Ulcerative Colitis News and Research

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Ulcerative colitis is a common inflammatory disease of the colon characterized by inflammation and ulceration of the large bowel and rectum. The condition impairs the ability of the large bowel to absorb water which results in diarrhea, the main symptom of the condition.

Ulcerative colitis is a relapsing and remitting condition, meaning symptoms can die down for long periods but then flare-up from time to time. These flare-ups can be sudden and severe. During a period of relapse, symptoms may include bloody diarrhea, abdominal pain and a sudden urge to defecate. Other symptoms include wind, loss of appetite, weight loss, fever and fatigue.

Currently, there is no cure for the condition apart from surgery. However, certain treatments such as corticosteroids or immunosuppressants may be used to ease symptoms by reducing inflammation. Surgery for severe ulcerative colitis that does not respond to treatment involves completely removing the large bowel and re-routing the small bowel so that waste can still be expelled. This procedure is called a colectomy.

In the UK, the incidence of ulcerative colitis is around 1 in 500 and the condition is equally common among males and females. Symptoms can develop at any age, but onset usually occurs between 15 and 30 years of age.
Biomedical scientist receives $1.83 million NIH grant for inflammatory bowel disease research

Biomedical scientist receives $1.83 million NIH grant for inflammatory bowel disease research

Researchers win $1.4 million federal grant to study new treatment approaches for intestinal inflammation

Researchers win $1.4 million federal grant to study new treatment approaches for intestinal inflammation

Mango intake exerts beneficial effects in progression and severity of IBD

Mango intake exerts beneficial effects in progression and severity of IBD

Scientists uncover link between backup pathogen-fighting system and mutations in Crohn's patients

Scientists uncover link between backup pathogen-fighting system and mutations in Crohn's patients

UA researchers seek to better understand NHE8 protein’s role in GI disorders, colon cancer

UA researchers seek to better understand NHE8 protein’s role in GI disorders, colon cancer

Genetic test to predict IBD severity in children

Genetic test to predict IBD severity in children

Living in rural households lowers person's risk of developing IBD, study finds

Living in rural households lowers person's risk of developing IBD, study finds

Titanium dioxide nanoparticles can intensify inflammatory reaction in patients with colitis

Titanium dioxide nanoparticles can intensify inflammatory reaction in patients with colitis

Adherence to prescribed medication improves health and increases cost savings

Adherence to prescribed medication improves health and increases cost savings

Human colon organoids fill gap in effectively modeling common GI diseases

Human colon organoids fill gap in effectively modeling common GI diseases

UAB researchers demonstrate persistence of donor microbes in recipients after fecal transplant

UAB researchers demonstrate persistence of donor microbes in recipients after fecal transplant

Children suffering from IBD not meeting daily recommended intake of calcium and vitamin D

Children suffering from IBD not meeting daily recommended intake of calcium and vitamin D

New study finds dramatic reorganization of the gut caused by weight loss surgery

New study finds dramatic reorganization of the gut caused by weight loss surgery

Cedars-Sinai researchers analyze social media posts to find medication concerns of IBD patients

Cedars-Sinai researchers analyze social media posts to find medication concerns of IBD patients

Microbes can manipulate molecular machinery of host cells to influence health

Microbes can manipulate molecular machinery of host cells to influence health

Scientists identify gene linked to incurable bowel disorders

Scientists identify gene linked to incurable bowel disorders

Composition, function of intestinal bacteria could predict response to biologic drugs in IBD patients

Composition, function of intestinal bacteria could predict response to biologic drugs in IBD patients

New research could lead to earlier diagnosis and better management of inflammatory bowel disease

New research could lead to earlier diagnosis and better management of inflammatory bowel disease

Leti's New Deal project could revolutionize IBD therapies for great benefit of patients in the European Union

Leti's New Deal project could revolutionize IBD therapies for great benefit of patients in the European Union

Researchers discover that microRNA can prevent excessive intestinal inflammation

Researchers discover that microRNA can prevent excessive intestinal inflammation