaboration with international consortium, offers new insights for understanding the disease and developing future treatments.

29 Oct 2026

Blocking cellular communication reduces the spread of deadly glioblastoma

In a new study published in Cancer Cell, researchers at VIB-KU Leuven reduced the spread of glioblastoma by interrupting specific interactions between the brain's immune cells and tumor cells.

27 Oct 2026

Altered fatty acid metabolism drives glioblastoma growth and treatment resistance

Glioma is the most common primary malignant brain tumor in adults, and glioblastoma (GBM), particularly IDH (Isocitrate dehydrogenase)-wildtype disease, has the poorest prognosis.

21 Oct 2026

A protective brain enzyme may counteract aging-associated cognitive decline

Cinzia Vicidomini, PhD, and Amar Sahay, PhD, of the Mass General Brigham Department of Psychiatry, the Harvard Stem Cell Institute and the Broad Institute of Harvard and MIT, are the lead and senior authors of a paper published in Nature Neuroscience, "An aging-sensitive secreted phospholipase confers neuroprotection and cognitive resilience."

15 Oct 2026

Brain injuries change how the hypothalamus responds to stress

Researchers from the Department of Cell Biology, Genetics and Physiology at the University of Malaga have led an international scientific team that has studied how a traumatic brain injury caused by a severe blow to the head conditions the brain's long-term response to subsequent stress situations.

9 Oct 2026

Study uncovers a protective role for microglia in Parkinson's disease

Researchers at the University of Oxford have uncovered a previously unrecognized protective role for microglia, the brain's resident immune cells, in Parkinson's disease.

7 Oct 2026

Existing drug could target neuroinflammation in Alzheimer's patients

Inflammatory conditions in the brain, including traumatic brain injury and degenerative diseases like Alzheimer's could be targeted with an existing drug thanks to new research that shows it can work in brain cells.

5 Oct 2026

Study explains how stroke promotes aggressive glioma tumor growth

Researchers at Texas Children's Duncan Neurological Research Institute (Duncan NRI), Baylor College of Medicine and collaborating institutions show in Nature Cancer that stroke promotes glioma growth and uncovered cellular and molecular mediators involved in the process, linking brain injury to malignant brain tumors.

25 Sep 2026

Blood proteins may help monitor Alzheimer’s treatment response

Patients with early symptoms of Alzheimer's disease may be prescribed anti-amyloid therapy, which can help clear the sticky clumps of amyloid protein in the brain that characterize Alzheimer's.

25 Sep 2026

GLP-1 drugs may influence chronic pain through gut-brain and immune pathways

Researchers reviewed evidence linking GLP-1 and GLP-1 receptor agonists to chronic pain modulation through gut microbial, neuroimmune, vagal, and metabolic pathways, with the strongest clinical evidence currently involving knee osteoarthritis and idiopathic intracranial hypertension headache. Much of the proposed biology remains supported by preclinical research, and human studies have yet to establish that GLP-1RA-induced changes in the gut microbiome directly cause pain relief.

24 Sep 2026

Adenine base editing slows neurodegeneration in hereditary motor neuron disease

A team of researchers led by Professor Haruhisa Inoue (Center for iPS Cell Research and Application, Kyoto University) and Professor Yuishin Izumi (Tokushima University) demonstrated that adenine base editing can correct a disease-causing genetic mutation and alleviate neurodegeneration in hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P), providing proof of concept for a precision gene therapy for inherited motor neuron diseases.

18 Sep 2026

Aging brain actively shapes biology and progression of tumors

Brain tumors develop within an organ that changes substantially with age. A new review in Ageing and Cancer Research & Treatment examines evidence that the aging brain microenvironment may influence brain tumor progression, treatment resistance, and cognitive outcomes.

10 Sep 2026

Bruker advances whole-organism 3D imaging with enhanced tissue-clearing workflows

Bruker Corporation today announced a strategic collaboration with Translucence Biosystems, Inc., a leading provider of tissue‑clearing solutions, to expand its workflow for cleared tissue imaging.

From Bruker Nano Surfaces and Metrology 10 Sep 2026

Compound PF-04457845 slows motor decline in ALS mouse models

Amyotrophic lateral sclerosis (ALS) is a severe neurological disease that destroys nerve cells responsible for muscle movement.

28 Aug 2026

Tea, berries and dark chocolate featured in a diet linked to lower Parkinson’s risk

A prospective UK Biobank study of 123,655 adults found that a dietary pattern richer in flavonoid-containing foods was modestly associated with a lower incidence of hospital-recorded Parkinson’s disease. The association was strongest among those with the highest flavonoid diet scores, while exploratory proteomic and transcriptomic analyses pointed to possible neuroimmune and cell-adhesion pathways but did not establish causality or mechanism.

26 Aug 2026

Molecular switch ERBB4 linked to broad range of Alzheimer's pathologies

What if amyloid plaques are not the whole story of Alzheimer's disease? New research suggests that a broad range of Alzheimer's pathologies may be orchestrated by a molecular switch called ERBB4 when it turns on in the wrong neurons.