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Assessing body composition may help predict cardiovascular and total mortality

Researchers from the David Geffen School of Medicine at UCLA found that cardiovascular disease patients who have high muscle mass and low fat mass have a lower mortality risk than those with other body compositions. The findings also suggest that regardless of a person's level of fat mass, a higher level of muscle mass helps reduce the risk of death.

22 Apr 2016

Disorders in PIGG gene can cause intellectual disability with seizures and hypotonia

A research group led by Osaka University and collaborative institutions discovered that disorders in the same gene PIGG are the cause for intellectual disability with seizures and hypotonia. PIGG is one of the enzymes active in the GPI anchor glycolipid synthesis and the current study revealed its significance in the development of the cerebral nervous system.

22 Apr 2016

Study indicates that resolvin D1 has anti-arthritic properties

Rheumatoid arthritis (RA) is a debilitating autoimmune disorder that is characterized by the accumulation of inflammatory cells within the fluid of the joints. Current therapeutic strategies mostly serve to ease pain and rarely are able to reverse damage or resolve inflammation.

22 Apr 2016

Scientists identify critical biological factor for transforming adult somatic cells into stem cells

In a new Cell Reports paper, a team led by John P. Cooke, M.D., Ph.D., of the Houston Methodist Research Institute, has identified and characterized a biological factor critical to the transformation of adult somatic cells (cells that are not sperm or egg cells) into stem cells.

22 Apr 2016

Study finds low prevalence of vascular risk among Southwest US population

In a newly published, pilot study in the journal Ethnicity & Disease, researchers report a relatively low prevalence of vascular risk among participants of the Southwest Heart Mind Study, especially among those treated for hypertension and hyperlipidemia despite overweight and obesity.

22 Apr 2016

Open source machine learning tools as good as humans in detecting cancer cases

Machine learning has come of age in public health reporting according to researchers from the Regenstrief Institute and Indiana University School of Informatics and Computing at Indiana University-Purdue University Indianapolis.

22 Apr 2016

U of M to present session on Canine and Human Epilepsy at iCOMOS

As part of the International Conference on One Medicine One Science taking place April 24-27, the University of Minnesota will present a session on Canine and Human Epilepsy on April 27.

22 Apr 2016

Spatial navigation task used to access cognitive map skills can detect preclinical Alzheimer's disease

Long before Alzheimer's disease can be diagnosed clinically, increasing difficulties building cognitive maps of new surroundings may herald the eventual clinical onset of the disorder, finds new research from Washington University in St. Louis.

22 Apr 2016

CUMC researchers identify new neurodevelopmental syndrome

A multicenter research team led by Columbia University Medical Center has discovered a new neurodevelopmental syndrome and the genetic mutations that cause it. The discovery is an important step toward creating targeted therapies for individuals with this syndrome, which causes severe developmental delays, abnormal muscle tone, seizures, and eye complications.

22 Apr 2016

Scientists identify genetic mechanisms behind development of myopia

Myopia, also known as short-sightedness or near-sightedness, is the most common disorder affecting the eyesight and it is on the increase. The causes are both genetic and environmental.

22 Apr 2016

Microtubules affect mechanics of beating heart, study finds

On top of the meaning and mystery that humans heap on the heart, it is first and foremost, a muscle. And one that beats about once a second for a person's entire life, with no rest. Given its vital importance, it's ironic researchers have only recently made direct observations of its subcellular parts in motion.

22 Apr 2016

GSK3β inhibition may be potential therapeutic strategy for treating ACM

Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disease that results from mutations in genes that encode components of the cardiac desmosome, which forms the junction between cardiac muscle and the epithelium. Patients with ACM have an increased risk of sudden death due to the breakdown of the muscle wall of the heart with age.

22 Apr 2016

PPP3CA, calcineurin may be suitable therapeutic targets for multiple myeloma treatment

Multiple myeloma (MM) is a hematological cancer that frequently acquires resistance to chemotherapeutic drugs. Additionally, many patients experience disease relapse, but these patients are difficult to treat as the cancer is often resistant to the previous treatment regimen.

