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Statin use associated with reduction in mortality of patients with severe COVID-19

People who took statins to lower cholesterol were approximately 50% less likely to die if hospitalized for COVID-19, a study by physicians at Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian has found.

26 Feb 2021

Mobile phone app could help curb rabies threat in African cities

A mobile phone app is helping veterinarians to halve the time it takes to complete dog vaccination programmes in Malawi and could help curb rabies threat in African cities, a study shows.

26 Feb 2021

NLRP3 inflammasome inhibitors may help treat early COVID-19, says study

A new study by researchers in the U.S. further supports the hypothesis that the unregulated release of inflammatory cytokines is responsible for the local and systemic inflammation that is associated with multi-organ damage and death in severe COVID-19.

26 Feb 2021

South African SARS-CoV-2 variant partly resistant to neutralization by mRNA vaccine, says study

A new study deals with the clinical and virological effects of circulating SARS-CoV-2 variants, especially as they affect vaccine efficacy.

26 Feb 2021

Repurposed drugs show antiviral SARS-CoV-2 E channel blocking activity, finds study

A new study by researchers at The Hebrew University of Jerusalem in Israel reports the discovery of a promising group of E channel inhibitors with significant antiviral activity. This could be developed into new treatment agents for this often-deadly virus.

26 Feb 2021

Researchers develop new tool for predicting the effects of SARS-CoV-2 missense variants

A new study by a team of researchers in the UK and US describes the use of a computational tool that generates all possible single amino acid substitutions in SARS-CoV-2 and predicts their effects.

26 Feb 2021

Structure of SARS-CoV-2 envelope protein-epithelial cell junction protein complex explains virulence

A new study by researchers at Brookhaven National Laboratory and Stony Brook University in the U.S. describes the key interaction between the viral envelope (E) protein and the human cell junction protein, PALS1. The latter is necessary to establish and maintain cell polarity and tight junctions between cells.

26 Feb 2021

Inhalable nanobody shows potent anti-SARS-CoV-2 activity in vivo

Researchers have developed a stable and ultrapotent homotrimeric Pittsburgh inhalable Nanobody 21 (PiN-21) against SARS-CoV-2 infection in Syrian hamsters. They demonstrated the high therapeutic efficacy of this homotrimeric Nb, leveraging both intranasal and aerosol delivery.

26 Feb 2021

Single dose of Pfizer BioNTech vaccine can reduce asymptomatic SARS-CoV-2 infections

New data from Addenbrooke's Hospital in Cambridge suggests that a single dose of the Pfizer BioNTech vaccine can reduce by four-fold the number of asymptomatic SARS-CoV-2 infections.

26 Feb 2021

What is the impact of demographics and air quality on COVID-19 mortality?

A new piece of research was conducted using a wide range of variables related to demographic and environmental factors in New York State (NYS), USA. NYS consists of urban and ethnically diverse counties, some of which are population-dense while others are population-sparse.

26 Feb 2021

Is one dose of Pfizer-BioNTech mRNA vaccine for COVID-19 convalescents sufficient?

Researchers evaluated the immune response in a cohort of 1,089 healthcare workers who received the Pfizer-BioNTech vaccine in Southern California.

26 Feb 2021

Mandatory public health measures to combat COVID-19 are more effective, says study

In a new study, researchers at Lundberg Health Advocates and the Johns Hopkins Bloomberg School of Public Health in the U.S. compared mandatory and voluntary implementations of shelter-in-place policies. They assessed their respective bearings on COVID-19 mortality, equity, and economic outcomes.

26 Feb 2021

As Covid surged, vaccines came too late for at least 400 medical workers

As health care workers in the U.S. began lining up for their first coronavirus vaccines on Dec. 14, Esmeralda Campos-Loredo was already fighting for oxygen.

26 Feb 2021

Immunologists map unknown biological machinery to produce memory T cells

Immunologists at St. Jude Children's Research Hospital have mapped the previously unknown biological machinery by which the immune system generates T cells that kill bacteria, viruses and tumor cells.

26 Feb 2021

Researchers investigate the duration of the immune response to SARS-CoV-2

The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new Penn State-led study.

26 Feb 2021

New tool identifies security and privacy risks associated with COVID-19 contact tracing apps

Researchers have developed a tool to identify security and privacy risks associated with Covid-19 contact tracing apps.

26 Feb 2021

Study: Stay-at-home ordinance had positive effects on health and well-being of residents

A study by physiology researchers at The University of Texas at El Paso found that El Paso's stay-at-home ordinance due to the COVID-19 pandemic had positive effects on the health and well-being of the region's residents.

26 Feb 2021

Researchers propose new mechanism to promote access to COVID-19 vaccines

Although the value of vaccines for COVID-19 may seem obvious, government action and investment in vaccines have not been commensurate with the enormous scale of benefits they offer, argue Juan Camilo Castillo and colleagues in this Policy Forum.

26 Feb 2021

New test can detect viral infections in uncultured bacteria

The pandemic has made clear the threat that some viruses pose to people. But viruses can also infect life-sustaining bacteria and a Johns Hopkins University-led team has developed a test to determine if bacteria are sick, similar to the one used to test humans for COVID-19.

26 Feb 2021

LOINC receives additional federal funding to respond to COVID-19 pandemic

LOINC® at Regenstrief, an international health data standard critical to health information exchange, has received additional federal funding to support efforts to respond to the COVID-19 pandemic and future public health needs.

26 Feb 2021

Disease/Infection News

Statin use associated with reduction in mortality of patients with severe COVID-19

Mobile phone app could help curb rabies threat in African cities

NLRP3 inflammasome inhibitors may help treat early COVID-19, says study

South African SARS-CoV-2 variant partly resistant to neutralization by mRNA vaccine, says study

Repurposed drugs show antiviral SARS-CoV-2 E channel blocking activity, finds study

Researchers develop new tool for predicting the effects of SARS-CoV-2 missense variants

Structure of SARS-CoV-2 envelope protein-epithelial cell junction protein complex explains virulence

Inhalable nanobody shows potent anti-SARS-CoV-2 activity in vivo

Single dose of Pfizer BioNTech vaccine can reduce asymptomatic SARS-CoV-2 infections

What is the impact of demographics and air quality on COVID-19 mortality?

Is one dose of Pfizer-BioNTech mRNA vaccine for COVID-19 convalescents sufficient?

Mandatory public health measures to combat COVID-19 are more effective, says study

As Covid surged, vaccines came too late for at least 400 medical workers

Immunologists map unknown biological machinery to produce memory T cells

Researchers investigate the duration of the immune response to SARS-CoV-2

New tool identifies security and privacy risks associated with COVID-19 contact tracing apps

Study: Stay-at-home ordinance had positive effects on health and well-being of residents

Researchers propose new mechanism to promote access to COVID-19 vaccines

New test can detect viral infections in uncultured bacteria

LOINC receives additional federal funding to respond to COVID-19 pandemic

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

Todd Bauman and Chris Povich

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