Genomics

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Genomic study reveals Babesia duncani's pathogenicity and virulence

'Tis the season for hiking now that spring has arrived and temperatures are on the upswing. But with hikes come insect bites and on the increase in North America is babesiosis, a malaria-like disease spread especially between May and October by a tick.

13 Apr 2023

Research reveals molecular features of rare mtDNA mutations

A high-throughput single-cell single-mitochondrial genome sequencing technology known as iMiGseq has provided new insights into mutations of mitochondrial DNA (mtDNA) and offers a platform for assessing mtDNA editing strategies and genetic diagnosis of embryos prior to their implantation.

13 Apr 2023

New tool provides insight into the developmental history of certain immune cells

A new tool that can uncover the developmental history of certain immune cells is now freely available worldwide. The tool provides insights into the stages that immune cells go through in a healthy individual and how this can be impacted in disease.

13 Apr 2023

From Sanger Sequencing to the Human Genome Project: The Evolution of DNA Sequencing Technology

In this inspiring interview, we speak to Dr. Radoje Drmanac, co-founder of Complete Genomics, about the past, present, and future of genomics research.

From MGI 13 Apr 2023

Study provides direct evidence of adaptive evolution in the skin microbiome

Human skin is home to millions of microbes. One of these microbes, Staphylococcus aureus, is an opportunistic pathogen that can invade patches of skin affected by eczema, also known as atopic dermatitis.

12 Apr 2023

Transcription of genes is fast but sloppy in old age

In a large joint project, a total of six research groups from the University of Cologne Cluster of Excellence on Cellular Stress Responses in Age-Associated Diseases (CECAD), the Max Planck Institute for Biology of Aging (MPI) in Cologne and the University of Göttingen have demonstrated the following findings which apply across the animal kingdom: with increasing age, the transcriptional elongation speed of genes increases, whereby the quality of the gene products suffers.

12 Apr 2023

Researchers conduct experiments comparing de novo proteins with computer-generated proteins

Proteins are components of every cell. How they have changed in the course of evolution for the purpose of taking on new functions in the body, has long been a subject of research.

12 Apr 2023

Optimized genome-editing method opens the door to more effective treatment of genetic diseases

CRISPR-Cas9 is widely used to edit the genome by studying genes of interest and modifying disease-associated genes.

11 Apr 2023

Exploring the tantalizing questions about sleep

Sleep is one of the most essential human activities - so essential, in fact, that if we don't get enough sleep for even one night, we may struggle to think, react, and otherwise make it through the day.

11 Apr 2023

Mutant Salmonella strains cause more severe infections than wild-type bacteria in chickens

In Brazil, a group of researchers supported by FAPESP created mutant forms of Salmonella to understand the mechanisms that favor colonization of the intestinal tract of chickens by these pathogenic bacteria and find better ways to combat the infection they cause.

11 Apr 2023

Study to measure the impact of whole genome sequencing in patients with cardiovascular disease

Henry Ford Health research teams are launching a series of clinical studies in partnership with Illumina Inc., a global leader in DNA sequencing and array-based technologies, to assess the impact of comprehensive genomic testing in various disease areas.

11 Apr 2023

Study expands the knowledge about gut viral diversity in healthy infants

Viruses are usually associated with illness. But our bodies are full of both bacteria and viruses that constantly proliferate and interact with each other in our gastrointestinal tract.

11 Apr 2023

Genetically-engineered probiotic could be a new way to reduce alcohol-induced health problems

Excessive alcohol consumption leads to painful hangovers and accompanying headaches, fatigue, and nausea.

11 Apr 2023

SARS-CoV-2 may exploit multiple receptors and pathways across various tissues, age groups

A study led by Mount Sinai researchers Dr. Bin Zhang, the Willard T.C. Johnson Research Professor of Neurogenetics, and Dr. Christian Forst, an Associate Professor in the Department of Genetics and Genomic Sciences, have identified potential novel receptors for SARS-CoV-2 and unveiled their tissue-specific and age-dependent expression.

11 Apr 2023

Urban light pollution may disrupt winter dormancy period for disease-carrying mosquitoes

A new study's finding that urban light pollution may disrupt the winter dormancy period for mosquitoes that transmit West Nile virus could be considered both good news and bad news.

10 Apr 2023

Using the gene-editing tool to model certain liver tumor subtypes

Mutations in our genes can lead to severe problems, like colon or liver cancer. But cancer is very complex.

10 Apr 2023

Genetic discovery may pave the way for precision medicine approaches to treat depression

A team of scientists at the Medical University of South Carolina (MUSC) has identified a stress-regulated gene that plays a role in the link between long-term stress and a common type of depressive behavior in mice.

7 Apr 2023

3D structure of a probable precursor to the CRISPR-Cas12 enzyme revealed

Gene editing is one of the latest breakthroughs in biology. The widely known CRISPR-Cas gene editing system provided prokaryotes (organisms that lack cell nuclei) an immunity against foreign DNA. Since the discovery of the CRISPR gene editing technology, scientists are revealing the evolution of the CRISPR-Cas proteins from their precursors.

7 Apr 2023

New method estimates mutation risks due to residual radiation from the Fukushima nuclear disaster

Ionizing radiation from nuclear disasters are known to be harmful to the natural environment. The Fukushima Dai-ichi Nuclear Power Plant meltdown that occurred in 2011 is a prominent example of such a disaster in recent memory.

7 Apr 2023

Virginia Tech to study the regulation of genes responsible for cannabinoid biosynthesis

Industrial cultivation of hemp is seeing a massive expansion in the United States due to new federal laws and consumer demand.

6 Apr 2023

Genomics

Genomic study reveals Babesia duncani's pathogenicity and virulence

Research reveals molecular features of rare mtDNA mutations

New tool provides insight into the developmental history of certain immune cells

From Sanger Sequencing to the Human Genome Project: The Evolution of DNA Sequencing Technology

Study provides direct evidence of adaptive evolution in the skin microbiome

Transcription of genes is fast but sloppy in old age

Researchers conduct experiments comparing de novo proteins with computer-generated proteins

Optimized genome-editing method opens the door to more effective treatment of genetic diseases

Exploring the tantalizing questions about sleep

Mutant Salmonella strains cause more severe infections than wild-type bacteria in chickens

Study to measure the impact of whole genome sequencing in patients with cardiovascular disease

Study expands the knowledge about gut viral diversity in healthy infants

Genetically-engineered probiotic could be a new way to reduce alcohol-induced health problems

SARS-CoV-2 may exploit multiple receptors and pathways across various tissues, age groups

Urban light pollution may disrupt winter dormancy period for disease-carrying mosquitoes

Using the gene-editing tool to model certain liver tumor subtypes

Genetic discovery may pave the way for precision medicine approaches to treat depression

3D structure of a probable precursor to the CRISPR-Cas12 enzyme revealed

New method estimates mutation risks due to residual radiation from the Fukushima nuclear disaster

Virginia Tech to study the regulation of genes responsible for cannabinoid biosynthesis

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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