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New study raises safety concerns on clinical use of caspase inhibitors for liver diseases

Many acute and chronic liver diseases, including alcoholic hepatitis, result from apoptotic (programmed) cell death mediated by the enzyme caspase. Caspase inhibitors have therapeutic potential to treat and prevent apoptosis-mediated liver injury, and some are currently in clinical trials.

9 Sep 2016

X-rays can be effective diagnostic tool for screening knee pain in patients older than 40

Knee pain is common among Americans age 40 and up. Nearly 1 in 17 people visit doctors' offices each year for knee pain or injuries from osteoarthritis--a progressive "wear and tear" disease of the joints.

9 Sep 2016

Novel controlled clinical trial finds Ayurvedic-based well-being program can alter blood-based metabolites

In a novel controlled clinical trial, participants in a six-day Ayurvedic-based well-being program that featured a vegetarian diet, meditation, yoga and massages experienced measurable decreases in a set of blood-based metabolites associated with inflammation, cardiovascular disease risk and cholesterol regulation.

9 Sep 2016

Penn researchers develop open-source software to infer evolutionary track of tumor metastasis

Individual cells within a tumor are not all the same. This may sound like a modern medical truism, but it wasn't very long ago that oncologists assumed that taking a single biopsy from a patient's tumor would be an accurate reflection of the physiological and genetic make-up of the entire mass.

9 Sep 2016

Study opens door to new class of therapies for Ras-dependent cancers

New research from The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai identifies a protein that may be an unexplored target to develop new cancer therapies.

9 Sep 2016

Research offers new insights into underlying mechanisms of deadly cystic fibrosis

A minor hiccup in the sequence of a human gene can have devastating impacts on health. Such flaws cause cystic fibrosis (CF), a disease affecting the lungs and other vital organs, often leading to death by the age of 30.

9 Sep 2016

New treatment reduces activity of Huntington's disease gene for several months in mice

A single injection of a new treatment has reduced the activity of the gene responsible for Huntington's disease for several months in a trial in mice.

9 Sep 2016

Study finds post-9/11 deterioration of mental health far beyond US borders

This is the conclusion of a recent population-wide study from Denmark, which demonstrates a "significant and immediate" spike in the diagnoses of trauma and stressor related disorders (e.g. adjustment disorders or post-traumatic stress disorder) in Denmark in the weeks and months after the traumatic events of September 11, 2001, even though the Nordic country was not directly impacted by the attacks.

9 Sep 2016

Researchers find no increase in cancer risk among WTC-exposed firefighters

Researchers found no overall increase in cancer risk among World Trade Center (WTC)-exposed firefighters following the 9/11 attacks compared with other firefighters from several US cities.

9 Sep 2016

New research could pave way for safe, effective treatment for muscular dystrophy

New research has shown that the corticosteroid deflazacort is a safe and effective treatment for Duchenne muscular dystrophy. The findings, which appear this month in the journal Neurology, could pave the way for first U.S.-approved treatment for the disease.

9 Sep 2016

UAB researchers find microRNA as potential therapeutic target for MDD

A tiny RNA appears to play a role in producing major depression, the mental disorder that affects as many as 250 million people a year worldwide.

9 Sep 2016

Liquid biopsies may be effective option for detecting mutations in advanced lung cancer patients

For patients with advanced lung cancer, a non-invasive liquid biopsy may be a more effective and suitable alternative to the gold standard tissue biopsy to detect clinically relevant mutations and help guide their course of treatment, suggests a new study published this week in the journal Clinical Cancer Research from researchers at the Abramson Cancer Center at the University of Pennsylvania.

9 Sep 2016

UTHealth receives DOD award to investigate stem cell therapy in adults with TBI

A research team led by Charles S. Cox, Jr., M.D., at The University of Texas Health Science Center at Houston has been awarded $6.8 million from the U.S. Department of Defense to assess the safety and efficacy of using autologous stem cell therapy in adults with emergent traumatic brain injury.

9 Sep 2016

Virginia Mason offers totally laparoscopic advanced surgery for removing tumors from pancreas

Virginia Mason now offers the totally laparoscopic Whipple procedure as an advanced surgical option for removing tumors from the head of the pancreas.

9 Sep 2016

Triptolide molecule can turn into 'cruise missile' against cancer

More than 20 years ago, a billboard in China piqued the interest of a chemical biologist. It endorsed an extract from the plant known as the “thunder god vine” as an immunosuppressant.

9 Sep 2016

New study pinpoints individual neurons in the brain that support observational learning

Picture a little boy imitating his father shaving in the mirror or a little girl wobbling proudly in her mother's high heels.

9 Sep 2016

Viral vector-based approaches could improve effectiveness of CFTR gene therapy

Cystic fibrosis (CF) is characterized by accumulation of thick mucus in the lungs and is associated with a high incidence of bacterial infection. Mutations in the gene encoding CF transmembrane conductance regulator (CFTR) underlie the disease.

9 Sep 2016

Right dose of CAR T cells and lymphodepletion can achieve good response rates for NHL patients

In a paper published today in Science Translational Medicine, researchers from Fred Hutchinson Cancer Research Center shared data from an early-phase study of patients with advanced non-Hodgkin lymphoma (NHL) who received JCAR014, a Chimeric Antigen Receptor (CAR) T cell treatment, and chemotherapy.

9 Sep 2016

Scientists discover potential new genetic causes for intellectual disability

An international group of researchers has for the first time identified a set of 30 inherited recessive genes that play a role in intellectual disability (ID), a neurodevelopmental disorder that, according to the Centers for Disease Control, affects as many as 213 million people around the world.

9 Sep 2016

Moderately vigorous physical activity in midlife linked to better cognition at old age

A new study of 3050 twins finds moderately vigorous physical activity - i.e., more strenuous than walking - to be associated with better cognition in a 25-year follow-up.

9 Sep 2016

Medical Condition News

New study raises safety concerns on clinical use of caspase inhibitors for liver diseases

X-rays can be effective diagnostic tool for screening knee pain in patients older than 40

Novel controlled clinical trial finds Ayurvedic-based well-being program can alter blood-based metabolites

Penn researchers develop open-source software to infer evolutionary track of tumor metastasis

Study opens door to new class of therapies for Ras-dependent cancers

Research offers new insights into underlying mechanisms of deadly cystic fibrosis

New treatment reduces activity of Huntington's disease gene for several months in mice

Study finds post-9/11 deterioration of mental health far beyond US borders

Researchers find no increase in cancer risk among WTC-exposed firefighters

New research could pave way for safe, effective treatment for muscular dystrophy

UAB researchers find microRNA as potential therapeutic target for MDD

Liquid biopsies may be effective option for detecting mutations in advanced lung cancer patients

UTHealth receives DOD award to investigate stem cell therapy in adults with TBI

Virginia Mason offers totally laparoscopic advanced surgery for removing tumors from pancreas

Triptolide molecule can turn into 'cruise missile' against cancer

New study pinpoints individual neurons in the brain that support observational learning

Viral vector-based approaches could improve effectiveness of CFTR gene therapy

Right dose of CAR T cells and lymphodepletion can achieve good response rates for NHL patients

Scientists discover potential new genetic causes for intellectual disability

Moderately vigorous physical activity in midlife linked to better cognition at old age

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

A new method to measure intracellular water in biological systems

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