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SARS-CoV-2 is activated for fusion by a broad range of proteases, finds study

A team of researchers from the University of Virginia, USA, used single-virus fusion experiments with exogenously controlled proteases to investigate the mechanism of activation directly. They found that the subcellular location of entry depends on the protease activity of the various components, and parallel pathways are possible.

6 May 2021

Transplant recipients with COVID-19 may show lower cellular and antibody immune responses

Transplant patients are typically on chronic immunosuppression, making them automatically more vulnerable to infection with SARS-CoV-2, the agent responsible for the loss of over three million lives in the current COVID-19 pandemic. A new study discusses evidence for subnormal immune responses following COVID-19 in this population.

6 May 2021

Aberrant immune features in healthy elderly and male subjects with severe COVID-19 may predate infection

A new study shows that the immunological features of severe COVID-19 are already present in healthy older adults and in men, before they are infected, indicating a possible explanation for this differential susceptibility towards the virus.

6 May 2021

Could stem cells improve the outcome of ARDS in severe COVID-19?

A recent study, published in Stem Cells Translational Medicine, explores the safety and efficacy of stem cells, which have been touted as the panacea for a wide range of illnesses, ranging from chronic degenerative conditions to cancer.

6 May 2021

About 84% of antibodies in plasma target non-RBD epitopes on SARS-CoV-2 spike protein, finds study

In a new study recently published in the journal Science, a team of researchers in the U.S. found that most of the antibodies circulating in the blood target areas of the viral spike protein outside the receptor-binding domain (RBD), the part of the spike that binds directly to human cell receptors.

6 May 2021

Researchers develop a multivalent vaccine for COVID-19 and influenza

Researchers at Duke University, USA, are looking into the possibility of a combined influenza and COVID-19 vaccine that could be used to simultaneously protect against annual flu strains and the SARS-CoV-2. Preclinical results showed the vaccine protected mice from both SARS-CoV-2 and the flu.

6 May 2021

Research shows how the world’s population has created an ideal breeding ground for infectious diseases

The way that many of us live has created the “perfect storm” for the evolution and transmission of infectious diseases like Covid-19 according to a researcher at the University of East Anglia.

6 May 2021

People with Covid-19 anxiety syndrome may find it harder to return to normal living after pandemic

‘Covid-19 anxiety syndrome’ may cause a significant number of people to struggle with reintegrating back into daily life as UK society returns to normal after the pandemic, says new research by London South Bank University (LSBU), in partnership with Kingston University.

6 May 2021

Study: Millions of COVID-19 cases can be prevented by reaching higher vaccination coverage levels

With around 30 percent of the U.S. population now fully vaccinated, the rate of daily vaccinations has started to slow, raising concerns that greater efforts and investments may be needed to reach higher coverage levels.

6 May 2021

Study examines artemisinin-based combination therapy as first-line treatment for malaria

When a mosquito begins to nibble on you, it is not merely feeding on your blood, it is also injecting its saliva into your skin. If that saliva happens to be full of parasites carrying malaria or other diseases from its last victim, then most likely you will become infected, too.

6 May 2021

WHO hails Sweden’s announcement to share 1 million doses of AstraZeneca vaccine with COVAX

WHO Dr Tedros Adhanom Ghebreyesus welcomed the Government of Sweden's announcement today to share 1 million doses of the AstraZeneca vaccine with the COVAX Facility to provide life-saving vaccines to people at risk from COVID-19 in low income countries.

6 May 2021

WHO and Federal Republic of Germany establish new global hub for pandemic and epidemic intelligence

The World Health Organization (WHO) and the Federal Republic of Germany will establish a new global hub for pandemic and epidemic intelligence, data, surveillance and analytics innovation.

6 May 2021

Study finds no evidence of increased risk for COVID-19 from aspirin/NSAID use

At the beginning of the pandemic, there were concerns over the use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), increasing the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. NSAIDs are commonly used to treat SARS-CoV-2 infection-related symptoms such as flu and cough and are frequently taken by older adults with multiple health conditions.

