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Study on HDAC enzymes could lead to development of better drugs for treatment of cancer, Alzheimer’s

New knowledge about the mechanism of specific protein complexes in the body could help in the development of better drugs for the treatment of diseases such as cancer and Alzheimer’s, according to research led by the University of Leicester.

25 Apr 2016

Newly developed smartphone application may potentially benefit low-vision users

Researchers from the Schepens Eye Research Institute of Massachusetts Eye and Ear/Harvard Medical School have developed a smartphone application that projects a magnified smartphone screen to Google Glass, which users can navigate using head movements to view a corresponding portion of the magnified screen. They have shown that the technology can potentially benefit low-vision users, many of whom find the smartphone's built-in zoom feature to be difficult to use due to the loss of context. Their results are published online in the journal IEEE Transactions on Neural Systems and Rehabilitation Engineering.

25 Apr 2016

Bupropion, varenicline drugs do not increase risk of serious neuropsychiatric adverse events

Compared to the nicotine patch and a placebo, the smoking cessation aids varenicline (marketed as Chantix in the U.S.) and bupropion (Zyban) do not show a significant increase in neuropsychiatric adverse events, reports an international team of researchers in a study published online April 22 in the journal The Lancet.

25 Apr 2016

Mediterranean diet reduces risk of recurrent heart attacks or strokes

A "Mediterranean" diet, high in fruit, vegetables, fish and unrefined foods, is linked to a lower risk of heart attack and stroke in people who already have heart disease, according to a study of over 15,000 people in 39 countries around the world. The research also showed that eating greater amounts of healthy food was more important for these people than avoiding unhealthy foods, such as refined grains, sweets, desserts, sugared drinks and deep-fried food - a "Western" diet.

25 Apr 2016

Scientists derive first molecular model of critical transporter at blood-brain barrier

Scientists from Duke-NUS Medical School have derived a structural model of a transporter at the blood-brain barrier called Mfsd2a. This is the first molecular model of this critical transporter, and could prove important for the development of therapeutic agents that need to be delivered to the brain --- across the blood-brain barrier. In future, this could help treat neurological disorders such as glioblastoma.

25 Apr 2016

Type 2 diabetes can lead to hearing impairment

A review of studies of possible linkages between type 2 diabetes and hearing impairment concludes there is compelling evidence that diabetes can damage the auditory system, and that clinicians should include hearing testing in managing type 2 diabetes. The survey results were published in an article titled, "Type 2 Diabetes and Hearing Impairment" in the journal, Current Diabetes Reports.

25 Apr 2016

Fructose common in western diet can damage brain genes

A range of diseases -- from diabetes to cardiovascular disease, and from Alzheimer's disease to attention deficit hyperactivity disorder -- are linked to changes to genes in the brain. A new study by UCLA life scientists has found that hundreds of those genes can be damaged by fructose, a sugar that's common in the Western diet, in a way that could lead to those diseases.

25 Apr 2016

Study shows cancer cell death via necroptosis can drive pancreatic tumor growth

The most aggressive form of pancreatic cancer - often described as one of the hardest malignancies to diagnose and treat -- thrives in the presence of neighboring tumor cells undergoing a particular form of "orchestrated cell death." This is according to a major study recently published in the journal Nature.

25 Apr 2016

Why don’t MS patients always engage with specialists? An interview with Dr Anita Rose

The recent survey you ask about was conducted by the MS Trust in 2012. It revealed that nearly one fifth of respondents had seen neither an MS specialist nurse (MSSN) nor a neurologist in the past year, and so will not have received the comprehensive annual review recommended by the National Institute for Health and Care Excellence (NICE).

25 Apr 2016

Sleep loss influences cholesterol metabolism, study finds

Lack of sleep has previously been found to impact the activation of the immune system, inflammation, carbohydrate metabolism and the hormones that regulate appetite. Now University of Helsinki researchers have found that sleep loss also influences cholesterol metabolism.

22 Apr 2016

Cancer survivors at risk of death after organ transplant

People who had cancer before receiving an organ transplant were more likely to die of any cause, die of cancer or develop a new cancer than organ recipients who did not previously have cancer, a new paper has found. However, the increased risk is less than that reported in some previous studies.

