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Candesartan cilexetil reduces proteinuria in kidney disease patients

Taking a much higher than recommended dose of the hypertension drug candesartan cilexetil effectively lowered the amount of protein excreted in the urine of patients with kidney disease, according to a study appearing in the April 2009 issue of the Journal of the American Society Nephrology ( JASN ).

11 Feb 2009

ViroPharma reports results of trial for Maribavir in bone marrow transplant patients

ViroPharma Incorporated has announced that its Phase 3 trial evaluating maribavir used as prophylaxis in allogeneic stem cell, or bone marrow, transplant (SCT) patients did not achieve its primary endpoint.

10 Feb 2009

Atorvastatin and lovastatin found to be ineffective for breast cancer prevention

Laboratory work in animals showed limited activity when statins were given to prevent breast cancer, according to a report in the February issue of Cancer Prevention Research , a journal of the American Association for Cancer Research.

8 Feb 2009

Study tests salsalate anti-inflammatory for poorly controlled type 2 diabetes

Researchers in 20 medical centers across the country are enrolling adults with type 2 diabetes who have poorly controlled blood glucose to participate in a clinical study, Targeting Inflammation with Salsalate in Type 2 Diabetes (TINSAL-T2D).

5 Feb 2009

Sangamo BioSciences starts trial of CCR5-ZFP therapeutic to treat HIV/AIDS

Sangamo BioSciences, Inc. has announced that its collaborators at the University of Pennsylvania have opened a Phase 1 clinical trial to evaluate SB-728-T for the treatment of HIV/AIDS.

5 Feb 2009

Safinamide significantly improved motor function in patients with advanced Parkinson's disease

Merck Serono, a division of Merck KGaA, Darmstadt, Germany, and its partner Newron Pharmaceuticals SpA has announced that the first Phase III trial of investigational agent safinamide as adjunctive therapy to levodopa (study 016) met its primary endpoint by increasing daily "ON" time in mid- to late-stage Parkinson's disease patients with motor fluctuations by 1.3 hours.

5 Feb 2009

Fasudil could reduce risk of Alzheimer's

A drug used to improve blood flow to the brain also could help improve learning and memory and reduce the risk of Alzheimer's disease, according to a new study released today by investigators at the Translational Genomics Research Institute (TGen) and Arizona State University.

2 Feb 2009

Sedative dexmedetomidine may offer advantages over agents often used for sedation in ICU

Use of the sedative dexmedetomidine for critically ill patients resulted in less time on a ventilator and less delirium compared to patients administered a more commonly used drug, according to a study in the February 4 issue of JAMA, the Journal of the American Medical Association.

2 Feb 2009

Antiepileptic drug vigabatrin may decrease spasms for infants with epilepsy

The antiepileptic drug vigabatrin (VGB) has been shown to be one of the best treatments against a special form of epilepsy in infants, called infantile spasm.

2 Feb 2009

Century old drug clofazimine shows potential for multiple sclerosis

A century-old drug that failed in its original intent to treat tuberculosis but has worked well as an antileprosy medicine now holds new promise as a potential therapy for multiple sclerosis and other autoimmune diseases.

2 Feb 2009

Infliximab after intestinal resective surgery may help prevent post-op Crohn's disease recurrence

The administration of infliximab after intestinal resective surgery was found to be effective at preventing endoscopic and histological recurrence of Crohn's disease, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

2 Feb 2009

Study of cannabinoid medicine for pain found patients got 'high,' but effects not related to pain relief

Researchers at Brigham and Women's Hospital found that patients taking cannabinoid medicines for pain may be getting "high," but these effects were unrelated to relief from their pain symptoms. Results of their study, one of the first to examine the addictive potential of this class of pain medicine, were presented today at the American Academy of Pain Medicine's 25th Annual Meeting.

