Cell Biology

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Researchers discover the molecule responsible for guiding T cells toward tumors

Immunotherapy, particularly CAR T-Cell treatment for cancer, is extending the lives of many patients. But sometimes the therapy randomly migrates to places it shouldn't go, tucking into the lungs or other noncancerous tissue and causing toxic side effects.

18 Apr 2023

Latest single cell technology identifies cell types related to CAD pathogenesis

A new study from the University of Eastern Finland identified 12 different cell types involved in the pathogenesis of coronary artery disease, CAD. The researchers also showed that the genetic risk factors for CAD take their effect especially via smooth vascular muscle cells, which change their phenotype as the disease progresses.

18 Apr 2023

New study aims to elucidate the role of p21 in chronic lung inflammation

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 7, entitled, "p21 facilitates chronic lung inflammation via epithelial and endothelial cells."

18 Apr 2023

Tissue-resident memory cells are key to immunity to Salmonella in mice

Salmonella infections cause about a million deaths a year worldwide, and there is an urgent need for better vaccines for both typhoid fever and non-typhoidal Salmonella disease.

18 Apr 2023

Scientists discover a protein domain that could lead to new COVID-19 treatments

Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.

18 Apr 2023

Light-activated SpyLigation can turn on proteins both inside and outside of living cells

Scientists can now use light to activate protein functions both inside and outside of living cells. The new method, called light-activated SpyLigation, can turn on proteins that are normally off to allow researchers to study and control them in more detail.

18 Apr 2023

New AI-based method for virtual staining of histopathological tissue samples

Researchers from the University of Eastern Finland, the University of Turku, and Tampere University have developed an artificial intelligence-based method for virtual staining of histopathological tissue samples as a part of the Nordic ABCAP consortium. Chemical staining has been the cornerstone of studying histopathology for more than a century and is widely applied in, for example, cancer diagnostics.

18 Apr 2023

IOB researchers identify an active multi-layer embryonic brain circuit

Using a new approach for studying live embryonic mouse brains at single-cell resolution, researchers have identified an active multi-layer circuit that forms in the cortex during an unexpectedly early stage of development. Perturbing the circuit genetically led to changes similar to those seen in the brains of people with autism. The findings are reported today in Cell by a team based at the Institute of Molecular and Clinical Ophthalmology Basel.

18 Apr 2023

Study shows how a biological clock molecule contributes to lung scarring

Abnormal sleep patterns, like those of night-shift workers, disrupt the body's natural biological clock and have been linked to lung health issues.

17 Apr 2023

Gene discovery could pave the way for a non-hormonal male contraceptive

Discovery of a gene in multiple mammalian species could pave the way for a highly effective, reversible and non-hormonal male contraceptive for humans and animals.

17 Apr 2023

Study unearths 12 different cell types involved in the pathogenesis of coronary artery disease

A new study from the University of Eastern Finland identified 12 different cell types involved in the pathogenesis of coronary artery disease, CAD.

17 Apr 2023

How SARS-CoV-2 Omicron subvariants have evolved to evade host T-cell immunity

Researchers investigate whether SARS-CoV-2 and its variants have evolved to evade CD8+ T cell-mediated immunity.

15 Apr 2023

First-ever largest atlas of post-zygotic genome mutations in healthy human tissue created

Researchers have created the largest atlas of post-zygotic genome mutations in healthy human tissue ever assembled - a scientific advancement that could unlock new avenues for diagnosing and treating genetic disease.

13 Apr 2023

B cells use mechanical force to pull antigen molecules off other cells

Most cells evolve slowly, accumulating incremental changes that better suit their environments. Immune cells, because they must adapt rapidly to counter new threats, evolve much more quickly.

13 Apr 2023

Study uncovers hallmarks to improving pancreatic cancer therapy

Scientists from the University of California, Irvine, the University of Michigan and the University of Texas MD Anderson Cancer Center have made a significant contribution to the field of pancreatic cancer research.

13 Apr 2023

Researchers show how the EBV virus exploits genomic weaknesses to cause cancer

The Epstein-Barr virus (EBV) is easily spread through bodily fluids, primarily saliva, such as kissing, shared drinks or using the same eating utensils.

13 Apr 2023

Curtin researchers identify the genetic signature of pre-malignant liver cells

Researchers at Curtin University have identified the genetic signature of pre-malignant liver cells, offering potentially significant implications for the almost 3,000 Australians diagnosed with the deadly cancer each year.

13 Apr 2023

Changes to tumor DNA can help predict cancer's next move

Knowing whether a tumor might grow or spread to other parts of a patient’s body could be key to survival – and now scientists are one step closer to unlocking the ability to predict just that.

13 Apr 2023

Research reveals molecular features of rare mtDNA mutations

A high-throughput single-cell single-mitochondrial genome sequencing technology known as iMiGseq has provided new insights into mutations of mitochondrial DNA (mtDNA) and offers a platform for assessing mtDNA editing strategies and genetic diagnosis of embryos prior to their implantation.

13 Apr 2023

New tool provides insight into the developmental history of certain immune cells

A new tool that can uncover the developmental history of certain immune cells is now freely available worldwide. The tool provides insights into the stages that immune cells go through in a healthy individual and how this can be impacted in disease.

13 Apr 2023