Histology & Microscopy

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Multiscale model reveals the importance of lipids to the signaling dynamics of RAS proteins

Lawrence Livermore National Laboratory researchers and a multi-institutional team of scientists have developed a highly detailed, machine learning-backed multiscale model revealing the importance of lipids to the signaling dynamics of RAS, a family of proteins whose mutations are linked to numerous cancers.

10 Jan 2022

Intestinal organoids used to explain why bats infected with viruses do not succumb to diseases

Experiments attempting to explain why bats can be infected with many viruses at a time without succumbing to diseases such as COVID-19 - knowledge that could help us to reduce the threat to humans of infectious disease - have struggled until now with the fact that live wild bats make poor research subjects.

30 Dec 2021

New techniques enable visualization of DNA repair machinery in detail

Each one of the trillions of cells that make up the human body suffers more than 10,000 DNA lesions every day. These injuries would be catastrophic if cells were unable to repair them, but a very delicate machinery that detects and repair genetic damage is at work to prevent DNA mutations and diseases such as cancer.

29 Dec 2021

X-ray imaging of cardiac tissue reveals the impact of Covid-19 on the heart

An interdisciplinary research team from the University of Göttingen and Hannover Medical School (MHH) has detected significant changes in the heart muscle tissue of people who died from Covid-19.

23 Dec 2021

Researchers identify a key influenza epitope that can targeted for developing universal vaccines

A team led by scientists at Weill Cornell Medicine, Scripps Research and the University of Chicago has identified an important site of vulnerability on influenza viruses—a site that future influenza vaccines and antibody therapies should be able to target to prevent or treat infections by a broad set of influenza strains.

23 Dec 2021

Research reveals the structure and function of a bifunctional protein that transports heme

Heme is an essential part of the protein hemoglobin, which colors human blood red. Heme also is crucial for cytochrome proteins, which power the cell. Humans, animals, plants and bacteria all use heme.

21 Dec 2021

New tool provides an unprecedented view of brain cell activity in a synapse

To solve the mysteries of how learning and memory occur, Johns Hopkins Medicine scientists have created a system to track millions of connections among brain cells in mice — all at the same time — when the animals' whiskers are tweaked, an indicator for learning.

20 Dec 2021

Novel technique developed to observe cancer cells’ metastatic potential

When cancer cells metastasize, they morph, becoming missile-shaped in order to penetrate into other tissues throughout the body.

16 Dec 2021

$1.5 million award helps U-M researchers to gain new window into the inner workings of cells

The precise shapes of proteins at work inside our cells offer essential clues about the processes that drive health and disease. Structural biologists determine the forms of molecular machines, in atomic detail, to better understand how they function or what happens when they malfunction.

15 Dec 2021

Johns Hopkins astrophysicist receives Life Sciences 2021 award for novel cancer mapping technology

Johns Hopkins astrophysicist, Alexander Szalay, Ph.D., and Kimmel Cancer Center pathologist Janis Taube, M.D., M.Sc., received a Life Sciences 2021 award for AstroPath at this year's Falling Walls Science Summit, an international event honoring research breakthroughs from across the globe.

9 Dec 2021

Scientists determine structure of the molecule associated with ALS for the first time

Scientists have determined for the first time the structure of the molecule associated with amyotrophic lateral sclerosis (ALS) and multiple other neurodegenerative diseases.

9 Dec 2021

Study reveals how a protein in the blood is attracted to key component of Adenovirus-based vaccines

A collaborative team from the School of Medicine at the University of Cardiff, Wales and a range of US institutions used the UK's national synchrotron, Diamond Light Source, to help reveal the details of how a protein in the blood is attracted to a key component of Adenovirus based vaccines.

8 Dec 2021

Researchers discover mechanism for congenital disorders of glycosylation

Greenwood Genetic Center researchers are reporting the discovery of a mechanism that contributes to the tissue phenotypes seen in PMM2-CDG, the most common of the congenital disorders of glycosylation (CDGs).

8 Dec 2021

Using soft X-ray tomography for 3D imaging of cell structures in few minutes

Viral pathogens like the SARS-CoV-2 coronavirus change the interior structure of the cells they infect. These changes occur at the level of individual cell components – the organelles – and can provide information on how viral diseases develop.

6 Dec 2021

X-ray laser offers new insights into how radiation damage occurs in biological tissue

An international research team has used the X-ray laser European XFEL to gain new insights into how radiation damage occurs in biological tissue.

6 Dec 2021

Novel approach uses PSOCT to non-invasively image the depth-resolved collagen organization

Collagen is essential for tissue integrity and stability, and changes in its intrinsic organization are the key features in several important diseases such as scar formation, heart infarction and cancers.

29 Nov 2021

The mode of action of essential proteins involved in cancer and Alzheimer´s deciphered

The proteins that belong to the HAT family are essential for life as they transport amino acids across the cell membrane. Although the members of this family are practically identical, some transport certain amino acids and not others.

29 Nov 2021

New technique may be a significant leap forward in the understanding of human cells

Most human diseases can be traced to malfunctioning parts of a cell — a tumor is able to grow because a gene wasn't accurately translated into a particular protein or a metabolic disease arises because mitochondria aren't firing properly, for example. But to understand what parts of a cell can go wrong in a disease, scientists first need to have a complete list of parts.

24 Nov 2021

Novel method enables deeper analysis of endocrine disrupting chemicals' impact on gene expression

When something disrupts hormone binding to the receptor, such as environmental compounds or pollutants, called endocrine disrupting chemicals (EDCs), the results can be harmful and, in some cases, lead to certain forms of cancer.

24 Nov 2021

New "image analysis pipeline" provides insight into how disease changes the body

A new "image analysis pipeline" is giving scientists rapid new insight into how disease or injury have changed the body, down to the individual cell.

24 Nov 2021

Histology & Microscopy

Multiscale model reveals the importance of lipids to the signaling dynamics of RAS proteins

Intestinal organoids used to explain why bats infected with viruses do not succumb to diseases

New techniques enable visualization of DNA repair machinery in detail

X-ray imaging of cardiac tissue reveals the impact of Covid-19 on the heart

Researchers identify a key influenza epitope that can targeted for developing universal vaccines

Research reveals the structure and function of a bifunctional protein that transports heme

New tool provides an unprecedented view of brain cell activity in a synapse

Novel technique developed to observe cancer cells’ metastatic potential

$1.5 million award helps U-M researchers to gain new window into the inner workings of cells

Johns Hopkins astrophysicist receives Life Sciences 2021 award for novel cancer mapping technology

Scientists determine structure of the molecule associated with ALS for the first time

Study reveals how a protein in the blood is attracted to key component of Adenovirus-based vaccines

Researchers discover mechanism for congenital disorders of glycosylation

Using soft X-ray tomography for 3D imaging of cell structures in few minutes

X-ray laser offers new insights into how radiation damage occurs in biological tissue

Novel approach uses PSOCT to non-invasively image the depth-resolved collagen organization

The mode of action of essential proteins involved in cancer and Alzheimer´s deciphered

New technique may be a significant leap forward in the understanding of human cells

Novel method enables deeper analysis of endocrine disrupting chemicals' impact on gene expression

New "image analysis pipeline" provides insight into how disease changes the body

Fluidics in Modern Healthcare & Medical Device Innovation

Scaling 3D biology: Automation, imaging, and the future of high-throughput research

How does norepinephrine influence anxiety-related behaviours?

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