Genomics

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Molecular pathways underlying myopia open new ways for drug development

Myopia (nearsightedness) and hyperopia (farsightedness) develop through different molecular pathways, according to a new study publishing October 9 in the open-access journal PLOS Biology by Andrei Tkatchenko of Columbia University and colleagues.

10 Oct 2018

Scientists identify new biomarker for Alzheimer's disease of sporadic origin

The objective of the research, undertaken in the laboratories of the IBPM, is to develop a model for studying Alzheimer's disease of sporadic origin, in other words, not due to a hereditary genetic mutation.

10 Oct 2018

Scientists discover pheromone-sensing gene that predates land-dwelling vertebrates

Scientists at Tokyo Institute of Technology have discovered a gene that appears to play a vital role in pheromone sensing. The gene is conserved across fish and mammals and over 400 million years of vertebrate evolution, indicating that the pheromone sensing system is much more ancient than previously believed.

10 Oct 2018

Massively parallel single-nucleus RNA sequencing reveals insights into heart disease

Scientists using a powerful new technology that sequences RNA in 20,000 individual cell nuclei have uncovered new insights into biological events in heart disease.

9 Oct 2018

Researchers provide new knowledge about retrovirus-host coevolution

Retroviruses have colonized vertebrate hosts for millions of years by inserting their genes into host genomes, enabling their inheritance through generations as endogenous retroviruses.

8 Oct 2018

Researchers design new method to pinpoint genetic differences between species

Why do naked mole rats live up to 31 years, when distantly related lab mice are lucky to make it to four? How is the aquatic axolotl capable of regenerating limbs, jaws, spines and even brains when frogs can only regrow tails as tadpoles? How can these difference be exploited for the benefit of human health?

8 Oct 2018

Largest ever study identifies new genes linked with high blood pressure

The largest ever genetic analysis of over one million people has identified 535 new genes associated with high blood pressure.

8 Oct 2018

New genome editing tool used to heal genetic disease

Parents of newborns may be familiar with the metabolic disorder phenylketonuria: in Switzerland, all newborn babies are screened for this genetic disease.

8 Oct 2018

Identification of wheat resistance gene promotes durable solution for controlling food security threat

Identification of the wheat Yr15 resistance gene promotes a durable solution for controlling yellow rust, a major threat to food security for millions of people, believes an international research group led by Natural Resources Institute Finland, the Institute of Biotechnology at the University of Helsinki, and the University of Haifa.

8 Oct 2018

New epigenetic screening method could improve cancer detection

Researchers have found a better way to determine the epigenetic code of DNA for the identification of disease, using enzymes instead of bisulphite.

8 Oct 2018

Researchers use CRISPR-Cas9 to prevent congenital disease in utero

Researchers have successfully used prenatal gene editing (CRISPR-Cas9) to prevent a fatal metabolic disorder in an animal model.

8 Oct 2018

DFG publishes new position paper on synthetic biology

Scientific developments in the field of synthetic biology have often given rise to public debate on the possible need for additional regulation. In response, the Permanent Senate Commission on Genetic Research of the Deutsche Forschungsgemeinschaft has published a position paper on synthetic biology, in which it describes key scientific advancements in the field within the context of current public discourse.

8 Oct 2018

Study highlights opposite effects of gene following different types of environmental events

Researchers have discovered that the same gene which increases your risk of depression following financial stress as you grow older also reduces your chance of depression associated with friendship and relationships stresses when young- your social network.

8 Oct 2018

Gene signature can predict functional recovery after spinal cord injury

Scientists have determined a gene signature that is linked to the severity of spinal cord injury in animals and humans, according to a study in the open-access journal eLife.

5 Oct 2018

Study finds typical mutations in offspring of radar soldiers

The offspring of radar soldiers exposed to high doses of radiation during their service experience more genetic alterations than families without radiation exposure.

5 Oct 2018

New method for studying the cell nucleus could improve disease detection

Researchers at New York University have found a way to measure the physical properties of the nucleus and its constituents in live human cells.

5 Oct 2018

New DNA tool can predict people's height and potentially assess risk for serious illnesses

A new DNA tool created by Michigan State University can accurately predict people's height, and more importantly, could potentially assess their risk for serious illnesses, such as heart disease and cancer.

5 Oct 2018

Researchers decode regulatory impact on neuronal survival of small non-coding RNA molecule

An interdisciplinary and international research group led by Dr. Volker Busskamp from the Center for Regenerative Therapies Dresden at the TU Dresden has decoded the regulatory impact on neuronal survival of a small non-coding RNA molecule, so-called miRNA, at the highest resolution to date.

4 Oct 2018

Expert proposes new model to generate automated updates of genetic test results

Maybe the genetic test report your doctor ordered says your DNA contains many “variants of unknown significance.” Currently, up to 70 percent of such reports are negative or inconclusive.

4 Oct 2018

Blocking stress-responsive protein reduces loss of tumor suppressor gene in breast cancer

Over half of all breast cancers carry genetic defects in the p53 gene, a powerful tumor suppressor. Loss of this gene increases the risk of getting breast cancer and the resultant cancers become highly resistant to treatment.

4 Oct 2018

Genomics

Molecular pathways underlying myopia open new ways for drug development

Scientists identify new biomarker for Alzheimer's disease of sporadic origin

Scientists discover pheromone-sensing gene that predates land-dwelling vertebrates

Massively parallel single-nucleus RNA sequencing reveals insights into heart disease

Researchers provide new knowledge about retrovirus-host coevolution

Researchers design new method to pinpoint genetic differences between species

Largest ever study identifies new genes linked with high blood pressure

New genome editing tool used to heal genetic disease

Identification of wheat resistance gene promotes durable solution for controlling food security threat

New epigenetic screening method could improve cancer detection

Researchers use CRISPR-Cas9 to prevent congenital disease in utero

DFG publishes new position paper on synthetic biology

Study highlights opposite effects of gene following different types of environmental events

Gene signature can predict functional recovery after spinal cord injury

Study finds typical mutations in offspring of radar soldiers

New method for studying the cell nucleus could improve disease detection

New DNA tool can predict people's height and potentially assess risk for serious illnesses

Researchers decode regulatory impact on neuronal survival of small non-coding RNA molecule

Expert proposes new model to generate automated updates of genetic test results

Blocking stress-responsive protein reduces loss of tumor suppressor gene in breast cancer

Synthetic Biology and the Pursuit of Living Diagnostics

Modular, Scalable, Intelligent: How n6 Is Rethinking NGS Library Prep

Evolving spectrophotometry for modern biopharma workflows

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