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Ethacridine blocks SARS-CoV-2 with a distinct mode of action

Now, researchers from the University of California, San Francisco, and Stanford University, California, USA, reported a safe and potent antiseptic for use in humans named ethacridine, which effectively inhibits SARS-CoV-2 even at very low concentrations of EC50 ~ 0.08 µM. Their work has is published on the preprint server bioRxiv*.

1 Nov 2020

5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

Researchers tested 5-amino levulinic acid in vitro in human-derived cells and found it prevents severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Because it is safe and ubiquitous in plants and animals, it could be a potential drug against SARS-CoV-2.

1 Nov 2020

SARS-CoV-2 virus may target red marrow and prevent the formation of new erythrocytes

Specialists from the Department of Fundamental Medicine of Far Eastern Federal University (FEFU) with Russian and Japanese colleagues have probed into mechanisms of COVID-19 inside-the-body distribution linked to erythrocytes damaging.

30 Oct 2020

First-of-its-kind synthetic DNA vaccine designed against Powassan virus

Scientists at The Wistar Institute have designed and tested the first-of-its-kind synthetic DNA vaccine against Powassan virus (POWV), targeting portions of the virus envelope protein.

30 Oct 2020

Researchers seek to understand HIV-related attitudes of nursing faculty in six countries

Since the earliest study about nursing faculty and students attitudes and beliefs about caring for people living with HIV/AIDS (PLHIV) in the early 1990's, there have only been 17 additional studies. Knowledge in this area of study is still lacking to fill some gaps in understanding attitudes towards people living with the disease.

30 Oct 2020

Glucose-lowering drugs have neutral effect on mortality, adverse outcomes in COVID-19 patients with type 2 diabetes

In a preprint paper, "Impact of Glucose-Lowering Drugs on Mortality and Other Adverse Outcomes in Patients with Type 2 Diabetes Admitted for COVID-19," researchers conclude a neutral effect on mortality and other adverse outcomes.

30 Oct 2020

COVID-19 spreads faster and more widely in U.S. households, finds study

COVID-19 spreads faster and more widely throughout U.S. households than previously reported, according to new preliminary research from a multicenter study led by Vanderbilt University Medical Center researchers and published in MMWR, a weekly report from the Centers for Disease Control and Prevention.

30 Oct 2020

Terror groups exploit the mayhem during COVID-19 for spinning a plethora of sinister schemes

The uncertainty and confusion caused by the COVID-19 pandemic is being "widely exploited by terror groups for spinning a plethora of sinister schemes", which could lead to a new tide of violence against people and governments.

30 Oct 2020

Researchers identify new drug candidate with potential to treat COVID-19

Researchers from the University of Kent, the Goethe-University in Frankfurt am Main (Germany), and the Hannover Medical School (Germany) have identified a drug with the potential to provide a treatment for COVID-19.

30 Oct 2020

Study identifies new cause of inflammation in people living with HIV

While current antiretroviral treatments for HIV are highly effective, data has shown that people living with HIV appear to experience accelerated aging and have shorter lifespans - by up to five to 10 years - compared to people without HIV.

30 Oct 2020

IHR Emergency Committee on COVID-19 urges focus on evidence-based response efforts

The Emergency Committee on COVID-19 met on 29 October to review the situation and progress made on the temporary recommendations. They advised that the pandemic still constituted a public health emergency of international concern, and urged a focus on response efforts based on lessons learned and strong science.

30 Oct 2020

UIC enrolls people into phase 3 monoclonal antibody clinical trial

Researchers at the University of Illinois Chicago are now enrolling people into a phase 3 clinical trial that will test if a monoclonal antibody treatment -- administered as a series of four shots -- will help protect uninfected individuals from acquiring or getting sick from COVID-19 after someone in the household tests positive for COVID-19.

30 Oct 2020

Why state mask stockpiling orders are hurting nursing homes, small providers

Nursing homes, small physician offices and rural clinics are being left behind in the rush for N95 masks and other protective gear, exposing some of the country's most vulnerable populations and their caregivers to COVID-19 while larger, wealthier health care facilities build equipment stockpiles.

30 Oct 2020

New project to develop surgical technologies for COVID-19 receives €2.4 million funding

Irish medical tech firm Palliare leads EU H2020 research project with UCD using innovative optical technology for new safer surgery solution.

30 Oct 2020

Hospital floors create route of transfer of potentially dangerous organisms to patients

The floors of hospital rooms are quickly and frequently contaminated with antibiotic-resistant bacteria within hours of patient admission, creating a route of transfer of potentially dangerous organisms to patients, according to a study published today as part of the proceedings from Decennial 2020: The Sixth International Conference on Healthcare-Associated Infections.

30 Oct 2020

Experts call for transformative change to reduce future pandemics

Future pandemics will emerge more often, spread more rapidly, do more damage to the world economy and kill more people than COVID-19 unless there is a transformative change in the global approach to dealing with infectious diseases, warns a major new report on biodiversity and pandemics by 22 leading experts from around the world.

30 Oct 2020

APS technique shows how SARS-CoV-2 virus camouflages itself inside the human body

Scientists using the Advanced Photon Source have discovered new insights into the ways the SARS-CoV-2 virus camouflages itself inside the human body.

30 Oct 2020

Psychologists launch web-based contact tracing tool to slow spread of COVID-19

Psychologists have developed a do-it-yourself tool that uses "the science of memory" to improve the ability to remember more contacts during the contact tracing process.

30 Oct 2020

Study examines link between SARS-CoV-2 genomic load and COVID-19 patient outcomes

A new study published online in the Annals of the American Thoracic Society examines whether the amount of RNA, or genomic load, of SARS-CoV-2 detected in swab tests of patients being admitted to the hospital with viral pneumonia is associated with more severe COVID-19.

30 Oct 2020

SARS-CoV-2 spike proteins can directly impact the blood-brain barrier

Like a key, SARS-CoV-2 - the virus that causes coronavirus disease 2019 (COVID-19) - attaches to specific molecules on the host cell surface, opening gateways into the cell interior.

30 Oct 2020

Disease/Infection News

Ethacridine blocks SARS-CoV-2 with a distinct mode of action

5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

SARS-CoV-2 virus may target red marrow and prevent the formation of new erythrocytes

First-of-its-kind synthetic DNA vaccine designed against Powassan virus

Researchers seek to understand HIV-related attitudes of nursing faculty in six countries

Glucose-lowering drugs have neutral effect on mortality, adverse outcomes in COVID-19 patients with type 2 diabetes

COVID-19 spreads faster and more widely in U.S. households, finds study

Terror groups exploit the mayhem during COVID-19 for spinning a plethora of sinister schemes

Researchers identify new drug candidate with potential to treat COVID-19

Study identifies new cause of inflammation in people living with HIV

IHR Emergency Committee on COVID-19 urges focus on evidence-based response efforts

UIC enrolls people into phase 3 monoclonal antibody clinical trial

Why state mask stockpiling orders are hurting nursing homes, small providers

New project to develop surgical technologies for COVID-19 receives €2.4 million funding

Hospital floors create route of transfer of potentially dangerous organisms to patients

Experts call for transformative change to reduce future pandemics

APS technique shows how SARS-CoV-2 virus camouflages itself inside the human body

Psychologists launch web-based contact tracing tool to slow spread of COVID-19

Study examines link between SARS-CoV-2 genomic load and COVID-19 patient outcomes

SARS-CoV-2 spike proteins can directly impact the blood-brain barrier

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