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Key method to test compounds for anti-cancer activity in cells flawed, study reveals

The primary method used to test compounds for anti-cancer activity in cells is flawed, Vanderbilt University researchers report May 2 in Nature Methods. The findings cast doubt on methods used by the entire scientific enterprise and pharmaceutical industry to discover new cancer drugs.

3 May 2016

NEI-funded study analyzes outcomes of anti-VEGF therapy for AMD

In a study of nearly 650 people with the eye disease age-related macular degeneration (AMD), half still had vision 20/40 or better, typically good enough to drive or to read standard print, after five years of treatment with anti-VEGF drugs that are injected into the eye. The authors of the study, funded by the National Eye Institute (NEI) at the National Institutes of Health, say those outcomes would have been unimaginable about 10 years ago, prior to the drugs' availability.

3 May 2016

NEI to discuss research advances in regenerative medicine for eye disease at ARVO 2016

The National Eye Institute (NEI), part of NIH, is participating in the Inaugural Press Conference from the Association for Research in Vision and Ophthalmology Annual Meeting (ARVO 2016), the largest gathering of eye and vision researchers in the world, attracting over 11,000 attendees from more than 75 countries.

2 May 2016

Vernakalant drug more effective than Ibutilide in treating recent-onset atrial fibrillation

Vernakalant, a new drug for treating recent-onset atrial fibrillation, has proved to be considerably more effective than Ibutilide, an established drug in this indication. It was able to normalize patients' heart rhythm more rapidly and with fewer side-effects ocurring. This was revealed by a study conducted at the Department of Emergency Medicine at Medical University of Vienna/General Hospital that has recently been published in "Europace", a journal of the European Society of Cardiology.

2 May 2016

Addition of L19-IL2 can increase radiation therapy-induced immune response against tumours

Radiation therapy not only kills cancer cells, but also helps to activate the immune system against their future proliferation. However, this immune response is often not strong enough to be able to cure tumours, and even when it is, its effect is limited to the area that has been irradiated.

2 May 2016

Stereotactic body radiation therapy for NSCLC patients may raise non-cancer mortality risk

Researchers have found that treating patients who have early stage non-small cell lung cancer (NSCLC) with a type of radiotherapy called stereotactic body radiation therapy (SBRT) is associated with a small but increased risk of death from causes other than cancer.

2 May 2016

Rare germ cell tumor creates unique bond between two young women

Morgan Ellison and Madison McDaniel were diagnosed with a rare germ cell tumor of the ovary earlier this year. The two strangers would soon form a unique bond during their treatment in Birmingham, Alabama.

30 Apr 2016

Researchers one step closer to understanding disease origin

Researchers are one step closer to understanding the genetic and biological basis of diseases like cancer, diabetes, Alzheimer's and rheumatoid arthritis - and identifying new drug targets and therapies - thanks to work by three computational biology research teams from the University of Arizona Health Sciences, University of Pennsylvania and Vanderbilt University.

30 Apr 2016

Small doses of cancer drug may be potential treatment for sepsis and other pandemics

Results from laboratory experiments and mouse studies suggest that small doses of drugs from a specific class of approved cancer medications called topoisomerase 1 (top1) inhibitors may protect against the overwhelming immune response to infection that sometimes leads to sepsis, a bacterial condition that kills as many as 500,000 people in the United States each year.

30 Apr 2016

Novel gene therapy can treat pulmonary hypertension linked with heart failure

Scientists have used a novel gene therapy to halt the progression of pulmonary hypertension, a form of high blood pressure in the lung blood vessels that is linked to heart failure, according to a study led by Roger J. Hajjar, MD, Professor of Medicine and Director of the Cardiovascular Research Center at the Icahn School of Medicine at Mount Sinai.

30 Apr 2016

NBI-facilitated bladder tumour surgery can lower risk of cancer recurrence

Research into bladder tumour surgery has found that using narrow band imaging can significantly reduce the risk of disease recurrence.

30 Apr 2016

Scientists unveil reasons why NSAIDs, pain killers may increase heart disease risk

Researchers have known for more than a decade that the risk of heart disease and stroke increases when people take pain relievers like ibuprofen and other non-steroidal anti-inflammatory drugs, or NSAIDs. Now, scientists from the University of California, Davis, have uncovered some of the reasons why these drugs can harm heart tissue.

