Prion Disease News and Research

RSS

New gene-editing treatment extends lifespan in mice with prion disease

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition.

15 Jan 2025

Metagenomic sequencing improves detection of rare pathogens in CNS infections

New research shows that metagenomic next-generation sequencing (mNGS) over seven years increased pathogen detection in challenging CNS infections, identifying rare and unexpected microbes often missed by standard testing.

13 Nov 2024

AI model revolutionizes dementia diagnosis with high accuracy across multiple data sources

Researchers developed an AI model using multimodal data to accurately diagnose different types of dementia, enhancing early and personalized treatment.

8 Jul 2024

CHARMs: A new hope for prion disease therapy

Drug development is typically slow: the pipeline from basic research discoveries that provide the basis for a new drug to clinical trials to production of a widely available medicine can take decades.

27 Jun 2024

Curcumin nanoparticles show promise in treating neurodegenerative diseases

Review demonstrates curcumin's neuroprotective effects in neurodegenerative diseases, enhancing its potential through innovative nanoparticle formulations. This advancement could significantly improve treatments for diseases like Parkinson's, Alzheimer's, and Multiple Sclerosis.

6 Jun 2024

Study confirms strong barrier preventing chronic wasting disease transmission to humans

A new study of prion diseases, using a human cerebral organoid model, suggests there is a substantial species barrier preventing transmission of chronic wasting disease (CWD) from cervids - deer, elk and moose - to people.

17 May 2024

Boosting mitochondrial health can reverse protein clumping in aging and Alzheimer's

It has long been known that a hallmark of Alzheimer's disease, and most other neurodegenerative diseases, is the clumping together of insoluble protein aggregates in the brain.

16 May 2024

Novel gene-delivery vehicle shows promise for treating brain disorders

In an important step toward more effective gene therapies for brain diseases, researchers from the Broad Institute of MIT and Harvard have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver a disease-relevant gene to the brain in mice expressing the human protein.

16 May 2024

Repurposing human-approved drugs for prion disease treatment

Prions are the abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal cellular proteins.

16 May 2024

Possibility of wildlife-to-human crossover heightens concern about chronic wasting disease

Each fall, millions of hunters across North America make their way into forests and grasslands to kill deer. Over the winter, people chow down on the venison steaks, sausage, and burgers made from the animals.

2 Feb 2024

The Parkinson's Pandemic: from the importance of early diagnosis to digital solutions

News Medical spoke to Michele Hu, Consultant Neurologist at Oxford University Hospitals and Professor of Clinical Neuroscience at the Nuffield Department of Clinical Neurosciences, University of Oxford, about prodromal Parkinson's and what the future looks like for this neurological disease.

11 Apr 2023

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Researchers presented eight hallmarks of neurodegenerative diseases (NDDs), their in vivo biomarkers, and interactions to help categorize NDDs and specify patients within a specific NDD.

21 Feb 2023

Could trained scent-detection dogs be used for chronic wasting disease surveillance?

A recent study published in Prion investigated whether trained scent-detection dogs could be used for chronic wasting disease (CWD) surveillance.

13 Feb 2023

Novel prion strain causes chronic wasting disease in a Finland moose

...

19 Jan 2023

Brain changes can be studied in very early stages of neurodegenerative diseases

Many changes take place in the brain long before symptoms appear. This has been shown in mice in two studies of prion diseases in which the brain gradually deteriorates.

10 Oct 2022

NPDPSC at Case Western Reserve University to receive CDC funding for better understanding of prion diseases

The National Prion Disease Pathology Surveillance Center at Case Western Reserve University will receive up to $20 million in funding as part of a grant renewal from the Centers for Disease Control and Prevention (CDC) to better understand how and why prion diseases––degenerative brain conditions found in both humans and animals - develop and spread.

20 Sep 2022

Researchers uncover the structure of protein fibrils linked to hereditary form of human prion disease

In a new study, researchers from the Case Western Reserve University School of Medicine have identified the structure of protein fibrils linked to a hereditary form of human prion disease.

12 Sep 2022

Prion imaging could lead to better understanding of what causes fatal neurological disorders

Prion diseases are incurable, deadly neurological disorders that can affect both humans and animals–including Creutzfeldt-Jakob Disease (CJD) in people, Bovine Spongiform Encephalopathy (also known as Mad Cow Disease) and Chronic Wasting Disease found in deer.

13 Jul 2022

New technologies for early clinical diagnosis of human prion diseases

Early and accurate diagnosis of human prion diseases is a long-standing difficulty. Currently, the definitive diagnosis of human prion diseases relies on pathognomonic histological features or PrPSc detection of patients' brain tissue biopsy or autopsy samples, which is not feasible in most cases.

11 Jan 2022

New study shines light on how brain cells die in prion diseases

Prion diseases, such as Creutzfeldt-Jakob Disease (CJD), are fast-moving, fatal dementia syndromes associated with the formation of aggregates of the prion protein, PrP.

22 Dec 2021

Prion Disease News and Research

New gene-editing treatment extends lifespan in mice with prion disease

Metagenomic sequencing improves detection of rare pathogens in CNS infections

AI model revolutionizes dementia diagnosis with high accuracy across multiple data sources

CHARMs: A new hope for prion disease therapy

Curcumin nanoparticles show promise in treating neurodegenerative diseases

Study confirms strong barrier preventing chronic wasting disease transmission to humans

Boosting mitochondrial health can reverse protein clumping in aging and Alzheimer's

Novel gene-delivery vehicle shows promise for treating brain disorders

Repurposing human-approved drugs for prion disease treatment

Possibility of wildlife-to-human crossover heightens concern about chronic wasting disease

The Parkinson's Pandemic: from the importance of early diagnosis to digital solutions

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Could trained scent-detection dogs be used for chronic wasting disease surveillance?

Novel prion strain causes chronic wasting disease in a Finland moose

Brain changes can be studied in very early stages of neurodegenerative diseases

NPDPSC at Case Western Reserve University to receive CDC funding for better understanding of prion diseases

Researchers uncover the structure of protein fibrils linked to hereditary form of human prion disease

Prion imaging could lead to better understanding of what causes fatal neurological disorders

New technologies for early clinical diagnosis of human prion diseases

New study shines light on how brain cells die in prion diseases

Microbiology eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Latest News