Cell Biology

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Research highlights the importance of meninges for brain development and pathology

A new study, led by researchers at the University of Gothenburg, have generated the first comprehensive transcriptional atlas of neonatal mouse meningeal leukocytes, under normal conditions and after perinatal brain injury.

31 Aug 2021

New compounds offer a two-for-one punch to fight estrogen-sensitive breast cancer

A set of compounds developed by scientists at Scripps Research in Florida target estrogen-sensitive breast cancer cells in new ways, potentially creating better options for patients with treatment-resistant cancers.

31 Aug 2021

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Oncotarget published "Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase" which reported that it is necessary to investigate actionable genes and candidate drugs using a sophisticated knowledgebase and characterize BTCs immunologically for evaluating the actionability of molecular and immune therapies.

31 Aug 2021

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Aging-US published "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence" which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy tissues.

31 Aug 2021

Study highlights the robustness of miRNA modulation during aging process

Aging-US published "miRNAs generated from Meg3-Mirg locus are downregulated during aging" which reported that Aging determines a multilevel functional decline and increases the risk for cardiovascular pathologies.

28 Aug 2021

Mystery of roe deer embryonic diapause revealed

Everyone is familiar with the roe deer, either from crossword puzzles or from real-life encounters during a jog or a hike in the forest: majestic creatures with elegant big black eyes.

28 Aug 2021

Research analyzes the role of RNA tags in Alzheimer’s disease

Understanding the role of tau protein in Alzheimer's disease (AD) has led to new ways to diagnose it as well as the creation of medicines now in clinical trials to treat it.

28 Aug 2021

Researchers convert human stem cells into beta cells using small molecules

The human body can be genetically inclined to attack its own cells, destroying the beta cells in the pancreas that make insulin, which helps convert sugar into energy.

27 Aug 2021

UZH and Airbus aim to grow three-dimensional organ-like tissues in microgravity

UZH Space Hub and Airbus Defence and Space are sending an experiment into space on the next resupply flight to the International Space Station (ISS) with the aim of advancing the industrial production of human tissue in microgravity.

26 Aug 2021

Restoring DAXX protein levels may prevent misfolding of rogue proteins known to drive Alzheimer's

For the first time, Penn Medicine researchers showed how restoring levels of the protein DAXX and a large group of similar proteins prevents the misfolding of the rogue proteins known to drive Alzheimer's and other neurodegenerative diseases, as well as certain mutations that contribute to cancers.

26 Aug 2021

Brain organoids provide a valuable model to study autism

Variations in the 16p11.2 region of the genome are associated with autism spectrum disorder. While people with genetic deletions in this region have larger heads (macrocephaly) and people with genetic duplications have smaller heads (microcephaly), both variation types affect brain development and function.

26 Aug 2021

Stiffening of heart’s blood vessels associated with lack of enzyme that fosters cell ‘chatter’

In a study in mice, Johns Hopkins Medicine researchers have found that the smooth muscle cells lining the walls of blood vessels can lose their elasticity and lead to vascular stiffening, a condition that can precede heart disease and stroke.

26 Aug 2021

Studies offer insight into how the human body develops and acquires mutations throughout life

New insights into how the human body develops from one cell into trillions, and the genetic mutations that cells pick up along the way, have been generated by two studies from scientists at the Wellcome Sanger Institute, the University of Cambridge and their collaborators.

26 Aug 2021

Study unravels widespread tumor suppression mechanism that halts cancer metastasis

According to a study by The Wistar Institute, the tumor suppressor Parkin, whose levels are reduced in different cancer types, causes acute metabolic and oxidative stress, suppresses mitochondrial trafficking, and blocks tumor cell movement, reducing primary and metastatic tumor growth.

26 Aug 2021

Brain refreshing takes place during the dream-active phase of sleep

Scientists have long wondered why almost all animals sleep, despite the disadvantages to survival of being unconscious.

25 Aug 2021

Penn study shows how certain proteins have evolved to suppress cheating chromosomes

Eggs and sperm are special cells for many reasons, but one of the characteristics that sets them apart is that, unlike other human cells, which have two copies of 23 chromosomes, one from the mother and one from the father, these sex cells, or gametes, have only one.

25 Aug 2021

Cell Biology

Research highlights the importance of meninges for brain development and pathology

New compounds offer a two-for-one punch to fight estrogen-sensitive breast cancer

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Study highlights the robustness of miRNA modulation during aging process

Mystery of roe deer embryonic diapause revealed

Research analyzes the role of RNA tags in Alzheimer’s disease

Researchers convert human stem cells into beta cells using small molecules

UZH and Airbus aim to grow three-dimensional organ-like tissues in microgravity

Restoring DAXX protein levels may prevent misfolding of rogue proteins known to drive Alzheimer's

Brain organoids provide a valuable model to study autism

Stiffening of heart’s blood vessels associated with lack of enzyme that fosters cell ‘chatter’

Studies offer insight into how the human body develops and acquires mutations throughout life

Study unravels widespread tumor suppression mechanism that halts cancer metastasis

Brain refreshing takes place during the dream-active phase of sleep

Penn study shows how certain proteins have evolved to suppress cheating chromosomes

Study provides new insight into the mosquito immune system and disease transmission

New discovery may lead to more effective treatments for osteoarthritis, other cartilage diseases

Intestinal microorganisms help regulate anti-tumor immune responses to radiation therapy, study finds

Study uncovers how breast cancer cells use cholesterol to overcome stress-induced death mechanism

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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