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The 30-year natural history of type 1 diabetes complications

...while cases of premature death and a few other complications have declined, rates of other serious diabetes-related disorders such as heart and eye disease have not improved over the past 25 to 30 years.

3 May 2006

Initial experience of FDG-PET/CT guided IMRT of head and neck carcinoma

Doctors have discovered that combining images derived from positron emission tomography and computed tomography in the planning and delivery of radiation treatment for patients with head and neck cancer leads to more accurate delivery of the radiation dose and an increased chance for survival.

3 May 2006

Early myocardial enhancement defects (dark spots) on multidetector CT are valuable predictors of myocardial viability

...in patients who have suffered a heart attack, reported doctors from the departments of cardiology and radiology at Rambam Medical Center in Haifa, Israel.

3 May 2006

Risk of secondary malignancies in testicular cancer

While in the United States the preferred treatment for stage I mixed germ cell tumors has been retroperitoneal lymphadenectomy, adjuvant chemotherapy has been more commonly used in Europe.

2 May 2006

Do symptoms correlate with cystoscopic findings in newly diagnosed PBS/IC?

In patients with untreated and newly diagnosed PBS/IC, can one find a correlation between symptoms and cystoscopic findings?

2 May 2006

Does an association between prostate cancer and military service in Vietnam exist?

Men in the armed forces who served in Vietnam may have been exposed to Agent Orange, the defoliate that potentially is associated with causing prostate cancer (CaP).

2 May 2006

British healthier than Americans in middle-age

According to a large international study middle-aged Americans are not as healthy as their British cousins.

2 May 2006

Significant number of women believe their children are normal weight when they are actually overweight

Latina mothers of preschool-aged children frequently have inaccurate perceptions of their children's body mass index and believe they are healthy when they are overweight, according to a new study from the University of California, San Francisco.

2 May 2006

Ability to complete quarter-mile walk a powerful predictor of health outcomes in elderly

Walking fitness makes a significant difference in predicting the likelihood of future disability in the elderly, according to a study published today in the Journal of the American Medical Association.

2 May 2006

Study investigates early biology of HIV infection

In July 2005, the race to find a vaccine that would stem the worldwide rate of 13,000 new cases of HIV infection each day moved from competition among research institutions to a strategy of cooperation.

2 May 2006

Peplin announces positive results of skin cancer trial

Peplin Limited today announced positive results from its Australian phase IIa clinical trial of its proprietary drug PEP005 Topical in superficial forms of basal cell carcinoma (sBCC) the most common form of skin cancer.

1 May 2006

Polycomb proteins key factors in influencing the direction of embryonic stem cell development

Embryonic stem cells may one day provide a means to treat disease, but according to two new reports, they are already revealing remarkable insights into the mysteries of human biology. How humans manage to develop from a single fertilized egg into the trillions of cells that make up a mature adult remains a poorly understood process. Now, using both human and mouse embryonic stem cells, researchers have mapped how a key developmental ingredient controls the genome.

28 Apr 2006

Discovery brings embryonic stem cell medicine a step closer

A team of scientists announced a critical step on the path of realizing the promise of embryonic stem (ES) cells for medicine. The researchers have discovered unique molecular imprints coupled to DNA in mouse ES cells that help explain the cells' rare ability to form almost any body cell type. These imprints, or "signatures," appear near the master genes that control embryonic development and probably coordinate their activity in the early stages of cell differentiation. Not only do these findings help to unlock the basis for ES cells' seemingly unlimited potential, they also suggest ways to understand why ordinary cells are so limited in their abilities to repair or replace damaged cells.

26 Apr 2006

Studies indicate stem cells are flexible enough to become any cell in the body

Two studies in the April 21, 2006 Cell report new details of the "genetic program" that affords embryonic stem cells the flexibility to give rise to any cell type in the body. Both groups identified mechanisms by which the embryonic stem cells of mice or humans keep from going down any one particular developmental path--that of muscle or nervous tissue, for example--while remaining "poised for activation."

26 Apr 2006

Studies indicate stem cells are flexible enough to become any cell in the body

26 Apr 2006

Enhancing the function of the protein SOCS3 could be a more effective way to regulate cell responses

A discovery made at The Walter and Eliza Hall Institute provides new insights into enhancing the function of the protein SOCS3, which regulates the response of cells to external stimuli.

26 Apr 2006

Caspase-12 antagonists could potentially be useful in the treatment of sepsis and other inflammatory and immune disorders

According to the new study, the presence of caspase-12, which appears to modulate inflammation and innate immunity in humans, increases the body's "vulnerability to bacterial infection and septic shock" while a deficiency confers strong resistance to sepsis. This new discovery suggests that caspase-12 antagonists could be a potentially useful in the treatment of sepsis and other inflammatory and immune disorders.

26 Apr 2006

Groups better at solving problems than individuals

Study shows that the collective efforts of groups may be useful in boosting problem-solving skills. It found groups of three, four, or five perform better on complex problem solving than the best of an equivalent number of individuals.

24 Apr 2006

Non-Smokers with lung cancer respond better to treatment than smokers

Smoking history contributes to poor outcomes in the treatment of lung cancer, according to a new study. Non-small cell lung cancer (NSCLC) lung cancer patients who have never smoked before in their life have better overall survival rates and respond better to chemotherapy than current or former smokers.

24 Apr 2006

Study reveals findings on how insulin-producing beta cells grow and function

A new Joslin Diabetes Center-led study has shown conclusively that two receptors in the insulin-producing beta cell do not affect developmental growth, refuting a long-held hypothesis in diabetes research.

23 Apr 2006