Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

MIT biologists discover cellular pathway that triggers colon cancer spread

Most colon cancer deaths are caused by the spread of tumor cells beyond the colon, usually to the liver. In a new study, MIT biologists identified a cellular pathway necessary for colorectal cancer metastasis.

24 Sep 2026

MIT researchers build cell collection device for early cancer detection

One of the main reasons that ovarian cancer is among the deadliest forms of cancer is timing: When doctors catch it early, the five-year survival rate can be north of 90 percent.

24 Sep 2026

Slow-growing progenitor cells cause smooth brains in common marmosets

Most primate species have a relatively large brain with a surface marked by pronounced bulges and furrows. This is not the case with common marmosets (Callithrix jacchus). The brains of these small monkeys are smooth and virtually unfolded.

23 Sep 2026

Brain organoids reveal new clues for childhood epilepsy treatments

Tiny, year-old human brain organoids that mimic the brain of a newborn are providing new clues to potential treatments for a leading genetic cause of childhood epilepsy that typically manifests as the brain matures shortly after birth.

23 Sep 2026

Adenine base editing slows neurodegeneration in hereditary motor neuron disease

A team of researchers led by Professor Haruhisa Inoue (Center for iPS Cell Research and Application, Kyoto University) and Professor Yuishin Izumi (Tokushima University) demonstrated that adenine base editing can correct a disease-causing genetic mutation and alleviate neurodegeneration in hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P), providing proof of concept for a precision gene therapy for inherited motor neuron diseases.

18 Sep 2026

Transplanted human cortical organoids filled most of a mouse cortex. Then they began to connect

Researchers created xenocortical mice by transplanting human cortical organoids into animals genetically depleted of much of their native cortex, allowing the human tissue to occupy most of the available cortical space and form anatomical connections throughout the host nervous system. The grafts developed diverse cortical cell types, including L5-ET and VEN-like neurons, generated organized neural activity, and produced measurable cellular and behavioral responses to hypoxic injury.

18 Sep 2026

New funding supports LMU research on pediatric inflammatory bowel disease

The non-profit Boehringer Ingelheim Stiftung supports LMU clinician-scientist Daniel Kotlarz through its Rise up! program.

10 Sep 2026

New AI model decodes chemical signals guiding embryonic cell development

As an embryo develops from a small cluster of stem cells, those once "blank slate" cells begin to take on more specialized roles like brain, liver, or muscle cells, and organize themselves into three-dimensional structures such as tissues and organs.

8 Sep 2026

Crucial brain stem cells rely on metabolic pathways to make decisions

As the human brain takes shape before birth, a remarkable type of stem cell helps give it many of the features that make it distinctly human.

4 Sep 2026

Bridging science and family story to understand schizophrenia origins

Twin studies have placed the heritability of schizophrenia at roughly eighty percent for decades. Concordance between identical twins, who share the entire genome, does not reach fifty percent. Both figures are well established, and they do not fit together comfortably.

2 Sep 2026

Blocking a key protein protects against metabolic liver damage

Obesity-related metabolic liver disease affects hundreds of millions of people worldwide, but only some fraction of those livers develop scarring, become inflamed, and eventually fail. University of Utah researchers have identified a protein, EFHD1, that appears to drive that transition by triggering an out-of-place antiviral immune response.

1 Sep 2026

Researchers identify early molecular warning signs of inflammatory bowel disease

Researchers have uncovered early molecular warning signs of inflammatory bowel disease, revealing the condition can begin before symptoms appear and continue silently even when patients appear well.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 29 Aug 2026

Primate-specific DNA change reveals a new link to dementia-related neurodegeneration

Brain diseases, including dementia, have long been studied using experimental animals such as mice. However, differences between the human and animal genomes have raised concerns that some disease mechanisms may not be fully explained by conventional animal models.

29 Aug 2026

UCSF scientists build largest molecular interaction map for autism

For more than two decades, researchers have identified hundreds of genes that increase the risk of autism spectrum disorder (ASD).

28 Aug 2026

Brain organoids reveal how Alu-mediated gene deletion can lead to neurodegeneration

Brain diseases, including dementia, have long been studied using experimental animals such as mice.

27 Aug 2026

Nanoparticles regenerate neurons and improve cognition in Alzheimer’s mice

The adult human brain has limited capacity to repair or regenerate neurons lost to Alzheimer's disease, the most common type of dementia.

26 Aug 2026

Scientists create brain organoids with distinct cortical regional identity

The human brain is often described as one of the most complex structures in biology, and much of its power comes from how it's organized.

20 Aug 2026

Researchers maintain brain organoids for longer than ever before

An international team of researchers has maintained brain organoids, three-dimensional models of human brain tissue, for longer than ever before.

20 Aug 2026

Brain organoid studies on the ISS move closer to new treatments

Research using human brain organoids onboard the International Space Station International Space Station (ISS) helped lead to the clinical trial of a potential therapy for Rett syndrome, a debilitating neurological disorder in children.

20 Aug 2026

Computational pipeline uncovers subtype specific targets for cervical cancer

A new study presents a multi-layered strategy for identifying cell-surface targets that could help guide more precise antibody-drug conjugate (ADC) development for cervical cancer, with different targets showing distinct potential across tumor subtypes.

17 Aug 2026