Biochemistry

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Antibiotic blocks the integration of building blocks into the cell wall of pathogens

One of the last arrows in the quiver in the fight against dangerous bacteria is the reserve antibiotic daptomycin.

21 Mar 2020

CARB-X awards $2.86M to develop novel oral antibiotic to treat drug-resistant gonorrhea

Up to $2.86M has been awarded to a research team including Penn State scientists to develop a new oral antibiotic to treat multidrug-resistant gonorrhea, a sexually transmitted disease caused by bacteria that have developed resistance to all but one existing antibiotic.

20 Mar 2020

Researchers produce fat busting proteins in the lab

Triglycerides, those fats that seem to be the bane of any diet, remain a mystery for many researchers. Plenty of them are in Big Macs, deep pan pizza and the like, but some are a necessity to fuel the body for daily activities.

19 Mar 2020

Cryo-electron microscopy helps visualize ball-and-chain inactivation of ion channels

Ion channels, which allow potassium and sodium ions to flow in and out of cells, are crucial in neuronal 'firing' in the central nervous system and for brain and heart function.

19 Mar 2020

EHD2 protein plays a key role in fat metabolism

Many foods - whether it's the mozzarella on your favorite pizza, the olive oil in salad dressing or hollandaise sauce during asparagus season - contain lots of fat. The fatty acids in these foods are among the essential nutrients that people need to survive.

17 Mar 2020

New type of artificial binding proteins for blocking sugar structures on cell surfaces

The laboratory directed by Arne Skerra, Professor of Biological Chemistry, has its focus on designing artificial binding proteins for therapeutic applications.

17 Mar 2020

Scientists engineer silkworms to produce different variants of adhesion molecules

Silkworms are useful for more than just making strong and absorbent strings of silky thread for the textiles industry.

16 Mar 2020

Two brain-signaling molecules control anemonefish fathering and aggression

Two brain-signaling molecules control how anemonefish dads care for their young and respond to nest intruders, researchers report in a new study.

16 Mar 2020

Researchers show possibility of blending two incompatible components in one nanofiber

Russian researchers from the Federal Research Clinical Center of Physical-Chemical Medicine, the Moscow Institute of Physics and Technology, and Lomonosov Moscow State University showed the possibility of blending two incompatible components -- a protein and a polymer -- in one electrospun fiber.

16 Mar 2020

Scientists find new way to amplify miRNA in live tumor cells for bioimaging

A good indicator of dysregulation in live cells is a change in their RNA expression. MicroRNA (miRNA), a special type of RNA, is considered a biomarker for carcinogenic cells.

16 Mar 2020

Max Planck researchers identify mechanistic basis of antigen receptor gene assembly

Adaptive immunity is a powerful defense mechanism in vertebrates. A finely tuned interplay of different cell types provides a pathogen-specific immune response to eliminate for example bacteria and viruses.

13 Mar 2020

UC Riverside biochemist and Atomwise form new joint venture

Over the past few years, biochemist John Jefferson Perry at the University of California, Riverside, has collaborated on a number of projects with Atomwise Inc., a company that uses artificial intelligence, or AI, for drug discovery.

13 Mar 2020

Single-drug therapy can attack several cellular targets using different modes of action

Clinicians combat the drug resistances of some cancer types by using a combination of different drugs. To make this approach more effective, chemists have designed a chemical conjugate that can simultaneously attack several cellular targets using different modes of action.

13 Mar 2020

Researchers uncover possible pitfalls of common hormone analysis in animal hair

Similar to humans, wild animals' reaction to disturbance is accompanied by releasing hormones, such as cortisol.

12 Mar 2020

New nano strategy for 'trapping and zapping' antibiotic resistant genes

It's not enough to take antibiotic-resistant bacteria out of wastewater to eliminate the risks they pose to society. The bits they leave behind have to be destroyed as well.

12 Mar 2020

Innovative technique can create new type of biocompatible microparticles

Biomedical engineers at Duke University have devised a method for making small particles that are safe for living tissues that will allow them to create new shapes attractive for drug delivery, diagnostics and tissue engineering.

12 Mar 2020

New biochemical mechanism in cells is crucial component of anti-aging program

Aging is an inevitable part of life, yet some species are aging very differently than others, even than very similar ones.

11 Mar 2020

Characterization of novel L-fucose metabolism pathway in anaerobic bacteria

The genetic context in bacterial genomes and screening for potential substrates can help identify the biochemical functions of bacterial enzymes.

11 Mar 2020

Study shows JNK protein as a stress sensor in synapses

New study from Eleanor Coffey's lab at Turku Bioscience Centre in Finland identifies that the JNK protein triggers nerve cells to withdraw their synapses when stressed.

11 Mar 2020

Researchers visualize first structure of key enzyme that helps make triglycerides

The first structure of a lipin enzyme, which carries out an important step in the production of triglycerides, the main reservoir for long-term energy storage, will help scientists to better understand how lipins regulate the production of triglycerides.

11 Mar 2020

Biochemistry

Antibiotic blocks the integration of building blocks into the cell wall of pathogens

CARB-X awards $2.86M to develop novel oral antibiotic to treat drug-resistant gonorrhea

Researchers produce fat busting proteins in the lab

Cryo-electron microscopy helps visualize ball-and-chain inactivation of ion channels

EHD2 protein plays a key role in fat metabolism

New type of artificial binding proteins for blocking sugar structures on cell surfaces

Scientists engineer silkworms to produce different variants of adhesion molecules

Two brain-signaling molecules control anemonefish fathering and aggression

Researchers show possibility of blending two incompatible components in one nanofiber

Scientists find new way to amplify miRNA in live tumor cells for bioimaging

Max Planck researchers identify mechanistic basis of antigen receptor gene assembly

UC Riverside biochemist and Atomwise form new joint venture

Single-drug therapy can attack several cellular targets using different modes of action

Researchers uncover possible pitfalls of common hormone analysis in animal hair

New nano strategy for 'trapping and zapping' antibiotic resistant genes

Innovative technique can create new type of biocompatible microparticles

New biochemical mechanism in cells is crucial component of anti-aging program

Characterization of novel L-fucose metabolism pathway in anaerobic bacteria

Study shows JNK protein as a stress sensor in synapses

Researchers visualize first structure of key enzyme that helps make triglycerides

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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