Biochemistry

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Scientists discover how bacterial evolution of antibiotic arsenals is providing new drug blueprints

Scientists from Trinity College Dublin have discovered that two very different species of bacteria have evolved distinct, powerful antibiotic arsenals for use in the war against their bacterial neighbors.

9 Jan 2020

New screening platform helped scientists to discover drug-like compounds

A sophisticated new screening platform developed by scientists at Scripps Research has enabled them to discover a set of drug-like compounds, including an ingredient found in sore throat lozenges, that may powerfully protect brain cells from dangerous stresses found in Alzheimer's and other neurodegenerative diseases.

9 Jan 2020

Researchers report first structural model for key enzyme associated with inherited eye diseases

Researchers at the University of New Hampshire have reported the first structural model for a key enzyme, and its activating protein, that can play a role in some genetically inherited eye diseases like retinitis pigmentosa and night blindness.

8 Jan 2020

Persistent TB infection of macrophages puts the brakes on immune engines, study shows

Scientists from Trinity College Dublin have discovered both how TB puts the brakes on our immune engines and how we can kick-start those engines back into gear - providing hope that improved treatment options could soon be on the horizon.

8 Jan 2020

Research adds definitive evidence about how the body's earliest immune cells are formed

One day the advance could lead to a patient's own skin cells being used to produce new cells for cancer immunotherapy or to test autoimmune disease interventions.

8 Jan 2020

Researchers study new immunogenic properties of already existing anti-cancer drugs

The world scientific community is waging a difficult and prolonged war on cancer. New research in the field of immunogenic cell death can extend the area of drugs application and ensure patients' protection from relapse after therapy.

3 Jan 2020

Structure of most lethal toxin produced by C. difficile bacteria identified

Researchers from the University of Maryland School of Medicine and their colleagues have identified the structure of the most lethal toxin produced by certain strains of Clostridium difficile bacteria, a potentially deadly infection associated with the use of antibiotics. The

2 Jan 2020

Measuring glycans in samples of antibodies

When Lorna De Leoz invited laboratories to participate in her glycomics study, she hoped for 20 responses. Instead, she was deluged by emails from around the world.

2 Jan 2020

Researchers move closer to identifying leukemic stem cells

Acute myeloid leukemia is the most common type of leukemia in adults. It is characterized by the pathological expansion of immature cells (myeloblasts) that invade the bone marrow and expand into the blood, affecting the production of the rest of the healthy cells.

2 Jan 2020

Studying Alzheimer’s and Parkinson’s Disease using Pre-Formed Fibrils

Ariel Louwrier discusses the development of pre-formed tau and alpha-synuclein fibrils for research into Alzheimer's and Parkinson's disease.

From StressMarq Biosciences Inc. 2 Jan 2020

Advancement in reconstitution of the blood system from human pluripotent stem cells

The reconstitution of the blood system in humans holds great therapeutic potential to treat many disorders, like blood cancers, sickle-cell anemia and others.

31 Dec 2019

Research reveals how the brain balances pleasure and pain

As our brains take in information about the world and use it to steer our actions, two key principles guide our choices: seek pleasure and avoid pain.

31 Dec 2019

Scientists identify molecules capable of inhibiting DNA methylation, effectively killing malaria parasites

Parasites in the genus Plasmodium, which cause malaria, are transmitted to humans through bites from infected mosquitoes.

31 Dec 2019

Inputs to the motor cortex can guide dexterous movements in mice

In a sleepy haze, reaching out and grabbing the coffee cup in front of you seems to happen on autopilot. But your caffeine-deprived brain is working hard.

26 Dec 2019

NIH awards $1.2 million grant for studying biomolecular interactions to inform better drug design

Biomolecules -- carbohydrates, proteins, nucleic acids, and lipids -- form the foundation of life and are responsible for carrying out every process that occurs in our bodies.

23 Dec 2019

Developing less aggressive cancer drugs that enable the immune system to recognize tumors

Doctors treat tumors mainly through surgery, radiotherapy, and chemotherapy. Over the next four years, a new project of Bielefeld University and 14 European partners will be studying targeted cancer treatments.

21 Dec 2019

Scientists identify molecular mechanisms that protect cells against mechanical stress

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have identified the molecular mechanisms that allow our cells to adapt to, protect themselves against, and survive mechanical stress.

20 Dec 2019

Jefferson researcher probes kidney cancer's genes for interactions with p53 pathway

p53 is the most famous cancer gene, not least because it's involved in causing over 50% of all cancers. When a cell loses its p53 gene -- when the gene becomes mutated -- it unleashes many processes that lead to the uncontrolled cell growth and refusal to die, which are hallmarks of cancer growth.

20 Dec 2019

Observing 3D Microscopic Images using Virtual Reality

Dr. Christopher Zugates discusses a revolutionary way of analyzing complex 3D images in protein biology… through virtual reality!

From arivis AG 19 Dec 2019

Researchers identify first gene in mice specific to memory retrieval

Can't remember something? Try waiting until later in the day. Researchers identified a gene in mice that seems to influence memory recall at different times of day and tracked how it causes mice to be more forgetful just before they normally wake up.

18 Dec 2019

Biochemistry

Scientists discover how bacterial evolution of antibiotic arsenals is providing new drug blueprints

New screening platform helped scientists to discover drug-like compounds

Researchers report first structural model for key enzyme associated with inherited eye diseases

Persistent TB infection of macrophages puts the brakes on immune engines, study shows

Research adds definitive evidence about how the body's earliest immune cells are formed

Researchers study new immunogenic properties of already existing anti-cancer drugs

Structure of most lethal toxin produced by C. difficile bacteria identified

Measuring glycans in samples of antibodies

Researchers move closer to identifying leukemic stem cells

Studying Alzheimer’s and Parkinson’s Disease using Pre-Formed Fibrils

Advancement in reconstitution of the blood system from human pluripotent stem cells

Research reveals how the brain balances pleasure and pain

Scientists identify molecules capable of inhibiting DNA methylation, effectively killing malaria parasites

Inputs to the motor cortex can guide dexterous movements in mice

NIH awards $1.2 million grant for studying biomolecular interactions to inform better drug design

Developing less aggressive cancer drugs that enable the immune system to recognize tumors

Scientists identify molecular mechanisms that protect cells against mechanical stress

Jefferson researcher probes kidney cancer's genes for interactions with p53 pathway

Observing 3D Microscopic Images using Virtual Reality

Researchers identify first gene in mice specific to memory retrieval

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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