Angiotensin News and Research

RSS

Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.

AI VIVO seeks pharma, biotech collaboration partners to advance drug candidates for COVID-19

AI VIVO has announced that it is seeking pharma and biotech collaboration partners to progress therapeutic candidates for COVID-19.

11 May 2020

No evidence COVID-19 is spread by fecal-oral transmission

A new study published on the preprint server medRxiv* in May 2020 shows that in patients who test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pharyngeal and fecal samples, the virus persists longer in the fecal samples than in the pharyngeal samples. However, fecal-oral transmission does not appear to occur.

10 May 2020

Study shows COVID-19 vulnerability is highly dependent on host genetic architecture

A new US study available on the preprint server medRxiv reveals certain genetic variations that are associated with infection susceptibility and diverse clinical presentation of coronavirus disease (COVID-19) – including asymptomatic cases and severe forms of the disease in younger patients.

10 May 2020

ACE inhibitors should not be discontinued over fears about COVID-19, say researchers

Researchers in Europe have found no evidence to support previous reports that the use of drugs that target the renin-angiotensin-aldosterone system (RAAS) increases susceptibility to coronavirus disease 2019 (COVID-19). The research is published in the European Heart Journal.

10 May 2020

Vitamin D could improve outcomes in COVID-19

A new study published on the preprint server medRxiv* in May 2020 shows that vitamin D could have a beneficial effect on the course of illness for COVID-19 patients.

7 May 2020

Study discovers inhibition of SARS-CoV-2 entry priming protein by approved drug

The COVID-19 pandemic caused by the severe acute respiratory syndrome -coronavirus 2 (SARS-CoV-2) has spread to most of the world, causing millions of cases and hundreds of thousands of deaths. A new study published on the preprint server bioRxiv* shows that a protease inhibitor drug already approved by the Food and Drug Administration (FDA) could inhibit viral entry.

6 May 2020

Low CD8 and NK cell counts in the lung linked to high SARS-CoV-2 ACE2 receptor levels

A new study published on the preprint server bioRxiv in April 2020 reports that low levels of specific immune cells, namely, CD8 T cells and NK cells, are linked to higher expression of the ACE2 molecule, which acts as a receptor for the CoV.

6 May 2020

Is ACEI, ARB use linked to testing positive for COVID-19?

A new study published in the prestigious journal JAMA Cardiology in May 2020 reports that there is no association between the use of ACEIs/ARBs and testing positive for COVID-19. This supports current medical advice to continue using these drugs as indicated irrespective of the ongoing pandemic but indicates the need for more research to rule out any additional risk of severe illness due to these agents.

6 May 2020

COVID-19 infection risk and outcomes explained by the cell receptor genetic variability

Genetic variants in the angiotensin‐converting enzyme 2 (ACE2) receptor, utilized by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) for cell entry, are predicted to either encourage or inhibit interaction with viral proteins and subsequently contribute to genetic risk in coronavirus disease (COVID-19). This is the key finding of a new study available on the preprint server bioRxiv*.

5 May 2020

Russian scientists create humanized mice to test drugs and vaccines for COVID-19

Following the recent Coronavirus outbreak, almost three million people have been infected worldwide, whereas the death toll has already passed the 200,000 mark, according to official reports.

5 May 2020

Loss of smell may be related to neuroinvasive propensity of SARS-CoV-2

The novel coronavirus has rapidly infected millions over the world in over 187 countries and territories, causing hundreds of thousands of deaths. One of the often-neglected and under-reported symptoms of the virus is the loss of the sense of smell or anosmia. Now, a new study out of Germany published on the preprint server medRxiv in April 2020 provides a quantified estimate of the magnitude of anosmia as a symptom of the coronavirus.

4 May 2020

SARS-CoV-2 receptor ‘mimic' could prevent COVID-19

Researchers from Italy have developed an exciting new peptide drug that could potentially prevent the coronavirus from infecting people’s cells. The paper, published on the preprint server bioRxiv* in April 2020, describes a small molecule that can bind to and block the attachment site on the virus spike protein, preventing its entry into the host cell.

