Genomics

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Genetic variants mimicking IL-6 inhibition linked to lower cardiovascular risk

People with lower interleukin-6 activity have a reduced risk of cardiovascular diseases, a new LMU study reveals.

26 Aug 2025

Genetics and diet work together to shape daily rhythms of fat metabolism

Our bodies follow a natural 24-hour cycle known as the circadian rhythm that influences everything from sleep to metabolism.

25 Aug 2025

Next-gen sequencing reveals the regulatory potential of the non-coding genome

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark achievements of the Human Genome Project (HGP), scientists have increasingly focused on deciphering the non-coding regions of the human genome, which comprise approximately 98% of the genetic material.

23 Aug 2025

Epstein-Barr virus protein enhances cancer gene activity in HPV-positive cervical cells

A new research paper was published in Volume 16 of Genes & Cancer on August 6, 2025, titled "Epstein-Barr virus nuclear antigen 1 upregulates Derlin1 and PSMD10 expression in HeLa cells."

22 Aug 2025

Study reveals genome rewiring mechanism driving mantle cell lymphoma

Translocations are chromosomal "cut and paste" errors that drive many lymphomas, a type of blood cancer and the sixth most common form of cancer overall.

21 Aug 2025

Yale researchers uncover new RNA editing tools for safer genetic surgery

The ability to correct disease-causing genetic mistakes using genome editors holds great promise in medicine, but it is not without risk.

21 Aug 2025

New genome-wide CRISPR screening tool boosts natural killer cells to fight cancer

Natural killer (NK) cells became markedly better at killing cancer cells after scientists removed key gene targets identified through a new genome-wide CRISPR screening tool, according to new research from The University of Texas MD Anderson Cancer Center.

21 Aug 2025

New genetic study reveals why people age differently

It's a fact of life: Some people age better than others. Some ease into their 90s with mind and body intact, while others battle diabetes, Alzheimer's or mobility issues decades earlier.

20 Aug 2025

ChronODE method offers precision in timing gene therapy treatments

A Yale research team has created a new computer tool that can pinpoint when exactly genes turn on and off over time during brain development - a finding that may one day help doctors identify the optimal window to deploy gene therapy treatments.

20 Aug 2025

Fucosylation emerges as a key player in digestive inflammatory diseases and cancers

Fucosylation, a crucial post-translational modification, has emerged as a significant factor influencing digestive inflammatory diseases and cancers.

18 Aug 2025

FastUKB transforms UK Biobank research with seamless data extraction and analysis

FastUKB is an innovative tool specifically developed to streamline and enhance research workflows utilizing the UK Biobank, effectively addressing key limitations of existing platforms such as the UK Biobank Research Analysis Platform (RAP).

18 Aug 2025

New AAV gene therapy reverses age-related macular degeneration

Neovascular age-related macular degeneration (nAMD) is a progressive eye disease characterized by choroidal neovascularization and subretinal hemorrhage and exudation, leading to vision impairment. Current first-line treatment for nAMD are anti-VEGF agents, which has shown promising therapeutics outcomes.

18 Aug 2025

New generation of CRISPR shows safer path to treating genetic diseases

A new generation of CRISPR technology developed at UNSW Sydney offers a safer path to treating genetic diseases like Sickle Cell, while also proving beyond doubt that chemical tags on DNA - often thought to be little more than genetic cobwebs - actively silence genes.

17 Aug 2025

Engineered telomerase RNA offers temporary boost to telomere length in human stem cells

Much the way the caps on the ends of a shoelace prevent it from fraying, telomeres - regions of repetitive DNA sequences and a protein structure - protect the tips of chromosomes from damage.

14 Aug 2025

Origin-recognition complex plays a broad role in the regulation of gene expression

Origin-recognition complex, or ORC, plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports.

14 Aug 2025

Dual epigenetic marks found to regulate cell identity

Shedding light on what determines how cells become what they are meant to be-nerves, bone, muscles, etc.-can also help researchers understand how diseases develop when these biological programs break down.

14 Aug 2025

Gene editing restores hearing and balance in adult mice with DFNA41 deafness

Zheng-Yi Chen, DPhil, associate scientist at the Eaton-Peabody Laboratories, and Ines and Fredrick Yeatts Chair in Otolaryngology, at Mass Eye and Ear, is the senior and co-corresponding author of a paper published in the Journal of Clinical Investigation, "Single Dose Genome Editing Therapy Rescues Auditory and Vestibular Functions in Adult Mice with DFNA41 Deafness."

14 Aug 2025

Brain organoids reveal early changes in familial Alzheimer’s disease

Alzheimer's disease (AD) is the most common neurodegenerative disease in older people, affecting up to 1 in 20 individuals aged 65 and above. In addition to environmental and lifestyle factors, genetic mutations can predispose an individual to AD and some rare forms of inherited "familial" AD (fAD) are caused by known genetic mutations, with these affected individuals developing AD with high probability and at relatively young age.

14 Aug 2025

Camena Bioscience and Constructive Bio join synthetic biology collaboration to develop plant genomics

Camena Bioscience (Camena), an innovator in enzymatic DNA synthesis, and Constructive Bio (Constructive), a pioneer in whole genome writing, today announced they have joined a collaborative project led by the Max-Planck Institute of Molecular Plant Physiology (MPI-MP), Germany, for a research initiative to develop synthetic chloroplast genomes.

14 Aug 2025

New research sheds light on what makes the human brain unique

Research from scientists at University of California San Diego School of Medicine have shed new light on an age-old question: what makes the human brain unique?

13 Aug 2025

Genomics

Genetic variants mimicking IL-6 inhibition linked to lower cardiovascular risk

Genetics and diet work together to shape daily rhythms of fat metabolism

Next-gen sequencing reveals the regulatory potential of the non-coding genome

Epstein-Barr virus protein enhances cancer gene activity in HPV-positive cervical cells

Study reveals genome rewiring mechanism driving mantle cell lymphoma

Yale researchers uncover new RNA editing tools for safer genetic surgery

New genome-wide CRISPR screening tool boosts natural killer cells to fight cancer

New genetic study reveals why people age differently

ChronODE method offers precision in timing gene therapy treatments

Fucosylation emerges as a key player in digestive inflammatory diseases and cancers

FastUKB transforms UK Biobank research with seamless data extraction and analysis

New AAV gene therapy reverses age-related macular degeneration

New generation of CRISPR shows safer path to treating genetic diseases

Engineered telomerase RNA offers temporary boost to telomere length in human stem cells

Origin-recognition complex plays a broad role in the regulation of gene expression

Dual epigenetic marks found to regulate cell identity

Gene editing restores hearing and balance in adult mice with DFNA41 deafness

Brain organoids reveal early changes in familial Alzheimer’s disease

Camena Bioscience and Constructive Bio join synthetic biology collaboration to develop plant genomics

New research sheds light on what makes the human brain unique

The future of automation: Machine learning–driven hepatocyte and organoid counting

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

Reimagining light scattering for biotherapeutics

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