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Detailed structure of protein pair offers blueprint for new medicines

Walter and Eliza Hall Institute researchers have visualized for the first time how the protein SOCS1 'switches off' cell signaling to dampen immune responses and block cancer growth.

4 Jun 2018

Protein inhibitor drug found to be safe and effective in treating patients with acute myeloid leukemia

Ivosidenib, an experimental drug that inhibits a protein often mutated in several cancers has been shown to be safe, resulting in durable remissions, in a study of acute myeloid leukemia with relapsed or refractory disease.

4 Jun 2018

MicroRNAs may hold key to predict how someone is affected by sleep loss

The key to predicting how someone is affected by sleep loss may be found in microRNAs, according to a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

4 Jun 2018

Patients taking aspirin before and after CABG surgery show reduced mortality risk

New research presented at this year's Euroanaesthesia congress in Copenhagen, Denmark shows that in patients undergoing a coronary artery bypass graft surgery, taking aspirin before and after surgery is associated with an 18% to 34% reduced mortality risk after 4 years.

4 Jun 2018

Free-floating DNA analysis test may help detect early-stage lung cancer

A test that analyzes free-floating DNA in the blood may be able to detect early-stage lung cancer, a preliminary report from the ongoing Circulating Cell-Free Genome Atlas study suggests.

4 Jun 2018

Poor sleep linked to junk food cravings, nighttime snacking, obesity, and diabetes

Nighttime snacking and junk food cravings may contribute to unhealthy eating behaviors and represent a potential link between poor sleep and obesity, according to a study by University of Arizona Health Sciences sleep researchers.

1 Jun 2018

Phase I trial shows safety of investigational drug in treating chronic lymphocytic leukemia

Reporting results from a first-in-human phase I clinical trial, researchers at University of California San Diego School of Medicine have found that treatment with cirmtuzumab, an experimental monoclonal antibody-based drug, measurably inhibited the "stemness" of chronic leukemia cancer cells - their ability to self-renew and resist terminal differentiation and senescence.

1 Jun 2018

Opdivo plus low-dose Yervoy shows promising results in treating renal cell carcinoma patients

Bristol-Myers Squibb Company today announced patient-reported outcomes data from the Phase 3 CheckMate -214 trial in intermediate- and poor-risk patients with advanced renal cell carcinoma treated with the Immuno-Oncology combination Opdivo plus low-dose Yervoy versus sunitinib over a two-year follow-up period.

1 Jun 2018

MD Anderson and Amgen collaborate to accelerate early-stage oncology therapies

The University of Texas MD Anderson Cancer Center and Amgen today announced two multi-year collaboration agreements aimed at accelerating development of a variety of Amgen's early-stage oncology therapies for patients with leukemia, myelodysplastic syndromes, multiple myeloma, small-cell lung cancer, and other non-lung cancers with small-cell histologies.

1 Jun 2018

Scientists discuss how common ecological models can improve gut health

When disturbances upset the balance of a forest, field, or stream, ecologists practice ecological restoration to assist ecosystem recovery.

1 Jun 2018

ORNL increases production of actinium-227 to meet demand for cancer drug

The Department of Energy's Oak Ridge National Laboratory is now producing actinium-227 (Ac-227) to meet projected demand for a highly effective cancer drug through a 10-year contract between the U.S. DOE Isotope Program and Bayer.

1 Jun 2018

Domestic violence’s overlooked damage: Concussion and brain injury

Hundreds of survivors of domestic violence have come through the doors of neurologist Glynnis Zieman’s Phoenix clinic in the past three years.

1 Jun 2018

New ACS guidelines recommend early screening for colorectal cancer

New guidelines developed by the American Cancer Society recommend that screening for colorectal cancer for average-risk adults begin at age 45, five years earlier than the previous recommendation.

1 Jun 2018

Regular mental health checkups may be better way to treat anxiety

No matter which treatment they get, only 20 percent of young people diagnosed with anxiety will stay well over the long term, UConn Health researchers report in the Journal of the American Academy of Child and Adolescent Psychiatry.

1 Jun 2018

Researchers reveal role NAD+ molecule in turning on genes that make fat cells

Glucose is the energy that fuels cells, and the body likes to store glucose for later use. But too much glucose can contribute to obesity, and scientists have long wanted to understand what happens within a cell to tip the balance.

1 Jun 2018

Cancer cells can use lipid molecules as fuel for growth, shows study

Cancer cells can when the blood supply is low use lipid molecules as fuel instead of blood glucose. This has been shown in animal tumor models by researchers at Karolinska Institutet in Sweden in a study published in Cell Metabolism.

1 Jun 2018

Researchers study effects of specific gut enterobacterium on body fat mass

A research project performed at the universities of Jyväskylä and Turku studied the effects of a specific gut enterobacterium on body fat mass.

1 Jun 2018

Study reveals 133 genetic variants that may improve risk prediction for glaucoma

Researchers funded by the National Eye Institute have identified 133 genetic variants that predict with 75-percent accuracy a person's risk for developing glaucoma related to elevated pressure within the eye.

31 May 2018

Study highlights complexity of the brain’s molecular response to cocaine use

A study in Biological Psychiatry has identified unique genetic changes in the brain's reward circuitry that are associated with cocaine use, including first-time use, withdrawal, and re-exposure to the drug after prolonged withdrawal.

31 May 2018

Study could open up new treatment approaches for neurodegenerative diseases

Cell biologists have deepened understanding of proteins associated with neurodegenerative diseases. The findings could open up new treatment approaches for disorders including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS), among others.

31 May 2018