4 May 2020

High blood pressure drugs found to be safe for COVID-19 patients

Despite concerns expressed by some experts, common high blood pressure drugs did not increase the risk of contracting COVID-19 - or of developing severe disease - in a study of 12,594 patients.

3 May 2020

AHA awards grants to 12 teams for fast-tracked heart and brain health research related to COVID-19

Less than a month after issuing a rapid response call for scientific research proposals for fast-tracked studies of the effects of COVID-19 on the body's cardiovascular and cerebrovascular systems, the American Heart Association has awarded $1.2 million in grants to teams at 12 institutions across the U.S. to begin this unprecedented work.

2 May 2020

New clinical trial to assess whether hypertension drug may reduce COVID-19 severity

Researchers at University of California San Diego School of Medicine have launched a clinical trial to investigate whether a drug approved for treating high blood pressure, heart failure and diabetic kidney disease might also reduce the severity of COVID-19 infections, lowering rates for intensive care unit admissions, the use of mechanical ventilators and all-cause mortality.

30 Apr 2020

New database catalogs peptides that may halt SARS-CoV-2 cell infection

In the quest for a highly specific and tailored treatment strategy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a recent publication available on the preprint server bioRxiv describes a repository of designed peptides that interfere with the early stages of viral invasion process.

30 Apr 2020

Fear of coronavirus propels some smokers to quit

In 40 years of smoking, Katie Kennedy has tried four times to quit but always went back to cigarettes. Today, she is summoning a new mental image when a craving comes on: rows of COVID-19 patients hooked to ventilators.

30 Apr 2020

Radboudumc researchers find essential mechanism in the disease process of COVID-19

Researchers at the Radboud University Medical Center seem to have found an essential mechanism in the disease process of COVID-19, which has so far been overlooked.

29 Apr 2020

ACE inhibitors appear to be safe and beneficial for COVID-19, say researchers

Researchers in India have conducted a meta-analysis investigating the effects of using angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) on outcomes among patients with COVID-19.

29 Apr 2020

Tobacco use may explain why more men die of coronavirus than women in Spain

Whether or not you are a smoker could condition how the coronavirus affects you. At least that is what numerous researchers are saying, insisting that tobacco use is to blame for the weakened cardiovascular systems which are at greatest risk from COVID-19.

29 Apr 2020

Angiotensin News and Research

Further Reading

AI VIVO seeks pharma, biotech collaboration partners to advance drug candidates for COVID-19

No evidence COVID-19 is spread by fecal-oral transmission

Study shows COVID-19 vulnerability is highly dependent on host genetic architecture

ACE inhibitors should not be discontinued over fears about COVID-19, say researchers

Vitamin D could improve outcomes in COVID-19

Study discovers inhibition of SARS-CoV-2 entry priming protein by approved drug

Low CD8 and NK cell counts in the lung linked to high SARS-CoV-2 ACE2 receptor levels

Is ACEI, ARB use linked to testing positive for COVID-19?

COVID-19 infection risk and outcomes explained by the cell receptor genetic variability

Russian scientists create humanized mice to test drugs and vaccines for COVID-19

Loss of smell may be related to neuroinvasive propensity of SARS-CoV-2

SARS-CoV-2 receptor ‘mimic' could prevent COVID-19

High blood pressure drugs found to be safe for COVID-19 patients

AHA awards grants to 12 teams for fast-tracked heart and brain health research related to COVID-19

New clinical trial to assess whether hypertension drug may reduce COVID-19 severity

New database catalogs peptides that may halt SARS-CoV-2 cell infection

Fear of coronavirus propels some smokers to quit

Radboudumc researchers find essential mechanism in the disease process of COVID-19

ACE inhibitors appear to be safe and beneficial for COVID-19, say researchers

Tobacco use may explain why more men die of coronavirus than women in Spain

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News