Cell Biology

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Tiny antibody component shows high potency in SARS-CoV-2 animal models

University of Pittsburgh School of Medicine scientists have isolated the smallest biological molecule to date that completely and specifically neutralizes the SARS-CoV-2 virus, which is the cause of COVID-19.

14 Sep 2020

New bone-on-a-chip device could revolutionize pharmaceutical pre-clinical testing

A new technology that could be used to test new treatments for human organs and bone tissue - all whilst reducing the need for animal research - has been developed by engineers at the University of Sheffield.

14 Sep 2020

TRESK regulates the brain's circadian clock to differentiate behavior between day and night

Research from the University of Kent has found that TRESK, a calcium regulated two-pore potassium channel, regulates the brain's central circadian clock to differentiate behavior between day and night.

14 Sep 2020

Cell signaling research rings warning bells over an emerging cancer drug target

Researchers at the Babraham Institute have used their understanding of cellular signalling to highlight a pitfall in an emerging treatment for cancer and inflammation.

14 Sep 2020

Researchers identify the missing link in the production of nitric oxide

Some microorganisms, the so-called methanotrophs, make a living by oxidizing methane (CH4) to carbon dioxide (CO2). Ammonia (NH3) is structurally very similar to methane, thus methanotrophs also co-metabolize ammonia and produce nitrite.

14 Sep 2020

Tobacco plant promotes tissue adhesion and can maintain grafts between different species

Grafting is a horticultural technique that joins plants together by means of tissue regeneration, combining desirable characteristics of both plants. Generally, grafts have been thought to be compatible only between the same or closely related species.

14 Sep 2020

Exploring sex differences in gene expression

Males and females share the vast majority of their genomes. Only a sprinkling of genes, located on the so-called X and Y sex chromosomes, differ between the sexes. Nevertheless, the activities of our genes--their expression in cells and tissues--generate profound distinctions between males and females.

12 Sep 2020

Study demonstrates new method to synthesize gold nanoparticles in cancer cells

Dipanjan Pan, professor of chemical, biochemical, and environmental engineering at UMBC, and collaborators published a seminal study in Nature Communications that demonstrates for the first time a method of biosynthesizing plasmonic gold nanoparticles within cancer cells, without the need for conventional bench-top lab methods.

12 Sep 2020

Antiviral effects of honeysuckle decoction affected in SIDT1poly population

Previously, Chen-Yu Zhang's group have identified SID1 transmembrane family member 1 (SIDT1) as a critical membrane protein mediating dietary miRNAs absorption, which is abolished in SIDT1 deficient mice.

11 Sep 2020

A new approach to study the role of Neandertal DNA during development

Protocols that allow the transformation of human induced pluripotent stem cell (iPSC) lines into organoids have changed the way scientists can study developmental processes and enable them to decipher the interplay between genes and tissue formation, particularly for organs where primary tissue is not available.

11 Sep 2020

Intestinal grafts grown using stem cells could lead to personalized transplants for children

Pioneering scientists at the Francis Crick Institute, Great Ormond Street Hospital and UCL Great Ormond Street Institute of Child Health have grown human intestinal grafts using stem cells from patient tissue that could one day lead to personalized transplants for children with intestinal failure, according to a study published in Nature Medicine today (Monday 7th September).

10 Sep 2020

Fungi can develop drug resistance without genetic changes

The management of fungal infections in plants and humans could be transformed by a breakthrough in understanding how fungi develop resistance to drugs.

9 Sep 2020

Allergic immune response against bacteria is not pathological but protective

Allergy is one of the most common diseases in Europe, it is estimated that more than 150 million Europeans suffer from recurring allergies and by 2025 this could have increased to half of the entire European population.

9 Sep 2020

Common diabetes drug controls aspects of inflammation in mice

The diabetes drug metformin--derived from a lilac plant that's been used medicinally for more than a thousand years--has been prescribed to hundreds of millions of people worldwide as the frontline treatment for type 2 diabetes.

9 Sep 2020

Scientists shed new light on gene regulatory pathways activated by stress hormone

Scientists have long known that chronic stress experienced early in life, or even chronic prenatal exposure to maternal stress hormones in the womb, can shorten lifespan and contribute to age-related chronic diseases like arthritis, asthma, cancer, cardiovascular disease, diabetes and even mental illness later in life -- long after the source of stress has been removed.

9 Sep 2020

Computer model can replicate the unique firing-rate dependent behavior of Purkinje neurons

Research conducted by the Computational Neuroscience Unit at the Okinawa Institute of Science and Technology Graduate University has shown for the first time that a computer model can replicate and explain a unique property displayed by a crucial brain cell.

8 Sep 2020

Cell Biology

Tiny antibody component shows high potency in SARS-CoV-2 animal models

New bone-on-a-chip device could revolutionize pharmaceutical pre-clinical testing

TRESK regulates the brain's circadian clock to differentiate behavior between day and night

Cell signaling research rings warning bells over an emerging cancer drug target

Researchers identify the missing link in the production of nitric oxide

Tobacco plant promotes tissue adhesion and can maintain grafts between different species

Exploring sex differences in gene expression

Study demonstrates new method to synthesize gold nanoparticles in cancer cells

Antiviral effects of honeysuckle decoction affected in SIDT1poly population

A new approach to study the role of Neandertal DNA during development

Intestinal grafts grown using stem cells could lead to personalized transplants for children

Fungi can develop drug resistance without genetic changes

Allergic immune response against bacteria is not pathological but protective

Common diabetes drug controls aspects of inflammation in mice

Scientists shed new light on gene regulatory pathways activated by stress hormone

Computer model can replicate the unique firing-rate dependent behavior of Purkinje neurons

New findings change the understanding of cholesterol’s effects on cellular membranes

Acne drug could be a potential treatment for dilated cardiomyopathy

Lack of oxygen can trigger tumor metastases

Moving towards a new age of personalized, cell-based interceptive medicine for Europe

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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