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New Phase 1 clinical trial of investigational vaccine against B.1.351 SARS-CoV-2 variant begins

An investigational vaccine designed to protect against the B.1.351 SARS-CoV-2 variant has been administered as part of a new Phase 1 clinical trial evaluating the vaccine candidate's safety and immunogenicity in adult volunteers.

31 Mar 2021

Study details COVID-19 risk factors among long-stay nursing home residents in the U.S.

Risks of SARS-CoV-2 coronavirus infection for long-stay nursing home residents were mainly dependent on factors in their nursing homes and surrounding communities, according to a large study led by a researcher at the Johns Hopkins Bloomberg School of Public Health.

31 Mar 2021

Tamper-proof temperature indicator could help monitor ideal storage conditions of mRNA vaccines

Scientists have developed vaccines for COVID-19 with record speed. The first two vaccines widely distributed in the U.S. are mRNA-based and require ultracold storage (-70 C for one and -20 C for the other).

31 Mar 2021

New mRNA COVID-19 vaccine candidate shows promise in vivo

Researchers report that a new lipid nanoparticle mRNA coronavirus disease 2019 (COVID-19) vaccine candidate protected 70% of mice expressing the human angiotensin-converting enzyme 2 (ACE2), while all the non-vaccinated mice died.

31 Mar 2021

Are marine mammals are at risk of COVID-19?

Researchers have identified a number of marine mammal species native to Italian seawaters that may be highly susceptible to the disease. Additionally, these species inhabit ocean areas where the virus may be present even after receiving sewage treatment, thus highlighting the need for strict sewage improvement plans.

31 Mar 2021

Researchers evaluate antibodies that inhibit SARS-CoV-2 RBD variants with a novel assay

A team of researchers recently discussed the potential role of a new assay in bridging a major gap in SARS-CoV-2 research. This assay can throw light on 1) the selection of complementary monoclonal antibody candidates and 2) rapid identification of the immune escape to emerging RBD variants following vaccination or natural infection.

31 Mar 2021

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

The ongoing COVID-19 pandemic, caused by SARS-CoV-2, is now established to be more likely to lead to symptomatic and serious illness in males relative to females. This may extend as far back as pregnancy, suggests a recent study.

31 Mar 2021

Obesity and ethnicity identified as key risk factors for SARS-CoV-2 exposure in UK

The risk factors for severe COVID-19 have been established on the basis of observational studies. However, SARS-CoV-2 continues to cause thousands of COVID-19 cases all over the world, and the risk factors are unclear. A new study deals with this aspect of the pandemic.

31 Mar 2021

Infliximab may hinder the effectiveness of some COVID-19 vaccines

A new study reports reduced vaccine efficacy following the use of a single COVID-19 vaccine dose in people who are on the immunosuppressive monoclonal antibody Infliximab.

31 Mar 2021

Asymmetrical vaccine distribution could promote vaccine evading mutations in SARS-CoV-2

Researchers have investigated the ultimate influence of unequal vaccine distribution by mathematical modeling, revealing the critical role of fair distribution in future COVID-19 containment strategy.

31 Mar 2021

SARS-CoV-2 inhibits the cellular response to interferon

Researchers have explored the effect of SARS-CoV-2 infection on the function of RIG-I and MDA5, and ultimately on interferon production.

31 Mar 2021

Widely available drug reduces morbidity, mortality in COVID-19-infected mice

Mount Sinai researchers have found that a widely available and inexpensive drug targeting inflammatory genes has reduced morbidity and mortality in mice infected with SARS-CoV-2, the virus that causes COVID-19.

31 Mar 2021

COVID-19 patients with dementia have higher risk for complications, mortality

Early in the pandemic, neurologists expressed concern that COVID-19 patients with dementia may be at higher risk for complications and mortality.

31 Mar 2021

COVID-19 associated seizures may increase death risk in patients

COVID-19 can have damaging effects on multiple organs in the body, including the brain. A new study led by investigators at Massachusetts General Hospital (MGH) and Beth Israel Deaconess Medical Center (BIDMC) indicates that some hospitalized patients with COVID-19 experience non-convulsive seizures, which may put them at a higher risk of dying. The findings are published in the Annals of Neurology.

31 Mar 2021

Soft X-ray microscopy shows how viral pathogens penetrate human cells

How do viral pathogens succeed in penetrating human cells? Which cellular mechanisms do they use to multiply efficiently and, in doing so, how do they change the structure of their host cell? These questions are the focus of a pan-European research project called "Compact Cell-Imaging Device" (CoCID), in which Heidelberg scientists are playing a major role.

31 Mar 2021

NIAID researchers identify key player in the immune response to SARS-CoV-2

When variants of SARS-CoV-2 (the virus that causes COVID-19) emerged in late 2020, concern arose that they might elude protective immune responses generated by prior infection or vaccination, potentially making re-infection more likely or vaccination less effective.

31 Mar 2021

Disease/Infection News

New Phase 1 clinical trial of investigational vaccine against B.1.351 SARS-CoV-2 variant begins

Study details COVID-19 risk factors among long-stay nursing home residents in the U.S.

Tamper-proof temperature indicator could help monitor ideal storage conditions of mRNA vaccines

New mRNA COVID-19 vaccine candidate shows promise in vivo

Are marine mammals are at risk of COVID-19?

Researchers evaluate antibodies that inhibit SARS-CoV-2 RBD variants with a novel assay

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

Obesity and ethnicity identified as key risk factors for SARS-CoV-2 exposure in UK

Infliximab may hinder the effectiveness of some COVID-19 vaccines

Asymmetrical vaccine distribution could promote vaccine evading mutations in SARS-CoV-2

SARS-CoV-2 inhibits the cellular response to interferon

Widely available drug reduces morbidity, mortality in COVID-19-infected mice

COVID-19 patients with dementia have higher risk for complications, mortality

COVID-19 associated seizures may increase death risk in patients

Soft X-ray microscopy shows how viral pathogens penetrate human cells

NIAID researchers identify key player in the immune response to SARS-CoV-2

Study finds remarkable differences in the way individuals respond to malaria

Study shows how viral distribution of SARS-CoV-2 in the human body relates to tissue damage

New Columbia University center provides specialized care for Lyme and tick-borne diseases

Researchers analyze how in-person learning would impact transmission in schools' communities

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

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