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Nonprofits partner to raise awareness of scleroderma

If you've ever silently questioned someone wearing mittens on a warm spring day, the answer may be scleroderma. Or wondered why a woman, who otherwise appeared middle-aged, wore a face as wrinkle-free as her teenage daughter. The answer may be scleroderma.

2 Jun 2016

FDA approves blood-based cobas EGFR Mutation Test v2 for NSCLC patients

The U.S. Food and Drug Administration today approved the cobas EGFR Mutation Test v2, a blood-based companion diagnostic for the cancer drug Tarceva (erlotinib). This is the first FDA-approved, blood-based genetic test that can detect epidermal growth factor receptor (EGFR) gene mutations in non-small cell lung cancer patients.

2 Jun 2016

Infection may trigger development of Alzheimer's disease

A growing body of research on Alzheimer's disease suggests an infectious trigger for the development of the disease. According to Brian Balin, PhD, professor of pathology and chair of bio-medical sciences at Philadelphia College of Osteopathic Medicine, this could be the key to stopping the destructive process of Alzheimer's before it even starts.

2 Jun 2016

Excess phosphates in foods may lead to abnormally high blood pressure

Excess consumption of phosphate over-activates nerves that raise blood pressure, leading to abnormally high blood pressure, a new study in the American Journal of Physiology—Regulatory, Integrative and Comparative Physiology reports.

2 Jun 2016

New IRAP inhibitors may hold promise for improving cognitive functions in animal models

Researchers have discovered three new inhibitors of insulin-regulated aminopeptidase (IRAP), compounds shown to improve cognitive functions in animal models of human disorders.

2 Jun 2016

Correcting defective p73 gene function may be promising therapeutic strategy for chronic lung diseases

Rising global air pollution and increasing smoking prevalence in many developing nations will likely lead to a growing incidence of lung diseases such as chronic obstructive pulmonary disease (COPD), which currently affects more than 330 million people worldwide, is the third-leading cause of death and carries an estimated healthcare cost of $2.1 trillion.

2 Jun 2016

Multiple cell and gene therapies can enhance cardiac function in mice modeled with MI

Researchers at the University of Utah compared the therapeutic potential of umbilical cord-derived sub-epithelial cells (UC-SECs), bone marrow-derived mesenchymal stem cells (BM-MSCs) and induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) -- all derived from human tissue -- along with genes (S100a1 and SDF-1a) and growth factor (VEGF165) to evaluate how injected biologics might enhance cardiac function in mice modeled with myocardial infarction (MI; commonly referred to as heart attack).

2 Jun 2016

$CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory$

CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory

A two-year, multi-center clinical study with 167 patients with class III-IV refractory angina randomized to low and high dose CD34+ cells or placebo has revealed that patients who received either a high or low dose of CD34 -- a member of a family of proteins that have an impact on vascular-associated tissue -- cells had a significant reduction in angina frequency over patients who received placebo.

2 Jun 2016

Experts urge cancer researchers to use old, obese mice for preclinical immunotherapy studies

Researchers should include laboratory mice that are old and obese in their studies of immunotherapy treatments for cancer, according to a review article by Saint Louis University scientists.

2 Jun 2016

Buck researchers identify new, potential drug targets for sporadic PD

Research at the Buck Institute shows the same mechanisms that lead to neuronal cell death in mice genetically fated to develop Parkinson's disease (PD) are involved in the much more common sporadic form of the age-related, neurodegenerative disorder that robs people of the ability to move normally.

2 Jun 2016

Using proteomic mass spectrometry imaging to detect malignant melanoma: an interview with Stephen Turner

Today, using anatomic pathology, the differences in appearance of a normal or a malignant lesion can be difficult to tell when just using light microscopy.

2 Jun 2016

New research reveals functioning of brain's cleaning up mechanisms in neurodegenerative diseases

A piece of research led by the Achucarro Basque Center for Neuroscience, the University of the Basque Country, and the Ikerbasque Foundation has revealed how the brain's cleaning up mechanisms function in neurodegenerative diseases.