6 May 2021

Monocytes promote viral control during SARS-COV-2 infection

In a paper recently uploaded to the preprint server bioRxiv by Vanderheiden et al. (May 4th, 2021) the contribution of monocytes in promoting protective immunity from SARS-CoV-2 is investigated in a murine model, suggesting that CCR2 plays the role of an inflammation modulator in early infection.

6 May 2021

Experts and the public have underestimated the true extent of COVID-19 pandemic

Who made more accurate predictions about the course of the COVID-19 pandemic - experts or the public? A study from the University of Cambridge has found that experts such as epidemiologists and statisticians made far more accurate predictions than the public, but both groups substantially underestimated the true extent of the pandemic.

6 May 2021

Study: Second vaccine dose still makes organ transplant recipients vulnerable to COVID-19

In a study published today in the Journal of the American Medical Association (JAMA), Johns Hopkins Medicine researchers show that although two doses of a vaccine against SARS-CoV-2 - the virus that causes COVID 19 - confers some protection for people who have received solid organ transplants, it's still not enough to enable them to dispense with masks, physical distancing and other safety measures.

6 May 2021

FDA outlines inspectional activities during COVID-19 pandemic

Today, the U.S. Food and Drug Administration issued a new report titled, "Resiliency Roadmap for FDA Inspectional Oversight," outlining the agency's inspectional activities during the COVID-19 pandemic and its detailed plan to move toward a more consistent state of operations, including the FDA's priorities related to this work going forward.

6 May 2021

New study documents possible adverse events in relation to Vaxzevria COVID-19 vaccine

The new Danish-Norwegian study is the first study to document possible adverse events in relation to the COVID-19 vaccine Vaxzevria from AstraZeneca, in which all vaccine recipients have been followed systematically, as opposed to previous studies, which have relied primarily on reported adverse reactions.

6 May 2021

Researchers identify potent small molecule TMPRSS2 inhibitor against SARS-CoV-2

A team of scientists from the USA and Canada has recently identified and characterized a novel small-molecule compound inhibitor of cellular serine protease TMPRSS2, which shows significant antiviral potency against emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 May 2021

Novel pipeline identifies millions of molecular targets in SARS-CoV-2

Researchers in the United States have developed a novel pipeline for high-throughput, automated annotation of the genes, proteins and functional domains in the genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

5 May 2021

Disease/Infection News

SARS-CoV-2 is activated for fusion by a broad range of proteases, finds study

Transplant recipients with COVID-19 may show lower cellular and antibody immune responses

Aberrant immune features in healthy elderly and male subjects with severe COVID-19 may predate infection

Could stem cells improve the outcome of ARDS in severe COVID-19?

About 84% of antibodies in plasma target non-RBD epitopes on SARS-CoV-2 spike protein, finds study

Researchers develop a multivalent vaccine for COVID-19 and influenza

Research shows how the world’s population has created an ideal breeding ground for infectious diseases

People with Covid-19 anxiety syndrome may find it harder to return to normal living after pandemic

Study: Millions of COVID-19 cases can be prevented by reaching higher vaccination coverage levels

Study examines artemisinin-based combination therapy as first-line treatment for malaria

WHO hails Sweden’s announcement to share 1 million doses of AstraZeneca vaccine with COVAX

WHO and Federal Republic of Germany establish new global hub for pandemic and epidemic intelligence

Study finds no evidence of increased risk for COVID-19 from aspirin/NSAID use

Monocytes promote viral control during SARS-COV-2 infection

Experts and the public have underestimated the true extent of COVID-19 pandemic

Study: Second vaccine dose still makes organ transplant recipients vulnerable to COVID-19

FDA outlines inspectional activities during COVID-19 pandemic

New study documents possible adverse events in relation to Vaxzevria COVID-19 vaccine

Researchers identify potent small molecule TMPRSS2 inhibitor against SARS-CoV-2

Novel pipeline identifies millions of molecular targets in SARS-CoV-2

Advancing Motor Neuron Disease Diagnosis with Non-Invasive Ultrasound and AI

How agentic AI is reshaping laboratory workflows

Fourier 80: bringing benchtop NMR systems to the laboratory

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