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Investigation of SARS-CoV-2 antibody responses in patients with aggressive hematological malignancies

Patients with hematological malignancy (PHM), also infected with COVID-19, were investigated for SARS-CoV-2 antibody responses while undergoing systemic anti-cancer therapy. While no obvious correlation is found between the serological results and the hematological diagnosis and the treatment, the immune response is similar to the severity of COVID-19 infection observed in the general population.

4 Oct 2020

Higher prevalence of SARS-CoV-2 with D614G mutation in Washington State

The study findings also indicate that the 614G viral variant is associated with higher viral load, but not with disease severity. The study is currently available on the medRxiv preprint server.

4 Oct 2020

The implications of COVID-related sexual distancing and clinical service interruption

A recent study conducted in the Atlanta area reveals that coronavirus disease 2019 (COVID-19) related sexual distancing together with clinical service interruption for sexually transmitted diseases can potentially impact the future incidence of human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). The study is currently available on the medRxiv* preprint server.

4 Oct 2020

More evidence Pangolin not intermediary in transmission of SARS-CoV-2 to humans

The team proposed a different model named the ‘circulation model’ to illustrate how SARS-CoV-2-related coronaviruses could have circulated in different species, including humans, before COVID-19 emerged.

4 Oct 2020

NPIs reduced SARS-CoV-2 transmission in South Korea

Although some studies examined how public health interventions can help contain COVID-19 outbreaks, not much information was available on public health measures against SARS-CoV-2 transmission, specifically in South Korea.

4 Oct 2020

A comprehensive clinical and genetic model for predicting severe COVID-19 risk

While determining the risk of severe COVID-19, age, and gender are usually the only considerations. A recent preprint paper published in medRxiv, discusses how researchers from Genetic Technologies Limited, Australia, used the UK Biobank data to develop a comprehensive model that can predict severe COVID-19 risk by incorporating comorbidity risk factors, demographic information, and a set of genetic markers.

4 Oct 2020

Rapid detection of SARS-CoV-2 with portable CRISPR-based mobile phone diagnostic test

A large group of researchers from the United States reported developing an amplification-free CRISPR-based mobile phone assay for direct detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from nasal swabs. Their state-of-the-art paper is currently available on the medRxiv* preprint server.

4 Oct 2020

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

In a new bioRxiv* preprint paper, researchers from the Imperial College London, King's College London, and the University of Bristol in the United Kingdom show that the furin cleavage site of SARS-CoV-2 spike glycoprotein represents a key determinant for transmission among humans, as it substantially facilitates replication in airway cells - opening the door for the development of novel therapeutics.

4 Oct 2020

Identifying cardiopulmonary processes involved in severe COVID-19

Researchers in the United States have identified cardiopulmonary processes that may partly explain why some individuals with coronavirus disease 2019 (COVID-19) develop respiratory failure.

4 Oct 2020

Modeling viral clades improves prediction of COVID-19 growth rates

A new study conducted by researchers at the University of Connecticut has revealed a correlation between the prevalence of particular clades of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the growth rate of the associated illness coronavirus disease 2019 (COVID-19).

4 Oct 2020

Shedding light on origin, transmission, spread of COVID-19 in Norfolk

Researchers in the UK have conducted a large-scale whole-genome sequencing study of clinical samples positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Norfolk area to shed light on the origins, genetic variation, transmission, and spread of the virus in the region.

4 Oct 2020

Anti-sense agents suppress SARS-CoV-2 virus

Researchers in the United States have conducted a study showing that anti-sense agents called peptide-conjugated morpholino oligomers (PPMOs) have the ability to specifically and potently suppress the growth of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

4 Oct 2020

Parkinson's disease is an independent risk factor for dying from COVID-19, study suggests

A new study of approximately 80,000 patients shows that people with Parkinson's disease (PD) have a 30% higher risk of dying from COVID-19 than people without the neurodegenerative condition.

1 Oct 2020

PATH wins grant to develop oral treatment option for soil-transmitted helminth infections

PATH announced today they received a grant from Japan's Global Health Innovative Technology Fund to develop a new oral treatment option for soil-transmitted helminth infections.

1 Oct 2020

New AGA report details effectiveness and safety of fecal microbiota transplantation

Today, the American Gastroenterological Association released the first results from the NIH-funded AGA Fecal Microbiota Transplantation National Registry, the largest real-world study on the safety and effectiveness of FMT.

1 Oct 2020

Combinational therapy with antibiotics and stem cells effectively treats bone infections

Bone infections caused by implants are difficult to treat and usually require a prolonged course of antibiotic treatment.

1 Oct 2020

New multiplexed test with a low-cost sensor may enable at-home COVID diagnosis

One feature of the COVID-19 virus that makes it so difficult to contain is that it can be easily spread to others by a person who has yet to show any signs of infection.

1 Oct 2020

Researchers develop AI algorithm to evaluate chest X-rays for COVID-19 diagnosis

A team of researchers at the University of Minnesota recently developed and validated an artificial intelligence algorithm that can evaluate chest X-rays to diagnose possible cases of COVID-19.

1 Oct 2020

Study provides in-depth analysis on VTE risk in COVID-19 patients

In a systematic review of the worldwide published data on "Venous thromboembolism (VTE) in COVID-19 patients", Cihan Ay, Stephan Nopp, and Florian Moik from the Department of Medicine I, Clinical Division of Haematology and Haemostaseology, now for the first time, provide an in-depth analysis on the risk of VTE in patients hospitalized for COVID-19.

1 Oct 2020

Biometric smartwatch data could accurately detect earliy signs of COVID-19

Certain changes in a person's heart and breathing rates could precede symptoms of COVID-19, an increasing number of studies suggests.

1 Oct 2020

Disease/Infection News

Investigation of SARS-CoV-2 antibody responses in patients with aggressive hematological malignancies

Higher prevalence of SARS-CoV-2 with D614G mutation in Washington State

The implications of COVID-related sexual distancing and clinical service interruption

More evidence Pangolin not intermediary in transmission of SARS-CoV-2 to humans

NPIs reduced SARS-CoV-2 transmission in South Korea

A comprehensive clinical and genetic model for predicting severe COVID-19 risk

Rapid detection of SARS-CoV-2 with portable CRISPR-based mobile phone diagnostic test

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

Identifying cardiopulmonary processes involved in severe COVID-19

Modeling viral clades improves prediction of COVID-19 growth rates

Shedding light on origin, transmission, spread of COVID-19 in Norfolk

Anti-sense agents suppress SARS-CoV-2 virus

Parkinson's disease is an independent risk factor for dying from COVID-19, study suggests

PATH wins grant to develop oral treatment option for soil-transmitted helminth infections

New AGA report details effectiveness and safety of fecal microbiota transplantation

Combinational therapy with antibiotics and stem cells effectively treats bone infections

New multiplexed test with a low-cost sensor may enable at-home COVID diagnosis

Researchers develop AI algorithm to evaluate chest X-rays for COVID-19 diagnosis

Study provides in-depth analysis on VTE risk in COVID-19 patients

Biometric smartwatch data could accurately detect earliy signs of COVID-19

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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