Biochemistry

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New tool shows potential to predict developmental toxicity in humans with high accuracy

Recently published results from an evaluation of 1,065 chemical and drug substances using the devTOX quickPredict (devTOXqP) screening platform developed by Stemina Biomarker Discovery, Inc. demonstrated the platform's ability to predict developmental toxicity in humans with high accuracy using a cell-based test.

3 Mar 2020

WFIRM scientists develop miniature organ model to test drug toxicity

Scientists at the Wake Forest Institute for Regenerative Medicinehave developed the world's most sophisticated laboratory model of the human body, creating a system of miniaturized organs that can be used to detect harmful and adverse effects of drugs before they are prescribed to patients.

2 Mar 2020

Researchers develop multi-organ-on-a-chip for drug toxicity screening

Researchers in the US have developed a new multi-organ-on-a-chip to test how new drugs affect the human body's vital organs.

2 Mar 2020

ORNL story tips on antidote chasing, traffic control and automatic modeling

In the most comprehensive, structure-based approach to date, a team of scientists may have discovered a new family of antidotes for certain poisons that can mitigate their effects more efficiently compared with existing remedies.

2 Mar 2020

Researchers explore the role of SLC25A32 in cancer cell proliferation

Oncotarget Volume 11 Issue 8 reported that while it is known that cancer cells require one-carbon and FAD-dependent mitochondrial metabolism to sustain cell proliferation, the role of SLC25A32 in cancer cell growth remains unexplored.

28 Feb 2020

Research shows how physical cues drive cell migration, cancer metastasis, and treatment

Cancer cells are a product of their environment. The surrounding cells, extracellular matrix, and other features influence disease progression and spread of cancer cells to other parts of the body.

28 Feb 2020

New discovery may be useful for developing novel cancer treatments

Researchers from the University of Copenhagen have discovered that our cells replicate their DNA much more loosely than previously thought.

28 Feb 2020

First evidence of rare amino acid in the fruit of durian tree

Researchers at the Leibniz-Institute for Food Systems Biology at the Technical University of Munich have confirmed the presence of the rare amino acid ethionine in a plant - or more precisely, in the fruit of the durian tree.

28 Feb 2020

Researchers measure how often pet cats eat outside of their food bowls

A study that set out to measure how much wildlife domestic cats eat to supplement the food they are given by their owners was unsuccessful due to an unexpectedly high variability in cat food ingredients.

28 Feb 2020

Collaborative project aims to study red blood cells under physiological flow conditions

Red blood cells (erythrocytes) are the pack animals of the human circulatory system. They transport oxygen to the places in the body where it's needed: to the cells that make up our muscles and organs.

27 Feb 2020

Researchers elucidate structure and function of enzyme that builds complex sugar trees

Researchers have used cryo-electron microscopy to elucidate for the first time the structure and function of a very small enzyme embedded in cell membranes.

27 Feb 2020

New method to detect phenols in smoked food samples using vitamin B4

Today, phenols are used to produce medicines, paints, and inexpensive furniture made of chipboard or MDF panels and also to process food. Some of them are capable of imparting a pleasant smoky aroma to food, so they are often added to sausage or fish.

26 Feb 2020

New clue behind chronic diseases and food spoilage discovered

Scientists at the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have made a surprising discovery that could help explain our risk for developing chronic diseases or cancers as we get older, and how our food decomposes over time.

26 Feb 2020

New discovery will change our understanding of bile production

Forget what you know about bile because that's about to change, thanks to a new discovery made by Michigan State University and published in the current issue of Nature.

26 Feb 2020

McMaster researchers identify antibacterial compound made by cannabis plants

McMaster University researchers have identified an antibacterial compound made by cannabis plants that may serve as a lead for new drug development.

26 Feb 2020

Aggressive cancers set up a structural framework to keep the immune system at bay

Aggressive colorectal cancers set up an interactive network of checkpoints to keep the immune system at bay, scientists report.

26 Feb 2020

Understanding the arms race between bacteria and viruses

University of Otago researchers have contributed to an international study which helps improve the understanding of bacteria and viruses.

25 Feb 2020

Novel combination of techniques used to compare the effects of two pesticides

University of Saskatchewan researchers have used a novel combination of techniques to compare the effects of two families of pesticides used in agriculture, and found that at low dosages the newer pesticide is less toxic than a currently used neonicotinoid one.

25 Feb 2020

Researchers uncover how cancer cells override environmental cues to consume energy

Using human lung cancer cells, UT Southwestern researchers have uncovered how cells in general modulate their energy consumption based on their surroundings and, furthermore, how cancer cells override those cues to maximize energy use.

24 Feb 2020

Clemson researchers discover protein function in parasites which afflict millions with diseases

In the quest to develop more effective treatments for parasitic diseases like African sleeping sickness, Chagas disease and Leishmaniasis, scientists look for weaknesses in the organisms' molecular machinery. These weaknesses can then be targeted with drug therapies designed to kill the parasites.

24 Feb 2020