Genomics

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Researchers turn to single-cell analysis to understand a pediatric brain tumor

Investigators at St. Jude Children's Research Hospital and Massachusetts General Hospital, alongside others, have revealed the cells of origin for specific subtypes of medulloblastoma, the most common malignant pediatric brain tumor.

25 Jul 2019

Exosomes can restore health to brain cells affected by developmental disease

Like overpacked suitcases unloaded from the underbelly of a jet, molecular satchels called exosomes are continuously deployed from all cells in the body—each one brimming with an assortment of contents that another cell may unpack and use.

23 Jul 2019

Scientists confirm HIV theory by sequencing 53-year old tissue

Researchers have extracted a near-complete HIV-1 genome from the lymph node tissue of a man who has been embedded in wax since 1966.

22 Jul 2019

Genetic similarities of deadly bone cancer between dogs and children revealed

A bone cancer known as osteosarcoma is genetically similar in dogs and human children, according to the results of a study published today by Tufts University and the Translational Genomics Research Institute, an affiliate of City of Hope.

21 Jul 2019

Study provides new insight into how changes in DNA methylation contribute to diseases

More than half of our genome consists of transposons, DNA sequences that are reminiscent of ancient, extinct viruses.

19 Jul 2019

NIH researchers report largest genomic study of type 2 diabetes in sub-Saharan Africans

National Institute of Health researchers have reported the largest genomic study of type 2 diabetes in sub-Saharan Africans, with data from more than 5,000 individuals from Nigeria, Ghana and Kenya.

19 Jul 2019

IDT partners with Washington University to increase access to new NGS technologies

As part of its commitment to advocate for the genomics age, Integrated DNA Technologies aims to lower the barriers to access the latest NGS technologies.

From Integrated DNA Technologies 19 Jul 2019

Group of genes linked to longer lifespan in fruit flies discovered

Alexey Moskalev, Ph.D., Head of the Laboratory of Geroprotective and Radioprotective technologies, and co-authors from the Institute of biology of Komi Science Center of RAS, the Engelgard's Institute of molecular biology of RAS and Moscow Institute of Physics and Technology published a scientific article titled "Transcriptome Analysis of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity" in Nature Scientific Reports - the leading international multidisciplinary weekly journal.

19 Jul 2019

How genetic differences in Epstein-Barr virus strains alter the way it behaves

Researchers at the University of Sussex have identified how differences in the genetic sequence of the two main strains of the cancer-associated Epstein-Barr virus can alter the way the virus behaves when it infects white blood cells.

19 Jul 2019

AEBP1 gene may play key role in the development and severity of liver disease

Researchers have found that a gene known as AEBP1 may play a central role in the development, severity and potential treatment of liver disease, according to a study by Temple University, the Geisinger Obesity Institute and the Translational Genomics Research Institute, an affiliate of City of Hope.

18 Jul 2019

Researchers develop a more precise version of CRISPR-Cas9 gene-editing system

A gene defect in humans causes progressive hearing loss in humans, resulting in deafness by their mid-20s. The same genetic mutation causes deafness in the Beethoven-mouse model.

18 Jul 2019

Researchers reveal molecular cause for severe multi-organ disorder

Three unrelated families on three continents (from continental Portugal, the United States and Brazil), all with healthy ancestors, had children with a very rare disease.

18 Jul 2019

Research team detects novel mechanism of inheritance

Non-Mendelian, oligogenic inheritance could bean unrecognized and important element for occurrence ofhereditary retinal degenerations (HRDs, comprising retinitis pigmentosa) which are caused by ultra-rare mutations and cause progressive blindness.

18 Jul 2019

New research could help design algae that produces fuels and cleanup chemicals

It's a case of grand larceny that could lead to new fuels and cleanup chemicals. Ten species of red algae stole about 1 percent of their genes from bacteria to cope with toxic metals and salt stress in hot springs, according to a study in the journal eLife.

18 Jul 2019

Scientists discover how resistance to the chemotherapy drug 5-fluorouracil arises

Australian researchers have unlocked the mystery as to why the chemotherapy drug 5-Fluorouracil is not effective at treating certain cancers.

17 Jul 2019

Molecular switches may control lifespan and healthspan separately, genetic discovery suggests

Aging research indicates that better healthspan--the quality of life as we age--may be more important than lifespan.

17 Jul 2019

Researchers identify chemical compounds that increase stability of haploid cell

Since the emergence of molecular genetics more than fifty years ago, scientists have tried to isolate haploid mammalian cells, that is, cells with half the number of chromosomes contained in somatic cells. Haploid cells are a powerful genetic tool to analyze gene function.

17 Jul 2019

Study identifies genomic differences that impact response to Cryptococcus infection

Cryptococcus neoformans is a fungal pathogen that infects people with weakened immune systems, particularly those with advanced HIV/AIDS. New University of Minnesota Medical Research could mean a better understanding of this infection and potentially better treatments for patients.

16 Jul 2019

New method spots rare immune cells reactive against cancer

Researchers from the Garvan Institute of Medical Research have developed a new method to spot rare immune cells that are reactive against cancer cells, from within a patient's own immune system.

16 Jul 2019

Inhibition of p38 protein boosts formation of blood vessels in colon cancer

A study performed at the Institute for Research in Biomedicine and published in the journal Nature Communications demonstrates that inhibition of the p38 protein boosts the formation of blood vessels in human and mice colon cancers.

16 Jul 2019