22 Apr 2016

Under-expressed miR-9 gene may contribute to schizophrenia risk

By turning skin cells into brain neurons, researchers at the Icahn School of Medicine at Mount Sinai have identified that certain tiny molecules aiding in gene expression, known as microRNAs (miRNAs), are under-expressed in the brains of the 14 schizophrenia patients they studied. Their findings, published online today in the journal Cell Reports, show that one of these molecules, a miRNA known as miR-9, is a risk factor that controls the activity of hundreds of genes.

22 Apr 2016

Long way to go in better understanding brain abnormalities linked with autism

A recent review that examined all published studies on anatomical abnormalities in the brains of individuals with Autism Spectrum Disorder found substantial discrepancy throughout the literature regarding the reported presence and significance of neuroanatomical findings.

22 Apr 2016

Rituximab drug more effective than fingolimod for patients with highly active multiple sclerosis

A new study indicates that rituximab is more effective than fingolimod for preventing relapses in patients with highly active multiple sclerosis switching from treatment with natalizumab.

22 Apr 2016

3-D imaging of fibroblastic foci may help researchers study disease progression in IPF patients

Idiopathic pulmonary fibrosis (IPF) is a fatal disease in which progressive scarring of the lungs leads to respiratory failure. Lung scarring in IPF takes the form of aggregates of proliferating fibroblasts and myofibroblasts, known as "fibroblastic foci", which deposit collagen and other fibrotic components. These foci are thought to form in response to lung injury.

22 Apr 2016

Unmet nursing care may contribute to racial/ethnic differences in AMI readmissions

Why are black older adults at higher risk of repeat hospital admission after a heart attack? Treatment at hospitals with higher rates of missed nursing care may be a contributing factor, reports a study in the May issue of Medical Care.

22 Apr 2016

Unique mouse model could help study genetic origins and potential treatments for ALS

University of Florida Health researchers have developed a unique mouse model that will allow researchers around the world to better study the genetic origins and potential treatments for a neurodegenerative brain disease that causes amyotrophic lateral sclerosis, often referred to as ALS or Lou Gehrig's disease, and frontotemporal dementia.

22 Apr 2016

Rab inhibition may be a promising antimyeloma strategy

Roswell Park Cancer Institute researchers are investigating agents that target and disrupt the trafficking of monoclonal antibodies in multiple myeloma, a cancer of the bone marrow. The results will be presented at the American Association for Cancer Research Annual Meeting 2016, to be held April 16-20 in New Orleans.

22 Apr 2016

Wellderly study finds link between cognitive decline genes and healthy aging

An eight-year-long accrual and analysis of the whole genome sequences of healthy elderly people, or "Wellderly," has revealed a higher-than-normal presence of genetic variants offering protection from cognitive decline, researchers from the Scripps Translational Science Institute (STSI) reported today in the journal Cell.

22 Apr 2016

Higher levels of neighborhood greenness linked to lower chronic disease risk

A new study of a quarter-million Miami-Dade County Medicare beneficiaries showed that higher levels of neighborhood greenness, including trees, grass and other vegetation, were linked to a significant reduction in the rate of chronic illnesses, particularly in low-to-middle income neighborhoods.

22 Apr 2016

Medical Condition News

Study on HDAC enzymes could lead to development of better drugs for treatment of cancer, Alzheimer’s

Newly developed smartphone application may potentially benefit low-vision users

Bupropion, varenicline drugs do not increase risk of serious neuropsychiatric adverse events

Mediterranean diet reduces risk of recurrent heart attacks or strokes

Scientists derive first molecular model of critical transporter at blood-brain barrier

Type 2 diabetes can lead to hearing impairment

Fructose common in western diet can damage brain genes

Study shows cancer cell death via necroptosis can drive pancreatic tumor growth

Why don’t MS patients always engage with specialists? An interview with Dr Anita Rose

Sleep loss influences cholesterol metabolism, study finds

Cancer survivors at risk of death after organ transplant

Under-expressed miR-9 gene may contribute to schizophrenia risk

Long way to go in better understanding brain abnormalities linked with autism

Rituximab drug more effective than fingolimod for patients with highly active multiple sclerosis

3-D imaging of fibroblastic foci may help researchers study disease progression in IPF patients

Unmet nursing care may contribute to racial/ethnic differences in AMI readmissions

Unique mouse model could help study genetic origins and potential treatments for ALS

Rab inhibition may be a promising antimyeloma strategy

Wellderly study finds link between cognitive decline genes and healthy aging

Higher levels of neighborhood greenness linked to lower chronic disease risk

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

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