1 Jun 2016

New roadmap can help guide researchers to speed up biomarker-based research on Alzheimer's disease

Biomarkers could revolutionise the early detection of and therapy for Alzheimer's disease. However, experts attending the Congress of the European Academy of Neurology in Copenhagen criticized that the big breakthroughs are slow in coming because of a lack of priorities in research.

1 Jun 2016

Duke scientists discover new small-molecule drugs to treat chronic pain

A research team at Duke University has discovered a potential new class of small-molecule drugs that simultaneously block two sought-after targets in the treatment of pain.

1 Jun 2016

Vocal learning in songbirds sheds more light on developmental disorders in humans

Adult songbirds modify their vocalizations when singing to juveniles in the same way that humans alter their speech when talking to babies. The resulting brain activity in young birds could shed light on speech learning and certain developmental disorders in humans, according to a study by McGill University researchers.

1 Jun 2016

Brain scan combined with long-term memory test could help early Alzheimer's diagnosis

People with Alzheimer's disease could benefit from earlier diagnosis if a long-term memory test combined with a brain scan were carried out, a study suggests.

1 Jun 2016

Women less likely to receive good anticoagulant therapy for AF-related stroke, say researchers

Female atrial fibrillation patients are less likely than their male counterparts to receive blood thinning therapies to prevent stroke, say University of Cincinnati College of Medicine researchers.

1 Jun 2016

Toxic substance acrolein may play role in preventing fibrillation linked to Alzheimer's disease

Scientists from RIKEN in Japan have discovered that acrolein—a toxic substance produced in cells during times of oxidative stress—in fact may play a role in preventing the process of fibrillation, an abnormal clumping of peptides that has been associated with Alzheimer's disease and other neural diseases.

1 Jun 2016

Readmission rates after major cancer procedures depend on patient cohort, hospital characteristics

Readmission rates after complex cancer operations tend to be higher in hospitals that are considered to be vulnerable because they serve as safety nets in their communities or have a high number of Medicaid patients.

1 Jun 2016

Review sheds new light on link between smoking habits and psoriasis

Psoriasis: Targets and Therapy has published the review "Psoriasis and smoking: links and risks". As corresponding author Professor Luigi Naldi says "The review in Psoriasis: Targets and Therapy throws new light on the relation between smoking habits and psoriasis.

1 Jun 2016

Medical Condition News

Nonprofits partner to raise awareness of scleroderma

FDA approves blood-based cobas EGFR Mutation Test v2 for NSCLC patients

Infection may trigger development of Alzheimer's disease

Excess phosphates in foods may lead to abnormally high blood pressure

New IRAP inhibitors may hold promise for improving cognitive functions in animal models

Correcting defective p73 gene function may be promising therapeutic strategy for chronic lung diseases

Multiple cell and gene therapies can enhance cardiac function in mice modeled with MI

CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory

Experts urge cancer researchers to use old, obese mice for preclinical immunotherapy studies

Buck researchers identify new, potential drug targets for sporadic PD

Using proteomic mass spectrometry imaging to detect malignant melanoma: an interview with Stephen Turner

New research reveals functioning of brain's cleaning up mechanisms in neurodegenerative diseases

New roadmap can help guide researchers to speed up biomarker-based research on Alzheimer's disease

Duke scientists discover new small-molecule drugs to treat chronic pain

Vocal learning in songbirds sheds more light on developmental disorders in humans

Brain scan combined with long-term memory test could help early Alzheimer's diagnosis

Women less likely to receive good anticoagulant therapy for AF-related stroke, say researchers

Toxic substance acrolein may play role in preventing fibrillation linked to Alzheimer's disease

Readmission rates after major cancer procedures depend on patient cohort, hospital characteristics

Review sheds new light on link between smoking habits and psoriasis

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

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