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Mount Sinai researchers discover how Alzheimer's gene damages blood vessels

Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease.

24 Sep 2026

Duke engineers grow retinal blood vessel cells from pluripotent stem cells

Biomedical engineers at Duke University have used induced pluripotent stem cells (iPSCs) to grow specialized blood vessel cells critical to retinal health for the first time.

30 Jun 2026

Study identifies key fibrotic cells driving hypertrophic scars

Hypertrophic scars (HS) are abnormal outcomes of wound healing, marked by excessive extracellular matrix (ECM) deposition and impaired scar remodeling.

25 Jun 2026

MIMETAS publishes breakthrough study on 3D blood-brain barrier model with unidirectional flow

Scientists at MIMETAS have published a new study describing a scalable, self-assembling human blood-brain barrier (BBB) model that combines physiological relevance with high-throughput capability.

5 Mar 2026

Weight-loss drugs may reduce heart damage after heart attack

Weight-loss (GLP-1 mimicking) drugs may help prevent further tissue damage following a heart attack, significantly reducing the risk of further life-threatening complications that affect up to half of all patients, according to a new study led by the University of Bristol and University College London.

2 Mar 2026

AI turns routine pathology slides into powerful maps of the tumor immune landscape

A large study shows that routine H&E pathology slides contain rich spatial proteomic signals that can be decoded by AI to model the tumor immune microenvironment at population scale. By generating virtual multiplex immunofluorescence images, GigaTIME enables pan-cancer discovery of immune patterns linked to invasion stage, survival, and genomic alterations.

10 Dec 2025

Fortress, filter, and gatekeeper: New insights into how the blood-brain barrier safeguards the brain

Researchers provide a comprehensive overview of the blood-brain barrier (BBB), detailing its cellular architecture, transport mechanisms, and role in protecting the brain from toxins. The paper highlights how BBB dysfunction contributes to neurological diseases and explores emerging technologies to overcome drug delivery challenges.

21 Oct 2025

State-of-the-art microchips help understand how sepsis and neurodegenerative diseases damage the brain

In lieu of animal experiments, researchers from the University of Rochester are using state-of-the-art microchips with human tissue to better understand how the brain operates under healthy conditions and is damaged through neurodegenerative diseases or conditions like sepsis.

7 Oct 2025

Stanford scientists grow vascularized heart and liver organoids

For over a decade, scientists have been growing organoids - small clusters of cells that mimic a particular organ - to serve as miniature biological models.

6 Jun 2025

Cellular bridges aid axon growth after spinal cord damage

Capitalizing on the flexibility of tiny cells inside the body's smallest blood vessels may be a powerful spinal cord repair strategy, new research suggests.

21 Apr 2025

Innovative 3D blood-brain barrier model enhances understanding of neuroinflammation

A 3D model accurately mimicking the Blood-Brain Barrier (BBB) in a laboratory environment has been successfully developed by research teams led by Professor Jinah Jang from the Departments of Mechanical Engineering, Life Sciences, IT Convergence Engineering, and the Graduate School of Convergence at POSTECH, and Professor Sun Ha Paek from the Department of Neurosurgery at Seoul National University Hospital.

3 Feb 2025

Spatial aging clocks reveal how T cells and neural stem cells shape brain aging

Researchers developed spatial aging clocks to map brain cell aging, revealing how T cells accelerate aging and NSCs rejuvenate neighboring cells, offering new insights into brain health and interventions.

22 Dec 2024

Urine transcriptomics: A new frontier for non-invasive genitourinary disease detection

Researchers explore the potential diagnostic utility of transcriptomic and metabolic signals in the genitourinary system.

29 Oct 2024

Calcium channel blockers show potential to restore cerebral blood flow in Alzheimer's disease

Targeting calcium channels in pericytes may improve blood flow in Alzheimer's disease, addressing early vascular dysfunction linked to cognitive deficits.

23 Sep 2024

Study uncovers roles of certain brain cells in Alzheimer's plaque formation

A study in Nature Neuroscience found that both neurons and oligodendrocytes contribute to amyloid-β plaque burden in Alzheimer's disease, highlighting new therapeutic targets.

7 Aug 2024

High-resolution brain maps reveal vascular blueprint for healthy aging

Healthy blood vessels matter for more than just heart health. Vascular well-being is critical for brain health and potentially in addressing age-related cognitive decline and neurodegenerative disorders, like Alzheimer's disease, according to new study led by Penn State researchers. The findings point to an understudied but possible key role the brain's vascular network - or energy infrastructure - plays in the onset of neurodegenerative disease.

31 Jul 2024

Researchers uncover molecular signatures of blood-brain barrier dysfunction in Alzheimer's disease

The blood-brain barrier - a network of blood vessels and tissues that nurtures and protects the brain from harmful substances circulating in the blood - is disrupted in Alzheimer's disease.

26 Jun 2024

Novel "Tissue-in-a-CUBE" model mimics blood-brain barrier for drug testing

A research team at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan has succeeded in establishing a model of the blood-brain barrier using modularized tissue derived from human cells.

28 Feb 2024

Discovery of bicarbonate-sensing receptor offers therapeutic insights into ischemic stroke treatment

Researchers have identified this receptor in brain mural cells that regulates reperfusion injury.

27 Feb 2024

Ludwig scientists deconstruct the blood supply of brain metastases

A Ludwig Cancer Research study has generated a granular portrait of how the cellular and molecular components of the blood vessels that feed brain metastases of melanoma and lung and breast cancers differ from those of healthy brain tissue, illuminating how they help shape the internal environment of tumors to support cancer growth and immune evasion.

19 Jan 2024