30 Apr 2016

Modified surgical technique may be effective treatment option for chronic temporal headache

A modified surgical technique may provide a simpler approach to the surgical treatment for one type of chronic headache, according to an "Ideas and Innovations" paper in the May issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons (ASPS).

30 Apr 2016

Researchers explore effects of adolescent obesity on cognitive performance in adulthood

The Franco-Mexican research explores the cognitive performance in adulthood when the subjects have been exposed to an obesogenic environment during adolescence.

30 Apr 2016

Level of salts in the brain play critical role in controlling sleep-wake cycle

Danish research is behind a new epoch-making discovery, which may prove decisive to future brain research. The level of salts in the brain plays a critical role in whether we are asleep or awake. This discovery may be of great importance to research on psychiatric diseases such as schizophrenia and convulsive fits from lack of sleep as well as post-anaesthetization confusion, according to Professor Maiken Nedergaard.

30 Apr 2016

NCCN publishes series of patient education materials for Non-Hodgkin's Lymphoma

It is estimated that more than 72,000 people in the United States will be diagnosed with Non-Hodgkin's Lymphomas (NHL) in 2016. The sixth leading cancer diagnosis in U.S. men and women, NHL has more than 30 sub-types, each featuring unique treatment choices and challenges.

30 Apr 2016

New article reviews ability of different stem cells to help restore function after spinal cord injuries

Stem cell therapy is a rapidly evolving and promising treatment for spinal-cord injuries. According to a new literature review, published in the April issue of the Journal of the American Academy of Orthopedic Surgeons, different types of stem cells vary in their ability to help restore function, and an ideal treatment protocol remains unclear pending further clinical research.

30 Apr 2016

Frailty, depression symptoms in older adults can affect spouses

Frailty, a condition that affects 10 percent of people aged 65 and older, can make older adults more prone to disability, falls, hospitalization and a shorter lifespan. Recently, researchers writing in the Journal of the American Geriatrics Society examined the effects of frailty and depression on married couples.

30 Apr 2016

Elusive brain receptor may play vital role in death of neurons from neurological diseases

Strokes, seizures, traumatic brain injury and schizophrenia: these conditions can cause persistent, widespread acidity around neurons in the brain. But exactly how that acidity affects brain function isn't well understood.

30 Apr 2016

Exposure to fine particulate matter in air can increase risk of cancer-specific mortality

In 2015, the International Agency for Research on Cancer (IARC) published a series of monographs on the evaluation of various carcinogenic risks. In a monograph on air pollution, the organization pointed out the difficulty of assessing the effects of pollution on multiple types of cancers, given their different etiologies, risk factors and variability in the composition of air pollutants in space and time. However, the IARC identified certain key components of air pollution, including particulates.

30 Apr 2016

Medical Condition News

Key method to test compounds for anti-cancer activity in cells flawed, study reveals

NEI-funded study analyzes outcomes of anti-VEGF therapy for AMD

NEI to discuss research advances in regenerative medicine for eye disease at ARVO 2016

Vernakalant drug more effective than Ibutilide in treating recent-onset atrial fibrillation

Addition of L19-IL2 can increase radiation therapy-induced immune response against tumours

Stereotactic body radiation therapy for NSCLC patients may raise non-cancer mortality risk

Rare germ cell tumor creates unique bond between two young women

Researchers one step closer to understanding disease origin

Small doses of cancer drug may be potential treatment for sepsis and other pandemics

Novel gene therapy can treat pulmonary hypertension linked with heart failure

NBI-facilitated bladder tumour surgery can lower risk of cancer recurrence

Scientists unveil reasons why NSAIDs, pain killers may increase heart disease risk

Modified surgical technique may be effective treatment option for chronic temporal headache

Researchers explore effects of adolescent obesity on cognitive performance in adulthood

Level of salts in the brain play critical role in controlling sleep-wake cycle

NCCN publishes series of patient education materials for Non-Hodgkin's Lymphoma

New article reviews ability of different stem cells to help restore function after spinal cord injuries

Frailty, depression symptoms in older adults can affect spouses

Elusive brain receptor may play vital role in death of neurons from neurological diseases

Exposure to fine particulate matter in air can increase risk of cancer-specific mortality

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

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