Genomics

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Elevated levels of suPAR protein combine with genetic mutation to trigger CKD in black people

Between 15 and 20 percent of black people carry a genetic mutation that puts them at risk for certain chronic kidney disease, but only about half of them develop the illness – a variance that long has puzzled researchers.

27 Jun 2017

Study sheds light on night work−cancer link

A new study has offered insights into the association between night shift work and increased cancer risk, as well as pointing towards a potential solution. For several years, scientists have thought that disruption to the body’s natural circadian rhythm is accountable for the increased cancer risk, but the mechanisms behind this have not yet been pinpointed.

27 Jun 2017

Innate immune cells of myeloid lineage play central role in AD pathogenesis than previously thought

Many genes linked to late-onset Alzheimer's disease (AD) are expressed in myeloid cells and regulated by a single protein, according to research conducted at the Icahn School of Medicine at Mount Sinai and published June 19 in the journal Nature Neuroscience.

27 Jun 2017

Existing drugs could help subgroup of patients with osteosarcoma, suggest scientists

A subgroup of patients with osteosarcoma - a form of bone cancer - could be helped by an existing drug, suggest scientists from the Wellcome Trust Sanger Institute and their collaborators at University College London Cancer Institute and the Royal National Orthopaedic Hospital NHS Trust.

23 Jun 2017

Cancer cells may lose copies of ribosomal DNA to enable faster proliferation, study shows

Research from the Stowers Institute provides evidence suggesting that cancer cells might streamline their genomes in order to proliferate more easily.

23 Jun 2017

Scientists discover link between sugar metabolism and peroxisomal biogenesis disorders

Meeting a young patient with Zellweger syndrome, a rare, life-threatening genetic disease, started a scientific investigation that culminated with an unexpected discovery.

23 Jun 2017

Researchers identify first definitive risk genes for Tourette Syndrome

An international team that just conducted the largest study of Tourette Syndrome has identified genetic abnormalities that are the first definitive risk genes for the disorder.

23 Jun 2017

Wasp venom provides clues to how genes take on new functions

Amid the incredible diversity of living things on our planet, there is a common theme. Organisms need to acquire new genes, or change the functions of existing genes, in order to adapt and survive.

22 Jun 2017

Could the mTOR pathway be used to protect against cancer?

The mTOR pathway is probably the main pathway in humans and other animals that drives growth. That is, the accumulation of mass and adding mass to make an organism bigger by both making more cells, and making cells grow and become bigger.

22 Jun 2017

New approach finds statistical evidence that ancient gene variants contribute to autism

The way you measure things has a lot to do with the value of the results you get. If you want to know how much a blueberry weighs, don't use a bathroom scale; it isn't sensitive enough to register a meaningful result.

22 Jun 2017

Genetic factors play significant role in causing ALS, study reveals

Up to 90 percent of people with amyotrophic lateral sclerosis (ALS) report that they have no family history of the disease.

22 Jun 2017

Study identifies structural changes in genes that increase risk of Tourette syndrome

Researchers have identified structural changes in two genes that increase the risk of developing Tourette syndrome, a neurological disorder characterized by involuntary motor and vocal tics.

21 Jun 2017

Finnish researchers find accumulation of gene mutations in some patients with rheumatoid arthritis

Gene mutations accumulating in cells are typical of the development of cancer. Finnish researchers found that a similar accumulation of mutations occurs also in some patients with rheumatoid arthritis.

21 Jun 2017

Type I interferons could have role in natural improvement of RA during pregnancy

An international US-Danish team of scientists, led by Damini Jawaheer, Ph.D. at the UCSF Benioff Children's Hospital Oakland Research Institute, has identified a possible link between type I interferons and a natural improvement of rheumatoid arthritis (RA) during pregnancy.

21 Jun 2017

Vast numbers of peripheral genes can influence diseases, Stanford researchers suggest

A core assumption in the study of disease-causing genes has been that they are clustered in molecular pathways directly connected to the disease. But work by a group of researchers at the Stanford University School of Medicine suggests otherwise.

20 Jun 2017

Researchers identify new disease gene for early-onset axonal neuropathy and mild intellectual disability

Research group from the University of Helsinki, Finland, has identified a new disease gene for early-onset axonal neuropathy and mild intellectual disability through an international research network, which was brought together by "Tinder for geneticists".

20 Jun 2017

Research provides insight into role of APP gene variant in Alzheimer’s disease

New research from the University of Eastern Finland shows that the APP gene variant protecting against Alzheimer's disease significantly decreases plasma beta-amyloid levels in a population cohort.

20 Jun 2017

Genetic mutation could be cause of severe eczema, research finds

A genetic mutation could be the cause of severe eczema, according to new research published June 19 in Nature Genetics by researchers at the Uniformed Services University of the Health Sciences.

20 Jun 2017

Research findings lay groundwork for developing more targeted treatments for deadly neuroblastomas

Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research by the University of Chicago Medicine. The findings lay the groundwork for developing more targeted treatments for particularly deadly variations of the cancer.

20 Jun 2017

Researchers discover single microglial protein that regulates AD risk genes

Genetic studies have turned up numerous genes linked to Alzheimer's disease, but in most cases, researchers have no idea how the genes raise or lower risk.

19 Jun 2017

Genomics

Elevated levels of suPAR protein combine with genetic mutation to trigger CKD in black people

Study sheds light on night work−cancer link

Innate immune cells of myeloid lineage play central role in AD pathogenesis than previously thought

Existing drugs could help subgroup of patients with osteosarcoma, suggest scientists

Cancer cells may lose copies of ribosomal DNA to enable faster proliferation, study shows

Scientists discover link between sugar metabolism and peroxisomal biogenesis disorders

Researchers identify first definitive risk genes for Tourette Syndrome

Wasp venom provides clues to how genes take on new functions

Could the mTOR pathway be used to protect against cancer?

New approach finds statistical evidence that ancient gene variants contribute to autism

Genetic factors play significant role in causing ALS, study reveals

Study identifies structural changes in genes that increase risk of Tourette syndrome

Finnish researchers find accumulation of gene mutations in some patients with rheumatoid arthritis

Type I interferons could have role in natural improvement of RA during pregnancy

Vast numbers of peripheral genes can influence diseases, Stanford researchers suggest

Researchers identify new disease gene for early-onset axonal neuropathy and mild intellectual disability

Research provides insight into role of APP gene variant in Alzheimer’s disease

Genetic mutation could be cause of severe eczema, research finds

Research findings lay groundwork for developing more targeted treatments for deadly neuroblastomas

Researchers discover single microglial protein that regulates AD risk genes

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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