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Supervised rehabilitation program can help patients with lasting symptoms of COVID-19

Patients with lasting symptoms of COVID-19 who completed a six week, supervised rehabilitation programme demonstrated significant improvements in exercise capacity, respiratory symptoms, fatigue and cognition, according to researchers at the National Institute for Health Research Leicester Biomedical Research Centre - a partnership between Leicester's Hospitals, the University of Leicester and Loughborough University.

7 May 2021

Pfizer-BioNTech mRNA vaccine reduces both symptomatic and asymptomatic COVID-19 infection in case study

Follow-up of vaccinated and unvaccinated individuals at St. Jude Children’s Research Hospital revealed asymptomatic infection reduced by 90% and symptomatic infections reduced by up to 96% in vaccinated people compared to those not vaccinated.

7 May 2021

How did SARS-CoV-2 first evolve in humans?

In a perspective article recently published in the journal Science, Hyeryun Choe and Michael Farzan from the Scripps Research Institute, USA, have described the early-stage evolution of SARS-CoV-2 in humans. They have provided a detailed overview of how early mutations in SARS-CoV-2 spike protein facilitate its adaptation in human systems.

7 May 2021

Immunosuppression in COVID-19 promotes emergence of multiple immune escape mutants

An interesting new study describes the emergence of several such variants from a chronically immunosuppressed COVID-19 patient, who remained infected for over 170 days before clearing the virus.

7 May 2021

The ancestor of SARS-CoV-2’s Wuhan strain was circulating in late October 2019

The SARS-CoV-2 was first reported in a case from Wuhan, China, in December 2021, and subsequently became the cause of the COVID-19 pandemic that is ravaging the world today. A new study in the journal Molecular Biology and Evolution tracks its variants all over the world since the onset of the pandemic.

7 May 2021

Are infants at greater risk of COVID-19 than children?

The widely circulating SARS-CoV-2 has caused the devastating COVID-19 pandemic. The impact of this infection varies significantly with age, sparing young children for the most part, though not completely. However, a new study, released as a preprint on the medRxiv* server, shows that infants are not as resistant to the virus as children are. The researchers trace this to the expression of ACE2 to varying extents in different groups.

7 May 2021

Could antiviral surface designs help reduce SARS-CoV-2’s spread?

In an effort to improve surface decontamination methods, researchers from the Indian Institute of Technology (IIT), Bombay, looked at fabricating surfaces with virucidal properties. More specifically, these scientists investigated surface properties that could prevent the survival of viruses on these surfaces, particularly SARS-CoV-2.

7 May 2021

Heart Research UK awards grant for new project investigating long-term effects of COVID-19 on the heart

A project at Newcastle University investigating long-term inflammation of the heart following COVID-19 infection has been awarded a grant of almost £150,000 by national charity Heart Research UK.

7 May 2021

Human organoids useful for modeling COVID-19 variants of concern, finds study

A new study published on the bioRxiv* preprint server found that using human organoids could help with better characterizing the phenotype of several viral variants, including B.1.1.7. Their findings show the ribonucleic acid (RNA) shedding of the SARS-CoV-2 variant correlated with viral fitness and infectiousness.

7 May 2021

COVID-19 may impact the heart health of young, healthy adults

New research published in Experimental Physiology highlight the possible long term health impacts of COVID-19 on young, relatively healthy adults who were not hospitalized and who only had minor symptoms due to the virus.

7 May 2021

Researchers report encouraging results from experimental antiviral targeting Marburg virus

The Marburg virus, a relative of the Ebola virus, causes a serious, often-fatal hemorrhagic fever. Transmitted by the African fruit bat and by direct human-to-human contact, Marburg virus disease currently has no approved vaccine or antivirals to prevent or treat it.

7 May 2021

Increased symptomatic levels of COVID-19 may be associated with psychiatric symptoms

A significant level of symptoms of depression, anxiety and post-traumatic stress may follow COVID-19 independent of any previous psychiatric diagnoses, according to new research by Columbia University Mailman School of Public Health with colleagues at Universidade Municipal de São Caetano do Sul in Brazil.

