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Targeted diet helps reprogram aggressive neuroblastoma in mice

Researchers highlighted how an arginine- and proline-restricted diet combined with eflornithine reprogrammed MYCN-driven neuroblastoma in mice, pushing tumor cells out of the cell cycle and toward differentiation. The commentary argues that this metabolism-to-translation link could open a new path for testing targeted dietary strategies alongside cancer drugs in future clinical studies.

9 Apr 2026

Myosteatosis: An emerging predictor of outcomes in chronic liver disease

Myosteatosis, the pathological infiltration of fat into skeletal muscle, is increasingly recognized as a key predictor of poor clinical outcomes across a spectrum of liver diseases.

22 Jan 2026

Molecular fingerprint predicts physical fitness in older adults

Could a simple blood test reveal how well someone is aging? A team of researchers led by Wolfram Weckwerth from the University of Vienna, Austria, and Nankai University, China, has combined advanced metabolomics with cutting-edge machine learning and a novel network modeling tool to uncover the key molecular processes underlying active aging.

30 Sep 2025

How a single gene reshapes pain perception through polyamine signaling

Researchers have identified SLC45A4 as a neuronal polyamine transporter genetically linked to human chronic pain. Loss of this gene in mice disrupts polyamine balance, alters spinal GABA levels, and reduces heat and tonic pain sensitivity.

24 Aug 2025

NUCDF launches national project to advance urea cycle disorder research

The National Urea Cycle Disorders Foundation, the leading patient advocacy group for people affected by urea cycle disorders (UCDs), today announced the launch of a two-year national project to establish the multistakeholder NUCDF Partner Network and develop a roadmap for future research in these rare disorders.

19 Jun 2025

Breakthrough method creates functional liver organoids

While organoids aim to mimic human organs, the liver's repertoire of complex functions – and thus the energy it needs to operate – have made it challenging for researchers to grow organoids that proliferate and fully function, says Sato. When prioritizing growth and survival in laboratory settings, hepatocytes, the liver's main cells, eventually transformed into cells resembling cholangiocytes, which line the bile duct.

16 Apr 2025

Study uncovers blood signatures linked to Sudden Infant Death Syndrome

New University of Virginia School of Medicine research revealing the fingerprints of Sudden Infant Death Syndrome within blood samples could open the door to simple tests to identify babies at risk.

22 Jan 2025

Research sheds light on Salmonella’s ability to escape gut defenses

A new UC Davis Health study has uncovered how Salmonella bacteria, a major cause of food poisoning, can invade the gut even when protective bacteria are present.

15 Nov 2024

Mitochondria’s division of labor sheds light on how cancer cells survive harsh conditions

Research shows mitochondria form distinct subpopulations under nutrient stress, revealing survival mechanisms in cancer cells and potential therapeutic targets.

12 Nov 2024

Early bedtime boosts children's gut health by increasing beneficial bacteria

Study reveals that children who go to bed early have a more diverse and healthier gut microbiome compared to late sleepers, suggesting a link between sleep habits and gut health. It also highlights key metabolic pathways that differ between early and late sleepers.

8 Oct 2024

New brain atlas reveals hidden cell vulnerabilities in Alzheimer's

Researchers created a detailed transcriptomic atlas of six brain regions, revealing cell-type-specific and region-specific vulnerabilities in Alzheimer's disease and highlighting astrocyte genes linked to cognitive resilience.

25 Jul 2024

Oral bacteria interaction leads to smelly breath

Having bad breath really stinks! Now, researchers from Japan report that a particular combination of bacteria in our mouths may be responsible for producing some very unpleasant smells.

14 Feb 2024

Is the microbiome linked to post-traumatic stress disorder outcomes?

The potential role of the microbiome-gut-brain axis in this interaction.

21 Nov 2023

The interplay between the microbiota, the epigenome, and nutrition among obese adults during behavioral weight reduction

Study evaluated associations between gut microbiome (MB), deoxyribonucleic acid (DNA) methylation (DNAme), and nutrition.

21 Aug 2023

A computational model identifies metabolites associated with Parkinson's disease

Researchers identify significant metabolites involved in the development and progression of Parkinson’s disease.

15 Aug 2023

Gut microbiota holds clues to predicting Alzheimer's risk

Gut microbiome alterations in preclinical Alzheimer's disease (AD) were investigated, revealing distinct taxonomic composition and potential markers of AD risk. These findings contribute to understanding AD pathology and offer insights into gut-derived markers for AD.

15 Jun 2023