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ESMO releases updated scale to measure clinical benefit of cancer treatments

The European Society for Medical Oncology (ESMO) is pleased to announce the publication of the latest version of the scale that measures the clinical benefit of cancer treatments, the ESMO-MCBS (ESMO-Magnitude of Clinical Benefit Scale).

23 May 2025

Metagenomic next-generation sequencing improves pulmonary infection diagnosis

A recent study on the application of Metagenomic next-generation sequencing (mNGS) found that mNGS can achieve early detection of pathogens and accelerate the development of targeted anti-infection treatment plans, thereby improving treatment outcomes and patient prognosis.

23 May 2025

Long-term study confirms safety and effectiveness of rivaroxaban for children

Venous thromboembolism (VTE) is a life-threatening complication in children with serious underlying conditions such as heart defects or cancer.

23 May 2025

Muscle quality linked to cognitive health in middle age

Over the past decade, much research has focused on the connection between skeletal muscle health and cognitive disorders.

23 May 2025

Autophagy-based mechanism provides insight into Parkinson’s disease protein secretion

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells.

23 May 2025

Aging metabolism reduces effectiveness of CAR-T cell therapy

A Ludwig Cancer Research study has discovered that the metabolic decline that accompanies aging impairs the efficacy of CAR-T cell therapy, an immunotherapy in which T cells of the immune system are taken from patients, engineered to target cancer cells and reinfused into the same patients for treatment.

23 May 2025

NIH scientists pioneer new retinal grafting technique for dry age-related macular degeneration

National Institutes of Health (NIH) scientists have developed a new surgical technique for implanting multiple tissue grafts in the eye's retina.

23 May 2025

Experimental ALS drug shows unprecedented recovery in some patients

When Columbia neurologist and scientist Neil Shneider speaks to his ALS patients who volunteer for experimental therapies, he's unwaveringly honest.

23 May 2025

Powerful new toolkit targets vision loss in advanced retinal degeneration

Inherited retinal degenerations (IRDs) are a group of genetic disorders that lead to progressive vision loss as the light-sensing cells of the eye-the photoreceptors-die due to mutations in genes needed for their function and survival.

23 May 2025

FOXP4 gene variants reveal new genetic link to long COVID risk

Researchers have identified genetic variants in the FOXP4 gene that significantly increase the risk of developing long COVID, independently of COVID-19 severity. The study also reveals that ancestry, smoking, and other factors contribute to the complex genetics of long COVID.

23 May 2025

Air pollution’s chemical punch alters immune markers in pregnant women, study finds

Personal exposure to nitrogen dioxide and the oxidative potential of fine particulate matter (PM2.5), but not PM2.5 mass, influenced immune biomarker levels in pregnant women. These findings suggest that the chemical reactivity of air pollutants may play a key role in maternal and fetal immune health.

22 May 2025

Researchers prolong ketamine’s antidepressant benefits to two months

Roughly 10 percent of the U.S. population is afflicted with major depressive disorder at any given time, and up to 20 percent will exhibit MDD symptoms over their lifetimes.

22 May 2025

Global female infertility rates surge, hitting women in their late 30s hardest

Researchers analyzed global data from 1990 to 2021 and found that over 110 million women worldwide were affected by infertility, with a significant rise in age-standardized rates. The study highlights shifting trends, with the greatest burden among women aged 35–39, and projections showing further increases in age-standardized rates by 2050.

22 May 2025

Machine learning tool identifies metabolic clues in colorectal cancer

Scientists aiming to advance cancer diagnostics have developed a machine learning tool that is able to identify metabolism-related molecular profile differences between patients with colorectal cancer and healthy people.

22 May 2025

Exercise and diet advice misses the mark in improving heart health around the globe

A leading cardiovascular disease researcher from Simon Fraser University is ringing the alarm on universal recommendations intended to improve heart health around the globe.

22 May 2025

Confocal microscopy may help identify biomarkers for chemotherapy-induced neuropathy

A University of Arizona Comprehensive Cancer Center researcher received a $2.4 million National Cancer Institute grant to develop a noninvasive, confocal microscope to examine nerve endings of cancer patients with chemotherapy-induced peripheral neuropathy in the hopes of identifying potential biomarkers for the disease.

22 May 2025

Blood markers offer hope for early detection of teen depression

Using a novel lab method they developed, McGill University researchers have identified nine molecules in the blood that were elevated in teens diagnosed with depression.

22 May 2025

Integrating phytomedicine and nanotechnology in managing COVID-19 related heart disease

Acute coronary syndrome (ACS) in patients with SARS-CoV-2 infection represents a critical intersection of viral-induced inflammation and cardiovascular pathology.

22 May 2025

Wastewater monitoring offers new tool for cervical cancer prevention

Scientists in Uruguay have found genotypes of the Human Papillomavirus (HPV) linked to cervical cancer in urban wastewater, saying it could help inform disease prevention efforts.

22 May 2025

Cutting back on sugary drinks may protect men’s fertility, review finds

Regular consumption of sugar-sweetened beverages is associated with lower sperm count, motility, and increased DNA damage, potentially impairing male reproductive health. This narrative review highlights dose-response effects, mechanisms, and research gaps, calling for further studies on diverse populations.

22 May 2025