Tranexamic Acid News and Research

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Common drug shows promise in preventing post-surgical liver failure

A multi-center study, co-led by researchers at Mayo Clinic and Michigan State University, found that patients who received tranexamic acid during liver surgery were three times less likely to develop post-hepatectomy liver failure than patients who received a placebo.

25 Jun 2026

Tranexamic acid reduces surgical transfusions without raising clot risks

A landmark clinical trial published in the prestigious New England Journal of Medicine found that tranexamic acid reduced transfusions across major surgeries without increasing the risk of dangerous blood clots.

10 Jun 2026

Tranexamic acid modestly reduces bleeding after cesarean delivery in women

Giving tranexamic acid to women with placenta praevia (when the placenta covers the cervical opening) undergoing cesarean birth leads to a significant yet modest reduction in severe bleeding after delivery with no evidence of an increase in serious adverse events, finds a trial from China published by The BMJ today.

13 May 2026

Doctors urge smarter use of universal donor blood amid shortages

As blood banks across the U.S. report dangerously low supplies of O-negative blood (red blood cells) - commonly called the "universal donor" - anesthesiologists are calling for increased donation and changes in how hospitals use the "universal donor" blood type, according to a new Innovation in Practice article published online in Anesthesiology Open, an official journal of the American Society of Anesthesiologists (ASA).

19 Mar 2026

Highlighting the global "care gap" in life-threatening injuries

A new international study published in The Lancet eClinicalMedicine has mapped global blood transfusion practices for life-threatening abdominal injuries, highlighting significant variation in care worldwide and opportunities for health systems to learn from one another.

4 Mar 2026

Plastic waste transformed into building blocks for cancer drugs

A groundbreaking discovery led by the University of St Andrews has found a way to turn ordinary household plastic waste into the building block for anti-cancer drugs.

19 Dec 2025

TXA reduces the need for blood transfusion in patients undergoing high-risk non-cardiac surgery

When hospitals were randomly assigned to treat patients undergoing higher-risk non-cardiac surgery with tranexamic acid (TXA) or a placebo, patients who received TXA needed significantly fewer blood transfusions and saw no increase in potentially life-threatening blood clots (thrombosis) after 90 days of follow-up, according to research presented at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition.

9 Dec 2025

New trial to test extended tranexamic acid use for faster ACL surgery recovery

A breakthrough could be coming in the way young people recover from surgery to reconstruct the anterior cruciate ligament (ACL) in the knee, a common sports injury.

21 Nov 2025

Advances in diagnosis and management of chronic subdural hematoma

Chronic subdural hematoma (CSDH) is one of the most common neurosurgical conditions, particularly among the elderly, with an annual incidence ranging from 1.7 to 20.6 per 100,000 people.

18 Nov 2025

Healthy Beginnings, Hopeful Futures: A Conversation with WHO’s Dr. Allotey

Dr. Pascale Allotey advocates for comprehensive maternal health policies, stressing the importance of women's voices in shaping effective healthcare solutions.

7 Apr 2025

HSS research highlights faster recovery methods after knee surgery

At this year's American Academy of Orthopedic Surgeons (AAOS) annual meeting, investigators at Hospital for Special Surgery (HSS) presented several significant studies, with three focused on new ways to help patients recover faster after total knee arthroplasty (TKA), also known as knee replacement surgery.

11 Mar 2025

Study: Iron infusions superior to blood transfusions for surgical patients with anemia

In a rigorous medical records study covering tens of thousands of patients, Johns Hopkins Medicine researchers conclude that some patients with preoperative anemia have better outcomes if they get iron infusions before surgery rather than standard red blood cell transfusions.

25 Jul 2024

Berotralstat: A promising oral treatment for hereditary angioedema with normal C1-inhibitor

BioCryst Pharmaceuticals, Inc. today announced new real-world evidence showing that patients with hereditary angioedema (HAE) who have normal C1-inhibitor (HAE-nC1-INH) level and function had a reduction in monthly attack rates after starting oral, once-daily berotralstat.

8 Jun 2024

DEPOSITION trial evaluates the use of topical tranexamic acid during heart surgery

Administering tranexamic acid (TxA), a drug used to reduce bleeding during heart surgery, topically rather than intravenously did not meet its primary endpoint of reducing seizures and was stopped early due to an increased risk of bleeding events, according to research presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

WHO releases first roadmap to combat postpartum hemorrhage worldwide

WHO today released its first roadmap to tackle postpartum hemorrhage (PPH) – defined as excessive bleeding after childbirth - which affects millions of women annually and is the world's leading cause of maternal deaths.

27 Mar 2024

Machine learning identifies trauma patients benefiting from tranexamic acid treatment

Researchers from Osaka University use machine learning to identify patients more likely to survive traumatic injury if treated with tranexamic acid.

26 Mar 2024

Chitosan tamponades: A breakthrough in treating postpartum hemorrhage

Researchers highlight chitosan-covered tamponades as a promising, accessible treatment for postpartum hemorrhage, a major cause of maternal mortality, especially where advanced medical interventions are unavailable. This method, safe and effective, offers a crucial option in emergency situations, as detailed in their study, including application guidelines and a demonstration video.

23 Nov 2023

Pitt launches trial to test interventions for life-threatening bleeding in injured children

The No. 1 cause of death in children is trauma. There are an estimated 2,000 pediatric deaths from traumatic bleeding in the U.S. each year that are preventable with optimal care, yet there have been no large-scale clinical trials to guide the best way to resuscitate children with life-threatening bleeding from traumatic injury.

21 Sep 2023

Bilateral total knee arthroplasty may increase risk of complications

Patients undergoing bilateral total knee arthroplasty (TKA) are at an increased risk of several types of complications, as compared with matched patients undergoing unilateral TKA, reports a study in The Journal of Bone & Joint Surgery.

7 Jul 2023

Tranexamic acid use linked to decreased incidence of heterotopic ossification after elbow trauma surgery

For patients undergoing surgery for elbow trauma, treatment with the hemostatic drug tranexamic acid (TXA) is associated with a decreased incidence of heterotopic ossification (HO) – a common complication of abnormal bone formation, reports a study in The Journal of Bone & Joint Surgery.

22 Jun 2023