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Researchers develop broad-spectrum SARS-CoV-2 RBD-based vaccine

In a recent bioRxiv* preprint, the large team of researchers evaluated a SARS-CoV-2 Spike receptor-binding domain ferritin nanoparticle protein vaccine (RFN) in a nonhuman primate challenge model. This study addresses the need for a next-generation, efficacious vaccine with an increased pan-SARS breadth of coverage.

13 Apr 2021

Researchers identify SARS-CoV-2 antiviral compounds using protein assay

During the process of SARS-CoV-2 infection, once the virus penetrates the host cell, two open reading frames, ORF1a and ORF1ab, are translated. ORF1ab is responsible for the production of 16 nonstructural proteins (nsp). Several viral proteases such as 3CLpro and PLpro (papain-like protease) produce 1-16 nsps. A new study has been published in bioRxiv* preprint server, which deals with identifying drugs that are effective as PLpro inhibitors.

13 Apr 2021

People who experience big dips in blood sugar levels consume more calories

New research shows that people who experience big dips in blood sugar levels, several hours after eating, end up feeling hungrier and consuming hundreds more calories during the day than others.

13 Apr 2021

Comprehensive medication management delivered by pharmacists supports primary care

Evidence is growing that health care delivered by teams is superior to services delivered by a single practitioner.

13 Apr 2021

Pandemic has triggered changes in mental health and physical activity

New research from McMaster University suggests the pandemic has created a paradox where mental health has become both a motivator for and a barrier to physical activity.

13 Apr 2021

Experts review new studies on cardiovascular effects of cigarette smoking versus electronic cigarettes

Electronic cigarette (EC) use, or vaping, has both gained incredible popularity and generated tremendous controversy, but although they may be less harmful than tobacco cigarettes (TCs), they have major potential risks that may be underestimated by health authorities, the public, and medical professionals.

13 Apr 2021

CityMD experience during the coronavirus pandemic in New York City

Limiting SARS-CoV-2 transmission requires an infected person to quarantine themselves for at least two weeks. New research published on the medRxiv* server highlights the vital role urgent care centers play during the COVID-19 pandemic in New York.

13 Apr 2021

Americans are consuming poor nutritional quality food everywhere, except at school

Whether eating out or buying food from the grocery store, Americans of all ages are, for the most part, eating poorly everywhere - except at school.

13 Apr 2021

Study finds correlation between COVID-19 pandemic and six unhealthy eating behaviors

A new probe into the lingering impacts of the COVID-19 pandemic revealed correlations to six unhealthy eating behaviors, according to a study by the University of Minnesota Medical School and School of Public Health.

12 Apr 2021

Residents in majority-Black neighborhoods experience higher rates of severe maternal morbidity

Residents in majority-Black neighborhoods experience higher rates of severe pregnancy-related health problems than those living in predominantly-white areas, according to a new study of pregnancies at a Philadelphia-based health system, which was led by researchers in the Perelman School of Medicine at the University of Pennsylvania.

12 Apr 2021

Recreational runners face a higher risk of injury

Almost half of all recreational runners incur injuries, mostly relating to knees, calves or Achilles tendons, and the level of risk is equally high whatever your age, gender or running experience. These are the findings of a thesis within sport science.

12 Apr 2021

Research reveals the impact of COVID‐19 pandemic on families' well-being and functioning

When the COVID-19 pandemic hit in early 2020, many families found themselves suddenly isolated together at home. A year later, new research has linked this period with a variety of large, detrimental effects on individuals' and families' well-being and functioning.

12 Apr 2021

Study identifies a 'window of impairment' caused by cannabis intoxication

A comprehensive analysis of 80 scientific studies has identified a 'window of impairment' of between three and 10 hours caused by moderate to high doses of the intoxicating component of cannabis, tetrahydrocannabinol (THC).

12 Apr 2021

Adult survivors of AYA cancers more likely to experience higher medical financial hardship

New study finds higher medical financial hardship in adult survivors of adolescent and young adult (AYA) cancers than in adults without a history of cancer in the United States.

12 Apr 2021

Broadly cross-reactive antibody to SARS-CoV-2 RBD with robust resistance to mutational escape

A new study addresses an urgent need – namely, a therapeutic antibody directed specifically against a key SARS-CoV-2 antigen which is highly conserved among similar viruses, and is not easily bypassed by viral escape mutations.

12 Apr 2021

Small molecule inhibitors of SARS-CoV-2 identified by screening

A new study describes the identification of small molecule inhibitors that block the catalytic activity of the crucial viral non-structural protein 5 (nsp5), using a large-scale screening method.

12 Apr 2021

P681 mutation has little impact on transmissibility in the SARS-CoV-2 UK variant, finds study

A new preprint, recently released on the bioRxiv* server, explores the impact of a single mutation, the P681H mutation, on the transmissibility of the virus.

12 Apr 2021

Current hygiene guidelines appropriate for UK and SA variants of SARS-CoV-2, study finds

Many different variants and lineages have arisen from the ancestral Wuhan-Hu1 strain of the SARS-CoV-2. This requires careful attention to control measures since many are more infective and transmissible than the older strains. A recent study compares the UK variant of this virus with the wildtype in terms of susceptibility to routine cleaning and disinfection measures.

12 Apr 2021

Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells

A team of scientists from the United Kingdom recently investigated the ultrastructural details of the attachment, entry, and budding processes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human airway epithelium. They have used a highly differentiated air-liquid interface cultures of airway epithelium to thoroughly investigate the viral infection cycle. The study is currently available on the bioRxiv* preprint server.

12 Apr 2021

Researchers explore an inhalable SARS-CoV-2 nanobody therapy

Even as vaccines against SARS-CoV-2 are being developed and administered at an unprecedented pace, treating this infection remains a challenge. To address this, researchers from China have used nanobodies (Nb) as a possible therapeutic approach. They reported Nb phage display libraries derived from four camels immunized with the SARS-CoV-2 spike RBD.

12 Apr 2021

Healthcare News

Researchers develop broad-spectrum SARS-CoV-2 RBD-based vaccine

Researchers identify SARS-CoV-2 antiviral compounds using protein assay

People who experience big dips in blood sugar levels consume more calories

Comprehensive medication management delivered by pharmacists supports primary care

Pandemic has triggered changes in mental health and physical activity

Experts review new studies on cardiovascular effects of cigarette smoking versus electronic cigarettes

CityMD experience during the coronavirus pandemic in New York City

Americans are consuming poor nutritional quality food everywhere, except at school

Study finds correlation between COVID-19 pandemic and six unhealthy eating behaviors

Residents in majority-Black neighborhoods experience higher rates of severe maternal morbidity

Recreational runners face a higher risk of injury

Research reveals the impact of COVID‐19 pandemic on families' well-being and functioning

Study identifies a 'window of impairment' caused by cannabis intoxication

Adult survivors of AYA cancers more likely to experience higher medical financial hardship

Broadly cross-reactive antibody to SARS-CoV-2 RBD with robust resistance to mutational escape

Small molecule inhibitors of SARS-CoV-2 identified by screening

P681 mutation has little impact on transmissibility in the SARS-CoV-2 UK variant, finds study

Current hygiene guidelines appropriate for UK and SA variants of SARS-CoV-2, study finds

Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells

Researchers explore an inhalable SARS-CoV-2 nanobody therapy

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

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