Antibody Drug Conjugate News and Research

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ADC histogram analysis can predict tumor proliferation, survival in immunocompetent patients with PCNSL

The cover for issue 45 of Oncotarget features Figure 3, "Representative images of whole tumor volume segmentation of the co-registered T1 post-contrast sequence and apparent diffusion coefficient (ADC) map, yielding the corresponding ADC histogram distribution utilized for data analysis," recently published in "Diffusion-weighted MR imaging histogram analysis in HIV positive and negative patients with primary central nervous system lymphoma as a predictor of outcome and tumor proliferation" by Khan, et al.

12 Jan 2021

Why is COVID-19 more severe among adults than children?

Researchers in Switzerland and Australia have reviewed some of the mechanisms proposed regarding why coronavirus disease 2019 (COVID-19) is generally less severe among children than among adults.

8 Dec 2020

Novel antibody-drug conjugate shows 29% response rate in rare blood cancer

Early study data shows a 29% overall response rate, the favorable safety profile in blastic plasmacytoid dendritic cell neoplasm (BPDCN)

8 Dec 2020

Researchers evaluate safety of novel therapy for patients with non-Hodgkin lymphoma

Roswell Park Comprehensive Cancer Center's Francisco J. Hernandez-Ilizaliturri, MD, along with a team of researchers from other institutions, has been investigating a novel therapy for patients with relapsed or refractory B-cell non-Hodgkin lymphoma.

7 Dec 2020

CEAT project for improving ovarian cancer diagnosis, treatment shows promise

Porvair Sciences reports, due to promising results, it has agreed with its collaborative partners to make additional investment in the CEAT project which aims to dramatically improve the diagnosis and treatment of ovarian cancer.

From Porvair Sciences Limited 16 Nov 2020

Ovarian cancer project shows promise

Porvair Sciences reports, due to promising results, it has agreed with its collaborative partners to make additional investment in the CEAT project** which aims to dramatically improve the diagnosis and treatment of ovarian cancer.

From Chromatrap® - Porvair Sciences Ltd 13 Nov 2020

Researchers develop novel chemo-immunotherapy agent to treat pancreatic tumors

Pancreatic cancer is highly lethal: according to the National Cancer Institute, only about 10 percent of patients remain alive five years after diagnosis.

6 Nov 2020

Researchers identify a potential target for small cell lung cancer

The cover for issue 39 of Oncotarget features Figure 4, "Apoptosis assay of NRXN1-targeted ADC at IC50 dose calculated by growth inhibition curves," by Yotsumoto, et al. which reported that the authors identified transmembrane proteins overexpressed specifically in SCLC with little or no expression in normal tissues and decided to focus on the cell adhesion molecule neurexin-1.

1 Oct 2020

New material identifies cancer cells and mounts a surprising attack

Many people across the globe are working hard to get the better of cancer; however cancer is always working too. Cancer cells can become resistant to the methods that have been adopted to kill them, so identifying drugs that act in different ways is part of the push to outsmart this ubiquitous disease

25 Sep 2020

New MRI technique to improve tumor diagnosis

Early diagnosis of cancer is one of the highest-priority problem for the healthcare system, because it is critical for overall treatment success and saving patients' lives. DWI may be used to detect a malignancy in various tissues and organs.

1 Jun 2020

Novel and fully automated technique can speed up detection of stroke

Human emotion system laboratory team at the University of Turku and Turku PET Centre, Finland, introduces a fully automated method for acute ischemic lesion segmentation on brain MRIs and shows how artificial intelligence can reduce the work load of radiologists.

30 Mar 2020

One in five childhood deaths in England and Wales still due to infection

A new study published in the journal Archives of Diseases of Childhood in March 2020 reveals that despite a drop to less than half, compared to 25 years ago, infection is still a cause of significant mortality among children. The most common cause of infection-related deaths in this age group are respiratory infections.

24 Mar 2020

Sleep problems as an infant may cause behavioural problems later on

Researchers from the University of Birmingham have found that infants that have sleep problems may have emotional and behavioral issues as they grow into toddlers. Their study titled, “Parent-reported early sleep problems and internalizing, externalizing, and dysregulation symptoms in toddlers”, was published in the latest issue of the BMJ Paediatrics Open.

10 Mar 2020

Researchers evaluate effectiveness of medication assisted therapy for opioid use disorder

Rebecca Sutter, Assistant Professor, School of Nursing, College of Health and Human Services, and Allison Evans Cuellar, Professor, Health Administration and Policy, CHHS, are implementing and evaluating the effectiveness of a Mobile Medication Assisted Therapy Program in the Prince William Health District that will expand capacity for opioid use disorder support and services.

9 Feb 2020

New antibody-drug conjugate shows promising activity in salivary gland tumors

The antibody-drug conjugate ado-trastuzumab emtansine (T-DM1) has promising activity in HER2 amplified salivary gland tumors, according to data published in the Annals of Oncology.

7 Jan 2020

FDA approves new drug to treat adults with advanced urothelial or bladder cancer

The U.S. Food & Drug Administration granted accelerated approval to the drug enfortumab vedotin (EV) to treat adult patients with advanced urothelial or bladder cancer.

19 Dec 2019

New combination therapy can lead to durable responses in patients with multiple myeloma

An experimental, off-the-shelf immunotherapy that combines a targeted antibody and chemotherapy can lead to potentially durable responses in multiple myeloma patients whose disease has relapsed or is resistant to other standard therapies.

17 Dec 2019

One Nucleus reveals finalists of annual BioNewsRound Award

One Nucleus reveals the finalists of its annual BioNewsRound Award, recognizing life science companies that have announced exciting developments for patients and the sector. The finalists will present at Genesis 2019 where the winner will be announced.

29 Nov 2019

Lung inflammation in a case of a 16-year-old linked to vaping

The Centre for Disease Control and Prevention (CDC) has warned earlier last month about the possible risk of lung inflammation from the exposure to the fluid in e-cigarettes. Now a case of a 16-year-old boy was reported with life threatening lung inflammation leading to respiratory failure.

12 Nov 2019

Investigators use the power of computation to build better targeted drug therapy

Antibody drug conjugates (ADCs) -- cancer drugs that are designed to target and destroy cancerous tissue while leaving healthy cells intact -- represent a long sought-after advancement in cancer therapy.

8 Nov 2019