Sickle Cell Anemia News and Research

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Sickle cell anemia is a serious disease in which the body makes sickle-shaped red blood cells. “Sickle-shaped” means that the red blood cells are shaped like a "C." Normal red blood cells are disc-shaped and look like doughnuts without holes in the center. They move easily through your blood vessels. Red blood cells contain the protein hemoglobin. This iron-rich protein gives blood its red color and carries oxygen from the lungs to the rest of the body. Sickle cells contain abnormal hemoglobin that causes the cells to have a sickle shape. Sickle-shaped cells don’t move easily through your blood vessels. They’re stiff and sticky and tend to form clumps and get stuck in the blood vessels. (Other cells also may play a role in this clumping process.) The clumps of sickle cells block blood flow in the blood vessels that lead to the limbs and organs. Blocked blood vessels can cause pain, serious infections, and organ damage.
Metabolism can impact host's susceptibility to develop malaria

Metabolism can impact host's susceptibility to develop malaria

Expert highlights CRISPR’s applications, limitations, and ethical concerns

Expert highlights CRISPR’s applications, limitations, and ethical concerns

New genomic research partnership promises to redefine and transform cancer treatment

New genomic research partnership promises to redefine and transform cancer treatment

'Organic gene therapy' could be effective treatment approach for serious blood disorders

'Organic gene therapy' could be effective treatment approach for serious blood disorders

MSU researcher developing new miniature models to study heart disease and sickle cell anemia

MSU researcher developing new miniature models to study heart disease and sickle cell anemia

Americord introduces Digital Birth Plan to help expectant parents make informed choices

Americord introduces Digital Birth Plan to help expectant parents make informed choices

Researchers discover innovative way to produce hematopoietic stem cells

Researchers discover innovative way to produce hematopoietic stem cells

Innovative gene therapy allows complete remission of clinical signs of sickle cell disease

Innovative gene therapy allows complete remission of clinical signs of sickle cell disease

Upstate opens new public cord blood bank in New York

Upstate opens new public cord blood bank in New York

Yale researchers use new gene editing technique to correct mutations that cause thalassemia

Yale researchers use new gene editing technique to correct mutations that cause thalassemia

Genome engineering-based methods pave way for new treatment of patients with sickle cell disease

Genome engineering-based methods pave way for new treatment of patients with sickle cell disease

New study finds no evidence of benefit from genetic disposition of eczema

New study finds no evidence of benefit from genetic disposition of eczema

New mobile health app may help manage hydroxyurea treatments in sickle cell patients

New mobile health app may help manage hydroxyurea treatments in sickle cell patients

Scientists link malfunctioning molecular pathways to specific heart abnormalities in SCA

Scientists link malfunctioning molecular pathways to specific heart abnormalities in SCA

New computer model shows how spleen filters misshapen red blood cells

New computer model shows how spleen filters misshapen red blood cells

Scientists develop non-toxic transplantation procedure using antibodies to target blood stem cells in mice

Scientists develop non-toxic transplantation procedure using antibodies to target blood stem cells in mice

Minihepcidins may potentially treat serious genetic blood diseases in children, adults

Minihepcidins may potentially treat serious genetic blood diseases in children, adults

Inhalable form of Ambrisentan drug could offer faster-acting treatment option for pulmonary edema

Inhalable form of Ambrisentan drug could offer faster-acting treatment option for pulmonary edema

Three Case Western faculty members receive funding to develop new diagnostic technologies

Three Case Western faculty members receive funding to develop new diagnostic technologies

Acupuncture may be safe, effective treatment for chronic pain in pediatric patients

Acupuncture may be safe, effective treatment for chronic pain in pediatric patients