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Type 1 diabetes patients sought for UT Southwestern clinical drug trial

UT Southwestern Medical Center researchers are recruiting individuals newly diagnosed with type 1 diabetes for a clinical trial to gauge the effectiveness of adding an investigational stem cell product to standard insulin therapy.

3 Mar 2009

Angiogenesis inhibitors, study points to limitations, solutions

A new generation of cancer drugs designed to starve tumors of their blood supply - called "angiogenesis inhibitors"-succeeds at first, but then promotes more invasive cancer growth-sometimes with a higher incidence of metastases, according to a new study in animals.

2 Mar 2009

Biphasic insulin provides significant improvements in more than 52,000 diabetic patients

A major international diabetes study of more than 52,000 patients from eight countries has shown that using biphasic BIAsp 30 insulin resulted in significant clinical improvements and greater patient satisfaction.

2 Mar 2009

Chantix side effects no worse for people with history of depression

People with a likely history of depression who take varenicline (Chantix) do not report more severe mood symptoms, medication side effects, or less success quitting smoking compared to people with no history of depression taking this drug.

2 Mar 2009

Experimental drug fampridine improves mobility for some MS patients

In MS, the body's immune system attacks myelin, a fatty tissue that wraps and insultates nerve fibers, disrupting the transmission of signals in the central nervous system.

1 Mar 2009

Lab tests show meropenem and clavulanate combination effective against drug-resistant TB bacteria

WHAT: In a finding that could soon help people infected with untreatable, highly drug-resistant tuberculosis (TB), scientists have shown that two FDA-approved drugs work in tandem to kill laboratory-grown strains of Mycobacterium tuberculosis (Mtb), the bacterium that causes TB.

26 Feb 2009

Medivation announces new positive efficacy data from trial of MDV3100 in Castration-resistant prostate cancer

Medivation, Inc. has announced the presentation of new efficacy and safety data from an ongoing Phase 1-2 clinical trial of the Company's novel androgen receptor antagonist MDV3100 in castration-resistant prostate cancer (CRPC) patients.

25 Feb 2009

Goserelin improves long-term survival in premenopausal women with early breast cancer

Goserelin, a lutenizing hormone-releasing hormone agonist, reduces the long-term risk of disease recurrence and deaths in premenopausal women with early breast cancer who did not take tamoxifen, according to trial data reported in the February 24 online issue of the Journal of the National Cancer Institute.

24 Feb 2009

Bavarian Nordic updates on breast cancer vaccine studies

Bavarian Nordic today provided updated data from its clinical studies with its breast cancer vaccine, MVA-BN(R)-HER2, in development as therapy of metastatic breast cancer patients whose tumours over-express HER2.

23 Feb 2009

Neuralstem's ALS trial on hold

Neuralstem, Inc. has announced its spinal cord stem cell trial to treat Amyotrophic Lateral Sclerosis (ALS) is on clinical hold and that the Federal Drug Administration (FDA) has provided the Company with specific comments, questions and recommendations for modifications to its protocol.

22 Feb 2009

Questions of ethics and quality cloud globalization of clinical trials

Top-tier U.S.-based pharmaceutical companies are moving their clinical trials overseas at warp speed, raising questions about ethics, quality control, and even the scientific value of their findings for people back in the U.S.

20 Feb 2009

Optimizing dosage of blood-thinning drug warfarin

In a large-scale study and an upcoming clinical trial, scientists supported by the National Institutes of Health address one of the trickiest issues in prescribing medicine - how to quickly optimize each patient's dosage of the common blood-thinning drug warfarin.

20 Feb 2009

Drug sodium phenylbutyrate could improve the memory of those with Alzheimer's disease

The results of the project, developed by researchers of the Center for Applied Medical Research (CIMA) of the University of Navarra have been published in the journal Neuropsychopharmacology.

20 Feb 2009

Ondansetron shown to be a viable treatment option for opioid addiction

Scientists at Stanford University School of Medicine have discovered that a commonly available non-addictive drug can prevent symptoms of withdrawal from opioids with little likelihood of serious side effects.

18 Feb 2009

GlaxoSmithKline starts phase III trial of Syncria (albiglutide) type 2 diabetes medication

GlaxoSmithKline has announced initiation and dosing of the first patient of the Phase III clinical trial programme to evaluate the efficacy, safety and tolerability of the investigational GLP-1 (Glucagon-like peptide 1) agonist Syncria (albiglutide) in men and women with type 2 diabetes.

18 Feb 2009

Experimental antiarrhythmic drug dronedarone reduces death rate in patients with atrial fibrillation

Results from the ATHENA trial, reported in the 12th February issue of the New England Journal of Medicine , suggest that the (as yet unlicensed) antiarrhythmic drug dronedarone can reduce the incidence of cardiovascular-related hospitalisation or death in patients with atrial fibrillation.

16 Feb 2009

New trial targets kidney cancer drug sorafenib in bladder cancer

According to the American Cancer Society, 69,000 cases of bladder cancer were diagnosed nationwide last year with some 2,600 new cases in New Jersey.

16 Feb 2009

Avosentan shows prmoise for diabetic kidney disease

A new drug called avosentan significantly lowers urinary protein excretion-an important marker of kidney disease progression-in patients with diabetic kidney disease, according to an international clinical trial appearing in the March 2009 issue of the Journal of the American Society Nephrology (JASN).

16 Feb 2009

Trial of Quadramet (153 Samarium-lexidronam) in combo with Velcade shows positive results

Quadramet (153 Samarium-lexidronam) is a radioactive medication that targets the bone, specifically bone cancer, and is used to treat pain caused by cancer that has metastasized or spread to the bone.

15 Feb 2009

Study on ustekinumab for treatment of psoriatic arthritis published

A group of patients suffering from potentially debilitating psoriatic arthritis showed significant and prolonged improvement after treatment with ustekinumab, according to data from a randomized, double-blind, placebo-controlled study in patients with moderate to severe psoriatic arthritis (PsA).

11 Feb 2009

Drug Trial News

Type 1 diabetes patients sought for UT Southwestern clinical drug trial

Angiogenesis inhibitors, study points to limitations, solutions

Biphasic insulin provides significant improvements in more than 52,000 diabetic patients

Chantix side effects no worse for people with history of depression

Experimental drug fampridine improves mobility for some MS patients

Lab tests show meropenem and clavulanate combination effective against drug-resistant TB bacteria

Medivation announces new positive efficacy data from trial of MDV3100 in Castration-resistant prostate cancer

Goserelin improves long-term survival in premenopausal women with early breast cancer

Bavarian Nordic updates on breast cancer vaccine studies

Neuralstem's ALS trial on hold

Questions of ethics and quality cloud globalization of clinical trials

Optimizing dosage of blood-thinning drug warfarin

Drug sodium phenylbutyrate could improve the memory of those with Alzheimer's disease

Ondansetron shown to be a viable treatment option for opioid addiction

GlaxoSmithKline starts phase III trial of Syncria (albiglutide) type 2 diabetes medication

Experimental antiarrhythmic drug dronedarone reduces death rate in patients with atrial fibrillation

New trial targets kidney cancer drug sorafenib in bladder cancer

Avosentan shows prmoise for diabetic kidney disease

Trial of Quadramet (153 Samarium-lexidronam) in combo with Velcade shows positive results

Study on ustekinumab for treatment of psoriatic arthritis published

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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