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Fine tuning drug levels in neuroblastoma patients is effective

Monitoring and fine tuning the levels of the cancer drug topotecan in children with neuroblastoma holds promise for maximizing the drug's effectiveness while reducing its toxicity, according to investigators at St. Jude Children's Research Hospital.

19 Jun 2005

First blood test to help predict a patient's risk for ischemic stroke

The U.S. Food and Drug Administration (FDA) has approved the first blood test designed to help predict a patient's risk for ischemic stroke, the most common type of stroke and one of the nation's leading causes of long-term disability affecting approximately 700,000 people per year.

19 Jun 2005

Study shows why thiazolidinediones cause edema and helps understand role of kidneys in hypertension

In related discoveries with far-reaching implications for treating diabetes and understanding hypertension, University of Utah researchers have learned why thiazolidinediones (TZDs), a major anti-diabetes drug, cause edema and also have found a new pathway critical to fluid metabolism. Identification of this pathway may help understand fundamental mechanisms of blood pressure control.

19 Jun 2005

Brain size and intelligence are related

People with bigger brains are smarter than their smaller-brained counterparts, according to a study conducted by a Virginia Commonwealth University researcher published in the journal "Intelligence."

19 Jun 2005

Seroquel (quetiapine), may be an effective treatment option for patients with schizophrenia

A new study, published in the journal Human Psychopharmacology: Clinical and Experimental, shows that the atypical antipsychotic Seroquel (quetiapine), may be an effective treatment option for patients with schizophrenia who exhibit aggressive behaviour during psychotic episodes.

19 Jun 2005

Bipolar disorder more prevalent and costly than believed

The incidence of bipolar disorder in the general population is considerably higher than earlier studies have indicated, resulting in significantly less productivity and more days lost from work compared to the better known major depressive disorder, according to preliminary findings from a national survey presented today at the Sixth International Conference on Bipolar Disorder.

19 Jun 2005

High-volume medical centers better at treating cancer

Patients with certain complex cancers fare better under the care of doctors and hospitals that do the most of that kind of surgery, a new review of studies finds.

19 Jun 2005

Arterial spin labeling distinguishes between Alzheimer's disease and frontotemporal dementia

A non-invasive magnetic resonance imaging (MRI) technique called arterial spin labeling is just as accurate as invasive scanning techniques in distinguishing Alzheimer's disease from frontotemporal dementia (FTD) in the brains of elderly people, according to a new study at the San Francisco VA Medical Center (SFVAMC).

19 Jun 2005

Early exposure to inflammatory disease multiplies Alzheimer's risk

A new study of dementia in identical twins suggests that exposure to inflammation early in life quadruples one's risk of developing Alzheimer's disease.

19 Jun 2005

Female bed-rest study will understand changes to the immune response and decreased resistance to infection in space

A bed-rest study with female participants will help scientists understand changes to the immune response and decreased resistance to infection in space.

16 Jun 2005

Yet another proven benefit of tight glucose control for those with type 1 diabetes

New study results confirm, for the first time, that intensive treatment of diabetic patients results in a significantly lower risk of heart disease. In fact, it can cut the risk of cardiovascular disease nearly in half.

16 Jun 2005

Most common form of lung cancer may begin in a group of newly isolated lung stem cells

Working in a mouse model, the researchers isolated a novel type of lung cell that can divide into fresh copies of itself and into the two more specialized kinds of cells deep in the lung.

16 Jun 2005

New techniques use mitochondrial DNA as an early indicator for certain types of cancer

A pilot study at the National Institute of Standards and Technology (NIST), in support of the National Cancer Institute's Early Detection Research Network (EDRN), has validated the measurement accuracy of new techniques that use mitochondrial DNA as an early indicator for certain types of cancer.

16 Jun 2005

Transplantation of spermatogonial stem cells isolated from leukemic mice restores fertility without inducing leukemia

While more than 70% of patients survive childhood leukemia, curative chemotherapy can often irreversibly impair the formation of spermatozoa, causing infertility in males.

16 Jun 2005

Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer

Disruption of proteins expressed at the junctures between cells (known as tight junctions) is a hallmark of cancer cell invasion and spread (metastasis).

16 Jun 2005

Fine tuning drug levels in neuroblastoma patients is effective

16 Jun 2005

MRI measurement of breast tumor volume predicts whether a patient's cancer will return

The study, performed at the University of California-San Francisco, of 58 breast cancer patients found that the best way to predict a patient's recurrence-free survival is to review the initial MR examination (before the patient has chemotherapy) and the final MR examination (after chemotherapy has been completed).

16 Jun 2005

Drug Trial News

Fine tuning drug levels in neuroblastoma patients is effective

First blood test to help predict a patient's risk for ischemic stroke

Study shows why thiazolidinediones cause edema and helps understand role of kidneys in hypertension

Brain size and intelligence are related

Seroquel (quetiapine), may be an effective treatment option for patients with schizophrenia

Bipolar disorder more prevalent and costly than believed

High-volume medical centers better at treating cancer

Arterial spin labeling distinguishes between Alzheimer's disease and frontotemporal dementia

Early exposure to inflammatory disease multiplies Alzheimer's risk

Female bed-rest study will understand changes to the immune response and decreased resistance to infection in space

Yet another proven benefit of tight glucose control for those with type 1 diabetes

Most common form of lung cancer may begin in a group of newly isolated lung stem cells

New techniques use mitochondrial DNA as an early indicator for certain types of cancer

Transplantation of spermatogonial stem cells isolated from leukemic mice restores fertility without inducing leukemia

Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer

Fine tuning drug levels in neuroblastoma patients is effective

MRI measurement of breast tumor volume predicts whether a patient's cancer will return

Inactive gene may explain higher incidence of prostate cancer in African-Americans compared to Caucasians

People who have had a minor stroke have a 43% chance of another stroke or vascular event within 10-years

Single course of one antibiotic can successfully treat elephantiasis

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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