Biochemistry

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Characterizing and Isolating (Bio)macromolecular Structures using MALS

In this interview, Albena Lederer, Head of the Polymer Separation Group at the Leibniz Institute for Polymer Research, talks to News-Medical Life Sciences about the techniques and methods used to understand and analyze polymers.

From Waters | Wyatt Technology 26 Jun 2019

Using Light Scattering to Characterize Protein-Nucleic Acid Interactions

Harnessing the interactions between DNA, RNA, and proteins holds much promise for detecting biomarkers, diagnosing disease, and improving cancer-targeting therapeutics. Quantifying these interactions is essential for understanding and controlling their biomolecular mechanisms.

From Waters | Wyatt Technology 26 Jun 2019

Atomwise and Enamine launch 10 billion compound virtual drug screening initiative

Atomwise, Inc. today announced the launch of a 10 billion compound AI-powered virtual drug screening initiative, the 10-to-the-10 program, in collaboration with Enamine Ltd., the world’s largest chemical supplier.

25 Jun 2019

Engineered cell evolution may provide a path to reduce chemotherapy resistance

A significant problem when treating cancer patients remains drug resistance, which often causes chemotherapy treatments to ultimately fail.

25 Jun 2019

Study sheds light on rhodopsin dynamics in the retina

Photoreceptor cells in our eyes can adjust to both weak and strong light levels, but we still don't know exactly how they do it.

24 Jun 2019

Researchers unlock mystery of immunosuppressive drug's biosynthesis

Mycophenolic acid (MPA), discovered in 1893, was the first natural antibiotic to be isolated and crystallized in human history.

22 Jun 2019

New DNA Microscopy Technique Offers Novel Insight into Genomic Information in Cells

Scientists are now able to see inside cells to a genomic level with a newly invented imaging technique called DNA microscopy. Using DNA “bar codes”, DNA microscopy allows scientists to locate a molecule’s position in a sample without using any kind of optics, meaning genomic information can be collected in large amounts.

21 Jun 2019

McMaster researchers map toxic protein associated with Alzheimer's

A team of researchers from McMaster University has mapped at atomic resolution a toxic protein linked to Alzheimer's disease, allowing them to better understand what is happening deep within the brain during the earliest stages of the disease.

20 Jun 2019

Creating a physical and genetic map of Cannabis sativa

Scientists have developed a physical and genetic map of Cannabis sativa to facilitate further investigation into the genetic and molecular mechanisms exhibited by this plant.

19 Jun 2019

Metabolic engineering of cannabinoids – are we there yet?

There has recently been a surge in research into the biosynthetic pathways of cannabinoids and the potential for commercialized metabolic engineering.

19 Jun 2019

Researchers develop technique to track proteins on the surfaces of endoplasmic reticulum in cells

Researchers from Kanazawa University on the development of a technique to closely track a specific protein on the surfaces of endoplasmic reticulum (ER) in cells. Their findings are published in Bioorganic and Medicinal Chemistry.

17 Jun 2019

Researchers demystify the smell of dark chocolate

Chocolate is one of the most-consumed treats around the world, and the smell alone is usually enough to evoke strong cravings from even the most disciplined eaters.

17 Jun 2019

Scientists delay aging using protein found in young mice

Scientists have shown that a protein which is abundant in the blood of young mice can delay the aging process of older mice.

17 Jun 2019

Mutant bacterial receptor could help identify therapeutic compounds that inhibit quorum sensing

Researchers have developed a new mutant version of a receptor used by a bacterial pathogen for a chemical communication process called quorum sensing, according to a study published June 13 in the open-access journal PLOS Pathogens by Bonnie Bassler of Princeton University, and colleagues.

From PLOS ONE 14 Jun 2019

Research suggests new way to improve the efficacy of arthritis drug

Attaching a removable lock to an arthritis drug can make it safer and more effective, according to a new study publishing June 13 in the open-access journal PLOS Biology led by Wen-Wei Lin of Kaohsiung Medical University, Taiwan.

From PLOS ONE 14 Jun 2019

Ultra-Small Microelectrode Biosensors for Brain Injury Analysis

An interview with Stéphane Marinesco, discussing the development of ultra-small microelectrode biosensors for the analysis of traumatic brain injuries.

From Pittcon 14 Jun 2019

Super-Resolution Raman Imaging with Plasmonic Substrates

Renee Frontiera discusses the development of a super-resolution Raman microscope that could one day supersede fluorescence-based super-resolution microscopes.

From Pittcon 14 Jun 2019

Researchers challenge prior theories about how materials travel within E.coli cell

The flow of traffic through our nation's highways and byways is meticulously mapped and studied, but less is known about how materials in cells travel.

13 Jun 2019

New technology harnesses bacterial jumping genes for precise DNA integration

A new discovery by researchers at Columbia University Vagelos College of Physicians and Surgeons could fix one of the major shortcomings of current gene-editing tools, including CRISPR, and offer a powerful new approach for genetic engineering and gene therapy.

13 Jun 2019

Roche Diagnostics launches first in vitro diagnostic ROS1 immunohistochemistry assay

Roche Diagnostics today announced the launch of the VENTANA ROS1 Antibody, the first and only in vitro diagnostic ROS1 immunohistochemistry assay. The test detects the presence of ROS1 protein in tissue, and may be useful in identifying ROS1-positive lung cancer cases.

From Roche Sequencing and Life Science 10 Jun 2019