Cell Biology

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Personalizing CAR-T cell stimulation during manufacturing can enhance its functionality

New adoptive T cell therapies - in which T cells, the immune system's natural hunters patrolling the body for foreign adversaries, are retrieved from cancer-riddled patients, super-charged and amplified outside the body, and then infused back into the same patient - are changing the prospects of cancer patients.

10 Feb 2023

Molecular switch regulates autophagy in plants

Autophagy, or "self-eating", is an essential cellular quality control mechanism that clears the cell of protein aggregates and damaged organelles. This mechanism is inactive under normal conditions and only triggered upon persistent cellular stress.

10 Feb 2023

Researchers gain new insights into the development of drug-resistant mutant lineages of cells

A deeper understanding of how tumor cells respond to treatment is vital to improving the effectiveness of therapies for diseases such as cancer.

10 Feb 2023

New method for capturing moments during protein translation

Nascent polypeptide chains or polypeptidyl-tRNAs (pep-tRNAs) occur transiently during protein synthesis. The potential to study these intermediates and better understand their role in processes like gene regulation has been greatly enhanced by the development of a process termed PETEOS—short for peptidyl-tRNA enrichment using organic extraction and silica adsorption.

10 Feb 2023

Scientists find microRNAs in human pancreatic cells that are strongly linked with type 2 diabetes

In a new large-scale genetic analysis, scientists have found a set of small RNA molecules, called microRNAs, in human pancreatic cells that are strongly associated with type 2 diabetes.

9 Feb 2023

EGFR protein plays a decisive role in the penetration of hepatitis E virus into cells

A certain surface protein is crucial to allow the hepatitis E virus to enter cells. Medication can suppress it.

9 Feb 2023

Researchers identify new mechanism that causes hereditary diseases

Researchers from Charité – Universitätsmedizin Berlin, the Max Planck Institute for Molecular Genetics (MPIMG), and the University Hospital Schleswig-Holstein (UKSH) have investigated in detail how BPTA syndrome, an extremely rare hereditary condition, arises.

9 Feb 2023

Newest vitamin B3 family member has beneficial effects on mitochondria in the human muscle

The newest vitamin B3 family member, nicotinamide riboside (NR) has been found to have beneficial effects on mitochondria in the human muscle.

8 Feb 2023

Study reveals some of the fundamental biology of p97 protein in neurodegenerative disease

The p97 protein is one of your body's best garbage disposers. It floats around in your cells looking for signals that a protein is past its shelf life and needs to be trashed.

7 Feb 2023

Study finds high levels of hydrogen peroxide in pancreatic cancer cells

Reactive oxygen species (ROS) are reputed for their involvement in carcinogenesis. Results from a study published in the journal Angewandte Chemie have now shown that the level of one such ROS,

7 Feb 2023

USC researchers identify two promising avenues for developing new ALS treatments

Each year in the U.S., 5,000 patients receive a diagnosis of ALS, an incurable neurodegenerative disease that will likely kill them within two to five years.

7 Feb 2023

Lymphatic vessels may be a previously unrecognized source of blood cells

Scientists investigating the causes of lymphoedema have made a major discovery, revealing that lymphatic vessels can produce red and white blood cells.

7 Feb 2023

Newly identified gene signature helps assess cancer risk and optimize treatment

In a paper published in PNAS, Maureen Murphy, Ph.D., Deputy Director of Wistar's Ellen and Ronald Caplan Cancer Center and Ira Brind Professor and Program Leader in the Molecular & Cellular Oncogenesis Program, and team have identified a gene signature that accurately predicts the functioning of P53 variants, important information to assessing cancer risk and optimizing choices for cancer therapeutics.

7 Feb 2023

Cancer-causing viruses use a human protein to evade the innate immune response

The viruses Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) have been linked to several cancers.

6 Feb 2023

Study reveals mechanism of a previously unexplained type of cell death

A study from researchers at The University of Texas MD Anderson Cancer Center, published today in Nature Cell Biology, details a previously unexplained type of cell death called disulfidptosis that could open the door for novel cancer therapeutic strategies.

6 Feb 2023

Cell Biology

Personalizing CAR-T cell stimulation during manufacturing can enhance its functionality

Molecular switch regulates autophagy in plants

Researchers gain new insights into the development of drug-resistant mutant lineages of cells

New method for capturing moments during protein translation

Scientists find microRNAs in human pancreatic cells that are strongly linked with type 2 diabetes

EGFR protein plays a decisive role in the penetration of hepatitis E virus into cells

Researchers identify new mechanism that causes hereditary diseases

Newest vitamin B3 family member has beneficial effects on mitochondria in the human muscle

Study reveals some of the fundamental biology of p97 protein in neurodegenerative disease

Study finds high levels of hydrogen peroxide in pancreatic cancer cells

USC researchers identify two promising avenues for developing new ALS treatments

Lymphatic vessels may be a previously unrecognized source of blood cells

Newly identified gene signature helps assess cancer risk and optimize treatment

Cancer-causing viruses use a human protein to evade the innate immune response

Study reveals mechanism of a previously unexplained type of cell death

Cryo-EM provides new insights into the structure of the centromeric region

Researchers discover how a protein deficiency can prepare the brain to minimize damage after stress

Study reveals a vulnerability of macrophages that contributes to chronic inflammatory diseases

MIT study helps shed light on why the immune system mounts a dull response to lung cancer

UT Southwestern research could lead to new ways of controlling gene regulation

The Proteoform Puzzle: Unlocking the Next Frontier

Synthetic Biology and the Pursuit of Living Diagnostics

Modular, Scalable, Intelligent: How n6 Is Rethinking NGS Library Prep

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