Cell Biology

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Two discoveries can lead to a new wave of more-complex organoid development

In back-to-back reports published Aug. 27, 2020, in Nature Communications, a team of scientists from Cincinnati Children's and Japan report discoveries that will be vital to a new wave of more-complex organoid development.

27 Aug 2020

New sequencing approach can detect rare mutation in large number of cells

A sequencing approach can home in on a rare mutation within a large number of cells, revealing implications for CRISPR genome editing and early cancer detection.

27 Aug 2020

Improved type of PROTAC enhances intracellular accumulation and protein knockdown

Cancer therapies sometimes involve drugs that mediate the breakdown of specific intracellular proteins that participate in cancer formation and proliferation.

27 Aug 2020

Largely ignored 'housekeeping' gene plays a role in seizures

Within cells, molecules known as transfer RNAs, or "tRNAs," play an important but unglamorous workhorse role in keeping the genetic translation process moving along from codes of DNA to functional proteins.

26 Aug 2020

Tumor hierarchy of breast cancer cells can be potential cause for drug resistance

You might have heard the old proverb, "It takes a village to raise a child."

25 Aug 2020

Advances in Virus Epigenetics

Growing evidence shows viruses exploit epigenetic processes to control their life cycles but epigentic regulation of viral infections is not fully understood.

From Chromatrap® - Porvair Sciences Ltd 25 Aug 2020

Study finds unique viral 'fingerprint' for each human gut

Each person's gut virus composition is as unique as a fingerprint, according to the first study to assemble a comprehensive database of viral populations in the human digestive system.

24 Aug 2020

New approach provides a roadmap for linking neurological and locomotor deficits

Locomotion deficits, such as lack of coordination, a shuffling gait, or loss of balance, can result from neurological conditions, specifically those that affect motor areas of the nervous system.

24 Aug 2020

Lasting nature of IBD linked to a long-lived immune cell that provokes damaging inflammation

Inflammatory bowel disease (IBD) is a group of intestinal disorders affecting an estimated six to eight million people worldwide.

24 Aug 2020

Researchers identify mechanisms leading to immune 'exhaustion' in severe viral infections

Melbourne researchers have identified mechanisms leading to the functional deterioration of the immune system in response to severe viral infections, such as HIV or COVID-19.

24 Aug 2020

Faulty RNA quality control system leads to haywire production of toxic proteins in FTLD/ALS

Researchers at Osaka University identify vicious cycle involving RNA exosome that accelerates disease progression in FTLD/ALS

24 Aug 2020

Scientists identify possible way to speed up the communication between brain regions

Selective communication among different brain regions is crucial for brain function. But the weak and sparse connectivity of the brain is a big hurdle.

21 Aug 2020

Genomic analysis reveals vulnerability of many animal species to SARS-CoV-2 infection

Humans are not the only species facing a potential threat from SARS-CoV-2, the novel coronavirus that causes COVID-19, according to a new study from the University of California, Davis.

21 Aug 2020

New bioluminescent reporter developed to track DNA double stranded break repair

A new bioluminescent reporter that tracks DNA double stranded break repair in cells has been developed by researchers from Massachusetts General Hospital and the Academia Sinica in Taiwan.

21 Aug 2020

Researchers find clues to successful immune response in the T cells of COVID-19 patients

When news about a novel coronavirus switched from a chronicle of its progress in China to headlines about a worldwide COVID-19 pandemic, Gladstone Institutes scientist Nadia Roan, PhD, was in the midst of publishing several papers on T cells and their role in HIV spread and long-lasting infections.

21 Aug 2020

Researchers develop 3D imaging technique to visualize damaged lung tissue after severe COVID-19

Physicists at the University of Göttingen, together with pathologists and lung specialists at the Medical University of Hannover, have developed a three-dimensional imaging technique that enables high resolution and three-dimensional representation of damaged lung tissue following severe Covid-19.

21 Aug 2020

Using engineered off-the-shelf therapeutic T cells to fight cancer

Personalized cancer treatments are no longer just options of the future. In the past few years, researchers have made significant progress in 'teaching' the body's immune T cells to recognize and kill specific cancer cells, and human clinical trials have shown that this approach can successfully eliminate tumors.

20 Aug 2020

Cell Biology

Two discoveries can lead to a new wave of more-complex organoid development

New sequencing approach can detect rare mutation in large number of cells

Improved type of PROTAC enhances intracellular accumulation and protein knockdown

Largely ignored 'housekeeping' gene plays a role in seizures

Tumor hierarchy of breast cancer cells can be potential cause for drug resistance

Advances in Virus Epigenetics

Study finds unique viral 'fingerprint' for each human gut

New approach provides a roadmap for linking neurological and locomotor deficits

Lasting nature of IBD linked to a long-lived immune cell that provokes damaging inflammation

Researchers identify mechanisms leading to immune 'exhaustion' in severe viral infections

Faulty RNA quality control system leads to haywire production of toxic proteins in FTLD/ALS

Scientists identify possible way to speed up the communication between brain regions

Genomic analysis reveals vulnerability of many animal species to SARS-CoV-2 infection

New bioluminescent reporter developed to track DNA double stranded break repair

Researchers find clues to successful immune response in the T cells of COVID-19 patients

Researchers develop 3D imaging technique to visualize damaged lung tissue after severe COVID-19

Using engineered off-the-shelf therapeutic T cells to fight cancer

Study evaluates the reliability of new serological assays for detecting SARS-CoV-2 antibodies

Study could help understand the evolution of nervous systems in animals and humans

Adaptions to aging may be impacted by genetic background

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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