7 May 2021

Highly efficient immune response in asymptomatic SARS-CoV-2 patients

Researchers in Singapore have investigated the role of SARS-CoV-2-specific antibodies and T-cells in asymptomatic individuals suffering from COVID-19. They found that, contrary to some initial hypotheses, asymptomatic individuals mount an adaptive immune response on par with symptomatic individuals, demonstrating that T cell response does not appear to be correlated with symptom severity.

7 May 2021

Molecular clues explain why some neurons are more susceptible than others in Alzheimer’s disease

In the brain of a person with Alzheimer's disease, neurons degenerate and die, slowly eliminating memories and cognitive skills. However, not all neurons are impacted equally.

7 May 2021

New mathematical model predicts disease spread patterns

Early on in the COVID-19 pandemic, health officials seized on contact tracing as the most effective way to anticipate the virus's migration from the initial, densely populated hot spots and try to curb its spread.

7 May 2021

SARS-CoV-2 infection prolongs viral shedding and lymphocyte loss in patients with cancer

Patients with cancer have a more challenging time with infections while undergoing treatment — placing them as high-risk for severe COVID-19 illness and death. However, how the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts with cancer therapies remains poorly understood.

7 May 2021

Global spread of COVID-19 has raised serious concern for patients with transthyretin amyloidosis

The global spread of COVID-19 has raised serious concern for patients with chronic disease. A correlation has been identified between the severity of COVID-19 and a patient's preexisting comorbidities.

7 May 2021

Bubonic plague had long-term impact on human immune genes, indicates study

Scientists examining the remains of 36 bubonic plague victims from a 16th century mass grave in Germany have found the first evidence that evolutionary adaptive processes, driven by the disease, may have conferred immunity on later generations of people from the region.

7 May 2021

A new method for producing faster and more efficient vaccines

Vaccines are currently a great source of hope for many people, as it is believed they will help to protect society against COVID-19 and pave the way back to a normal life. The current focus is clearly on coronavirus — but vaccines are also fundamental to combating other pathogens.

7 May 2021

Cryptic pocket on the surface of SARS-CoV-2 may be a promising treatment target

In a new study currently available on the bioRxiv* preprint server, a multinational group of researchers modeled an entire membrane-embedded spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and highlighted the potential of a specific mapping approach for unveiling cryptic, potentially druggable pockets on the viral surface.

7 May 2021

Disease/Infection News

Supervised rehabilitation program can help patients with lasting symptoms of COVID-19

Pfizer-BioNTech mRNA vaccine reduces both symptomatic and asymptomatic COVID-19 infection in case study

How did SARS-CoV-2 first evolve in humans?

Immunosuppression in COVID-19 promotes emergence of multiple immune escape mutants

The ancestor of SARS-CoV-2’s Wuhan strain was circulating in late October 2019

Are infants at greater risk of COVID-19 than children?

Could antiviral surface designs help reduce SARS-CoV-2’s spread?

Heart Research UK awards grant for new project investigating long-term effects of COVID-19 on the heart

Human organoids useful for modeling COVID-19 variants of concern, finds study

COVID-19 may impact the heart health of young, healthy adults

Researchers report encouraging results from experimental antiviral targeting Marburg virus

Increased symptomatic levels of COVID-19 may be associated with psychiatric symptoms

Highly efficient immune response in asymptomatic SARS-CoV-2 patients

Molecular clues explain why some neurons are more susceptible than others in Alzheimer’s disease

New mathematical model predicts disease spread patterns

SARS-CoV-2 infection prolongs viral shedding and lymphocyte loss in patients with cancer

Global spread of COVID-19 has raised serious concern for patients with transthyretin amyloidosis

Bubonic plague had long-term impact on human immune genes, indicates study

A new method for producing faster and more efficient vaccines

Cryptic pocket on the surface of SARS-CoV-2 may be a promising treatment target

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

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