29 Jan 2009

Leconotide, an investigative calcium channel blocker, shows potential as pain treatment

Results of a pre-clinical study of leconotide, an investigative calcium channel blocker, shows it has the potential to be safe, selective, and efficacious as a new non-opioid treatment for pain relief. It also holds promise in multiple drug delivery options including nasal spray, transdermal patch, and pills. Data were presented today at the American Academy of Pain Medicine's 25th Annual Meeting.

29 Jan 2009

Early treatment with rasagiline (Azilect) for Parkinson's best

There is hope that the drug rasagiline can do what no other medication for Parkinson's disease now does -- slow the progression of a devastating degenerative brain disease that eventually robs people of their ability to move and function.

27 Jan 2009

Lisofylline drug improves type 2 insulin action; reduces harm of fat in preclinical study

Results of a preclinical study involving DiaKine Therapeutics' lead drug candidate Lisofylline (LSF) indicate the compound may reduce two key risk factors for type 2 diabetes.

23 Jan 2009

Cream containing tretinoin associated with death in clinical trial, but relationship does not appear causal

Patients using a cream containing tretinoin, a retinoid commonly used to treat acne and other conditions, appeared more likely to die than those using a placebo in a clinical trial that was halted early as a result, according to a report in the January issue of Archives of Dermatology.

19 Jan 2009

Pre-emptive treatment helped curtail skin toxicity with Panitumumab

With a pre-emptive, prophylactic skin regimen, patients who receive panitumumab for treatment of metastatic colorectal cancer may be able to avoid some of the skin-associated toxicities, according to data presented at the 2009 American Society of Clinical Oncology Gastrointestinal Cancers Symposium in San Francisco.

19 Jan 2009

Combo malaria treatment dihydroartemisinin and piperaquine shows promise

The results of two new large scale trials show that the combination of dihydroartemisinin and piperaquine (DHA+PQP) not only is effective against uncomplicated malaria in a way which is comparable to other artemisinin-based combination therapies (ACTs), but it also protects patients against new infections for at least two months after treatment.

19 Jan 2009

Algeta completes phase II trial with Alpharadin for treating bone metastases in advanced prostate cancer

Algeta ASA has announced that with the results of the BC1-04 study reported today it has completed its comprehensive phase II clinical program evaluating Alpharadin (radium-223) as a new treatment for bone metastases in patients with hormone-refractory prostate cancer (HRPC).

15 Jan 2009

Discovery of better treatment for bacterial pneumonia

Scientists at St. Jude Children's Research Hospital have demonstrated a more effective treatment for bacterial pneumonia following influenza.

9 Jan 2009

Drug Trial News

Candesartan cilexetil reduces proteinuria in kidney disease patients

ViroPharma reports results of trial for Maribavir in bone marrow transplant patients

Atorvastatin and lovastatin found to be ineffective for breast cancer prevention

Study tests salsalate anti-inflammatory for poorly controlled type 2 diabetes

Sangamo BioSciences starts trial of CCR5-ZFP therapeutic to treat HIV/AIDS

Safinamide significantly improved motor function in patients with advanced Parkinson's disease

Fasudil could reduce risk of Alzheimer's

Sedative dexmedetomidine may offer advantages over agents often used for sedation in ICU

Antiepileptic drug vigabatrin may decrease spasms for infants with epilepsy

Century old drug clofazimine shows potential for multiple sclerosis

Infliximab after intestinal resective surgery may help prevent post-op Crohn's disease recurrence

Study of cannabinoid medicine for pain found patients got 'high,' but effects not related to pain relief

Leconotide, an investigative calcium channel blocker, shows potential as pain treatment

Early treatment with rasagiline (Azilect) for Parkinson's best

Lisofylline drug improves type 2 insulin action; reduces harm of fat in preclinical study

Cream containing tretinoin associated with death in clinical trial, but relationship does not appear causal

Pre-emptive treatment helped curtail skin toxicity with Panitumumab

Combo malaria treatment dihydroartemisinin and piperaquine shows promise

Algeta completes phase II trial with Alpharadin for treating bone metastases in advanced prostate cancer

Discovery of better treatment for bacterial pneumonia

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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