22 Apr 2016

FAU's clinical trial to evaluate efficacy of RVT-101 tablet for Lewy body dementia

Florida Atlantic University's Charles E. Schmidt College of Medicine is spearheading the South Florida site for the first U.S. clinical trial for Lewy body dementia (LBD), the second-most common dementia after Alzheimer's disease. The HEADWAY-DLB is a phase 2b multi-center, double-blind, placebo-controlled study to evaluate an investigational medicine, RVT-101, for dementia with Lewy bodies.

22 Apr 2016

Study links duration, timing of sleep to cardiovascular health

No one is telling you what time to go to bed with this, but researchers are making a strong case that the duration and timing of your sleep are closely associated with whether your behavior is heart-healthy.

22 Apr 2016

Subtle changes in protein-coding gene may cause different genetic disorders

It has been disorienting to the scientific and medical community as to why different subtle changes in a protein-coding gene causes many different genetic disorders in different patients -- including premature aging, nerve problems, heart problems and muscle problems. no other gene works like this. According to a new study, co-authored by Binghamton University faculty Eric Hoffman, it has to do with cell "commitment."

22 Apr 2016

Scientists examine PD-1-expressing regulatory T cells in aggressive brain cancer

Immunotherapy represents an exciting advance in cancer treatment that harnesses the immune system to seek and destroy cancer cells.

22 Apr 2016

Study paves way for refining antibody-based cancer immunotherapy

A study coordinated by the Malmberg Laboratory at Oslo University Hospital/University of Oslo and the Karolinska Institute, published in Cell Reports, reveals a molecule that trigger cancer recognition in natural killer (NK) cells.

22 Apr 2016

More cautious blood pressure-lowering strategy may be reasonable for elderly CKD patients

New research indicates that higher systolic blood pressure is linked with poor outcomes in patients with kidney disease, although the association diminishes with advanced age. The findings, which come from a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN), provide valuable information concerning patients who are often excluded from blood pressure-lowering clinical trials.

22 Apr 2016

Increasing specialist community services reduces suicide rates in NHS mental health services in England

Increasing specialist community services like crisis resolution, helping make the transition to adult services smoother for young people, and implementing clinical guidelines are just some of the service changes that are linked to significantly reduced suicide rates in mental health services in England over the last 16 years, according to new research published in The Lancet Psychiatry journal.

22 Apr 2016

Medical Condition News

Assessing body composition may help predict cardiovascular and total mortality

Disorders in PIGG gene can cause intellectual disability with seizures and hypotonia

Study indicates that resolvin D1 has anti-arthritic properties

Scientists identify critical biological factor for transforming adult somatic cells into stem cells

Study finds low prevalence of vascular risk among Southwest US population

Open source machine learning tools as good as humans in detecting cancer cases

U of M to present session on Canine and Human Epilepsy at iCOMOS

Spatial navigation task used to access cognitive map skills can detect preclinical Alzheimer's disease

CUMC researchers identify new neurodevelopmental syndrome

Scientists identify genetic mechanisms behind development of myopia

Microtubules affect mechanics of beating heart, study finds

GSK3β inhibition may be potential therapeutic strategy for treating ACM

PPP3CA, calcineurin may be suitable therapeutic targets for multiple myeloma treatment

FAU's clinical trial to evaluate efficacy of RVT-101 tablet for Lewy body dementia

Study links duration, timing of sleep to cardiovascular health

Subtle changes in protein-coding gene may cause different genetic disorders

Scientists examine PD-1-expressing regulatory T cells in aggressive brain cancer

Study paves way for refining antibody-based cancer immunotherapy

More cautious blood pressure-lowering strategy may be reasonable for elderly CKD patients

Increasing specialist community services reduces suicide rates in NHS mental health services in England

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

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