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Study shows decline in work disability due to rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting the joints and, in severe cases, vital organs.

15 Apr 2008

Study details cost-effectiveness of rheumatoid arthritis treatments for Medicare recipients

For elderly and disabled rheumatoid arthritis (RA) sufferers, the Medicare Prescription Drug Improvement and Modernization Act (MMA) brought the promise of better disease management with "biologic" drugs.

15 Apr 2008

Statins may modestly reduce blood pressure

The medications known as statins, typically prescribed to lower blood cholesterol levels, may also modestly reduce blood pressure, according to a report in the April 14 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

15 Apr 2008

Regulating hematopoietic stem cell homeostasis and leukemogenesis

In the April 15th issue of G&D, Dr. Richard Flavell (Yale University) and colleagues identify the c-Cbl protein as a critical repressor of hematopoietic stem cell (HSC) self-renewal.

15 Apr 2008

Potential treatment for multiple sclerosis goes to trial

A potential treatment for multiple sclerosis (MS), developed by University of Greenwich in association with Kings College, London, has begun clinical trials.

15 Apr 2008

NovoCure presents results from breast cancer pilot study

NovoCure announced today that it presented the results from a single-arm pilot trial evaluating the Novo-TTF, a non-invasive portable medical device, combined with neo-adjuvant chemotherapy for the treatment of patients with locally advanced breast cancer.

15 Apr 2008

New insight into the pathogenesis of neurodegeneration in Ataxia telangiectasia

An upcoming paper from Dr. David Wassarman (University of Wisconsin School of Medicine and Public Health) in the May 1 issue of G&D lends new insight into the pathogenesis of neurodegeneration in Ataxia telangiectasia.

15 Apr 2008

High blood pressure may play a role in protecting against migraine

People with high blood pressure appear to be less likely to have migraine than those with low blood pressure.

15 Apr 2008

Elevated levels of antioxidant urate may slow Parkinson's progression

Naturally elevated levels of the antioxidant urate may slow the progression of Parkinson's disease in men. Researchers from the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND) and Harvard School of Public Health (HSPH) examined data from an earlier study and found that, among recently diagnosed Parkinson's patients, those with the highest urate levels had a significantly slower rate of disease progression during the two-year study period.

15 Apr 2008

Very early photoscreening yields better visual outcomes in amblyopia treatment

Children who screen positive for amblyopia, reduced vision in one eye, before age 2 appear to have better visual outcomes than those whose vision problems are detected during screenings between ages 2 and 4, according to a report in the April issue of Archives of Ophthalmology, one of the JAMA/Archives journals.

15 Apr 2008

DASH diet also may cut risk for heart disease, stroke

Women who eat diets similar to the Dietary Approaches to Stop Hypertension (DASH) diet -which is low in animal protein, moderate in low-fat dairy products and high in plant proteins, fruits and vegetables - appear to have a lower risk of coronary heart disease and stroke, according to a report in the April 14 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

15 Apr 2008

Restricted-calorie diets limit development of epithelial cancers

A restricted-calorie diet inhibited the development of precancerous growths in a two-step model of skin cancer, reducing the activation of two signaling pathways known to contribute to cancer growth and development, researchers at The University of Texas M. D. Anderson Cancer Center report today at the American Association for Cancer Research annual meeting.

15 Apr 2008

Brain study may lead to improved epilepsy treatments

Using a rodent model of epilepsy, researchers found one of the body's own neurotransmitters released during seizures, glutamate, turns on a signaling pathway in the brain that increases production of a protein that could reduce medication entry into the brain.

15 Apr 2008

Blood urate levels associated with the progression of Parkinson's disease

Higher blood levels of the compound urate, a salt derived from uric acid that is associated with gout, may be associated with a slower progression of Parkinson's disease, according to an article posted online today that will appear in the June 2008 print issue of Archives of Neurology.

15 Apr 2008

Best use for popular CAD assessment procedure is misunderstood

What is the best way to determine if you are developing the nation's most deadly condition, coronary artery disease (CAD)?

15 Apr 2008

Statins may help control blood pressure

Researchers in the States say that statins, the popular cholesterol-lowering drugs, may also lower blood pressure.

15 Apr 2008

Traffic pollution linked to thousands of deaths from pneumonia

British researchers are suggesting that high levels of pollution may have contributed to the deaths in recent years of thousands of people in England from pneumonia.

15 Apr 2008

Low birth weight linked to heart disease

According to new research from Britain, being small at birth along with an excessive weight gain during adolescence and young adulthood are indicators for future heart disease risk.

14 Apr 2008

Researchers study Rituximab's action on cancer stem cells

Preliminary data from one of the first clinical trials to test a stem cell-targeting drug in cancer patients shows that while the drug did not prolong survival, its suppressing effect on patients' stem cells was impressive enough to send investigators looking for a better drug to try.

13 Apr 2008

Targeted therapy combo overcomes treatment resistance in liver cancer

Researchers at the University of Pennsylvania School of Medicine and Abramson Cancer Center reported at the annual meeting of the American Association for Cancer Research that combining two targeted therapies overcomes treatment resistance in liver cancer cell lines.

13 Apr 2008